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Journal List > Biochem J > v.155(2); May 1, 1976

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Biochem J. 1976 May 1; 155(2): 445–448.
PMCID: PMC1172852
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The effect of some analogues of disulfiram on the aldehyde dehydrogenases of sheep liver.
T M Kitson
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Abstract
The effect of some close structural analogues of disulfiram on the activity of the cytoplasmic and mitochondrial aldehyde dehydrogenases of sheep liver was studied. Several thiuram disulphides are equally potent inhibitors of the cytoplasmic enzyme, but in all cases the mitochondrial enzyme is much less strongly affected. Tetramethylthiuram monosulphide decreases the activity of the cytoplasmic enzyme in a process apparently involving a covalent interaction.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Crow KE, Kitson TM, MacGibbon AK, Batt RD. Intracellular localisation and properties of aldehyde dehydrogenases from sheep liver. Biochim Biophys Acta. 1974 May 20;350(1):121–128. [PubMed]
  • Deitrich RA. Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. 3. Sulfhydryl characteristics of the enzyme. Arch Biochem Biophys. 1967 Mar;119(1):253–263. [PubMed]
  • Deitrich RA, Erwin VG. Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate. Mol Pharmacol. 1971 May;7(3):301–307. [PubMed]
  • Gessner T, Jakubowski M. Diethyldithiocarbamic acid methyl ester. A metabolite of disulfiram. Biochem Pharmacol. 1972 Jan 15;21(2):219–230. [PubMed]
  • GOLDSTEIN M, ANAGNOSTE B, LAUBER E, MCKEREGHAM MR. INHIBITION OF DOPAMINE-BETA-HYDROXYLASE BY DISULFIRAM. Life Sci. 1964 Jul;3:763–767. [PubMed]
  • HALD J, JACOBSEN E, LARSEN V. The antabuse effect of some compounds related to antabuse and cyanamide. Acta Pharmacol Toxicol (Copenh). 1952;8(4):329–337. [PubMed]
  • Kitson TM. The effect of disulfiram on the aldehyde dehydrogenases of sheep liver. Biochem J. 1975 Nov;151(2):407–412. [PubMed]
  • Neims AH, Coffey DS, Hellerman L. A sensitive radioassay for sulfhydryl groups with tetraethylthiuram disulfide. J Biol Chem. 1966 Jul 10;241(13):3036–3040. [PubMed]
  • Neims AH, Coffey DS, Hellerman L. Interaction between tetraethylthiuram disulfide and the sulfhydryl groups of D-amino acid oxidase and of hemoglobin. J Biol Chem. 1966 Dec 25;241(24):5941–5948. [PubMed]
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