• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of janatLink to Publisher's site
J Anat. Aug 1981; 133(Pt 1): 77–90.
PMCID: PMC1167726

Fibroblast cell proliferation in the mouse molar periodontal ligament.

Abstract

Cytogenesis of the developing molar periodontal ligament was studied by determining labelling indices in 4 groups of young mice. Autoradiographs were made using paraffin sections of demineralised specimens from 10 days, 12 days, 16 days and 20 days old mice allowed to survive a varying period (1--96 hours) after the administration of [3H]thymidine. Labelled fibroblasts in number per unit area were counted over three different zones (apical, middle and cervical) of the sections and labelling index distribution curves were drawn. The present study has demonstrated the existence of a progenitor area with proliferating fibroblasts in the apical zone and a migration of these cells into other zones (middle and cervical). However, it has also shown that a measurable proliferative rate is present at all levels of the molar periodontal ligament in all ages of animals investigated. Such an observation if compatible with fibroblasts migrating from the apical zone in an occlusal direction and maintaining a decreasing degree of proliferative activity as they progress. Consequently, a tentative apico-occlusal migratory model for the periodontal ligament fibroblast proliferation and migration is proposed. Accordingly, fibroblast proliferation takes place in the apical progenitor zone, and cells migrate from the apical zone to middle and cervical zones, but maintaining a decreasing degree of proliferative activity as they migrate. Peak proliferative and migratory activity is seen in the 12 days group which is also the time that tooth eruption takes place in the mouse. Thus, a close relationship exists between fibroblast cell proliferation, migration and tooth eruption.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (3.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Abercrombie M, Heaysman JE, Pegrum SM. The locomotion of fibroblasts in culture. IV. Electron microscopy of the leading lamella. Exp Cell Res. 1971 Aug;67(2):359–367. [PubMed]
  • Beertsen W. Tissue dynamics in the periodontal ligament of the mandibular incisor of the mouse: a preliminary report. Arch Oral Biol. 1973 Jan;18(1):61–66. [PubMed]
  • Beertsen W, Everts V, van den Hooff A. Fine structure of fibroblasts in the periodontal ligament of the rat incisor and their possible role in tooth eruption. Arch Oral Biol. 1974 Dec;19(12):1087–1098. [PubMed]
  • Chiba M. Cellular proliferation in the tooth germ of the rat incisor. Arch Oral Biol. 1965 Jul-Aug;10(4):707–718. [PubMed]
  • Melcher AH. Remodelling of the periodontal ligament during eruption of the rat incisor. Arch Oral Biol. 1967 Dec;12(12):1649–1651. [PubMed]
  • NESS AR. MOVEMENT AND FORCES IN TOOTH ERUPTION. Adv Oral Biol. 1964;1:33–75. [PubMed]
  • Ross R. The fibroblast and wound repair. Biol Rev Camb Philos Soc. 1968 Feb;43(1):51–96. [PubMed]
  • ten Cate AR. Cell division and periodontal ligament formation in the mouse. Arch Oral Biol. 1972 Dec;17(12):1781–1784. [PubMed]
  • Ten Cate AR, Mills C. The development of the periodontium: the origin of alveolar bone. Anat Rec. 1972 May;173(1):69–77. [PubMed]
  • Ten Cate AR, Mills C, Solomon G. The development of the periodontium. A transplantation and autoradiographic study. Anat Rec. 1971 Jul;170(3):365–379. [PubMed]
  • Van Winkle W., Jr The fibroblast in wound healing. Surg Gynecol Obstet. 1967 Feb;124(2):369–386. [PubMed]
  • Van Winkle W., Jr Wound contraction. Surg Gynecol Obstet. 1967 Jul;125(1):131–142. [PubMed]
  • Vasiliev JM, Gelfand IM, Domnina LV, Ivanova OY, Komm SG, Olshevskaja LV. Effect of colcemid on the locomotory behaviour of fibroblasts. J Embryol Exp Morphol. 1970 Nov;24(3):625–640. [PubMed]
  • Zajicek G. Fibroblast cell kinetics in the periodontal ligament of the mouse. Cell Tissue Kinet. 1974 Sep;7(5):479–492. [PubMed]

Articles from Journal of Anatomy are provided here courtesy of Anatomical Society of Great Britain and Ireland

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...