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EMBO J. Feb 1986; 5(2): 409–413.
PMCID: PMC1166746

Location of 'continuous' antigenic determinants in the protruding regions of proteins.


A simple method is described to locate 'antigenic' peptides from the alpha-carbon co-ordinates of a protein, based on protrusion from the protein's globular surface. A good correlation is found between those parts of a protein which protrude and the experimentally determined antigenic peptides in myoglobin, lysozyme and myohemerythrin. A comparison is made between the use of protrusion index, mobility, solvent accessibility and hydrophilicity for predicting the most likely antigenic peptides.

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Selected References

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