Logo of biochemjBJ Latest papers and much more!
Biochem J. 1977 Feb 15; 162(2): 405–410.
PMCID: PMC1164614

Surface components involved in virally mediated membrane changes.


1. Virally mediated permeability changes are not brought about by neuraminidase or other enzyme. They are not mimicked by local anaesthetics such as benzyl alcohol or dibucaine. 2. Virus induces an increase in the exchange rate of membrane-bound Ca2+. The temperature-dependence, and sensitivity to concanavalin A, of the permeability change and of Ca2+ exchange are similar. 3. It is concluded that an increase in the exchangeability of membrane-bound Ca2+ constitutes an early and specific event after the attachment of Sendai virus to cultured cells.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (917K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Borle AB. Calcium metabolism at the cellular level. Fed Proc. 1973 Sep;32(9):1944–1950. [PubMed]
  • DULBECCO R, VOGT M. Plaque formation and isolation of pure lines with poliomyelitis viruses. J Exp Med. 1954 Feb;99(2):167–182. [PMC free article] [PubMed]
  • Elsbach P, Holmes KV, Choppin PW. Metabolism of lecithin and virus-induced cell fusion. Proc Soc Exp Biol Med. 1969 Mar;130(3):903–908. [PubMed]
  • Falke D, Schiefer HG, Stoffel W. Lipoid-Analysen bei Riesenzellbildung durch Herpesvirus Hominis. Z Naturforsch B. 1967 Dec;22(12):1360–1362. [PubMed]
  • Freedman MH, Raff MC. Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotides. Nature. 1975 May 29;255(5507):378–382. [PubMed]
  • GREEN H, BARROW P, GOLDBERG B. Effect of antibody and complement on permeability control in ascites tumor cells and erythrocytes. J Exp Med. 1959 Nov 1;110:699–713. [PMC free article] [PubMed]
  • Holmes KV, Klenk HD, Choppin PW. A comparison of immune cytolysis and virus-induced fusion of sensitive and resistant cell types. Proc Soc Exp Biol Med. 1969 Jun;131(2):651–657. [PubMed]
  • Homma M, Shimizu K, Shimizu YK, Ishida N. On the study of Sendai virus hemolysis. I. Complete Sendai virus lacking in hemolytic activity. Virology. 1976 May;71(1):41–47. [PubMed]
  • KLEMPERER HG. An effect of phloridzin on influenza virus elution and on neuraminidase activity. Virology. 1960 Nov;12:495–498. [PubMed]
  • KLEMPERER HG. Hemolysis and the release of potassium from cells by Newcastle disease virus (NDV). Virology. 1960 Dec;12:540–552. [PubMed]
  • Müller-Eberhard HJ. Complement. Annu Rev Biochem. 1975;44:697–724. [PubMed]
  • Papahadjopoulos D. Studies on the mechanism of action of local anesthetics with phospholipid model membranes. Biochim Biophys Acta. 1972 Apr 18;265(2):169–186. [PubMed]
  • Pasternak CA, Micklem KJ. Permeability changes during cell fusion. J Membr Biol. 1973;14(3):293–303. [PubMed]
  • Pasternak CA, Micklem KJ. The biochemistry of virus-induced cell fusion. Changes in membrane integrity. Biochem J. 1974 Jun;140(3):405–411. [PMC free article] [PubMed]
  • Pasternak CA, Micklem KJ. Virally mediated membrane changes: inverse effects on transport and diffusion. Biochem J. 1974 Dec;144(3):593–595. [PMC free article] [PubMed]
  • Poste G, Allison AC. Membrane fusion. Biochim Biophys Acta. 1973 Dec 28;300(4):421–465. [PubMed]
  • Rasmussen H. Cell communication, calcium ion, and cyclic adenosine monophosphate. Science. 1970 Oct 23;170(3956):404–412. [PubMed]
  • Rose B, Loewenstein WR. Permeability of cell junction depends on local cytoplasmic calcium activity. Nature. 1975 Mar 20;254(5497):250–252. [PubMed]
  • Seeman P. The membrane actions of anesthetics and tranquilizers. Pharmacol Rev. 1972 Dec;24(4):583–655. [PubMed]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...