• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of janatLink to Publisher's site
J Anat. May 1984; 138(Pt 3): 537–552.
PMCID: PMC1164337

Histogenesis of the mesocortical area of the mouse telencephalon.

Abstract

The histogenesis of the mesocortex of the mouse telencephalon was studied by plotting the progress of neuron release on reconstructions of the medial pallial wall. Histological changes were correlated with cell birth date using data obtained from autoradiographs of mice pulse-labelled with tritiated thymidine during the prenatal period of neuron birth. It was found that neuron release for this area began rostrally at about E12-E13 and spread rapidly from this origin in a caudal direction across the medial wall. Neurons accumulating in the intermediate layer were at first more or less equally spaced. About E14, neurons in the outer intermediate layer began to line up to form a 'mesocortical plate'. This plate was formed from older nuclei and therefore overlay a deeper intermediate layer composed of younger cells. The mesocortex continued to develop by progressive withdrawal of younger cells from the deep intermediate layer into more superficial layers of the definitive cortex. In most of the mesocortical area, however, this original pattern was superseded by release of neuron generations which migrated directly to the outer intermediate layer to form a plate of densely packed immature neurons. This population was continuous with a similar population forming the isocortical plate of the lateral telencephalic wall. It was postulated that the wave of neuron birth and release which gave rise to the isocortical plate was propagated beyond the isocortical boundary into mesocortical territory as far as the boundaries of the subiculum, indusium griseum and anterior hippocampal rudiment.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (4.8M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Caviness VS., Jr Architectonic map of neocortex of the normal mouse. J Comp Neurol. 1975 Nov 15;164(2):247–263. [PubMed]
  • Marin-Padilla M. Early prenatal ontogenesis of the cerebral cortex (neocortex) of the cat (Felis domestica). A Golgi study. I. The primordial neocortical organization. Z Anat Entwicklungsgesch. 1971;134(2):117–145. [PubMed]
  • Marin-Padilla M. Dual origin of the mammalian neocortex and evolution of the cortical plate. Anat Embryol (Berl) 1978 Feb 20;152(2):109–126. [PubMed]
  • Rickmann M, Chronwall BM, Wolff JR. On the development of non-pyramidal neurons and axons outside the cortical plate: the early marginal zone as a pallial anlage. Anat Embryol (Berl) 1977 Dec 2;151(3):285–307. [PubMed]
  • Smart IH. Proliferative characteristics of the ependymal layer during the early development of the mouse neocortex: a pilot study based on recording the number, location and plane of cleavage of mitotic figures. J Anat. 1973 Oct;116(Pt 1):67–91. [PMC free article] [PubMed]
  • Smart IH. Radial unit analysis of hippocampal histogenesis in the mouse. J Anat. 1982 Dec;135(Pt 4):763–793. [PMC free article] [PubMed]
  • Smart IH. Three dimensional growth of the mouse isocortex. J Anat. 1983 Dec;137(Pt 4):683–694. [PMC free article] [PubMed]
  • Smart IH, Smart M. Growth patterns in the lateral wall of the mouse telencephalon: I. Autoradiographic studies of the histogenesis of the isocortex and adjacent areas. J Anat. 1982 Mar;134(Pt 2):273–298. [PMC free article] [PubMed]

Articles from Journal of Anatomy are provided here courtesy of Anatomical Society of Great Britain and Ireland

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...