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J Physiol. Jan 15, 1997; 498(Pt 2): 553–559.
PMCID: PMC1159224

Role of caloric content on gastric emptying in humans.


1. This study examined the effects of caloric content (caloric density and the nature of calories) on the rate of gastric emptying using the double-sampling gastric aspiration technique. Four test meals of 600 ml (glucose, 0.1 kcal ml-1; pea and whey peptide hydrolysates, both 0.2 kcal ml-1; milk protein, 0.7 kcal ml-1) were tested in six healthy subjects in random order on four separate occasions. 2. The glucose solution was emptied the fastest with a half-time of 9.4 +/- 1.2 min (P < 0.05) and the milk protein the slowest with a half-time of 26.4 +/- 10.0 min (P < 0.05); the pea peptide hydrolysate and whey peptide hydrolysate solutions had half-times of emptying of 16.3 +/- 5.4 and 17.2 +/- 6.1 min, respectively. The rates of gastric emptying for the peptide hydrolysate solutions derived from different protein sources were not different. 3. Despite the lower rate of gastric emptying for the milk protein solution, the rate of caloric delivery to the duodenum during the early phase of the gastric emptying process was higher than that for the other three solutions (46.3 +/- 6, 63.5 +/- 22, 62.5 +/- 19 and 113.8 +/- 25 cal min-1 kg-1 for the glucose, pea peptide hydrolysate, whey peptide hydrolysate and milk protein meals, respectively; P < 0.05). The caloric density of the test solutions was linearly related to the half-time of gastric emptying (r = 0.96, P < 0.05) as well as to the rate at which calories were delivered to the duodenum (r = 0.99, P < 0.001). 4. This study demonstrates that the rate of gastric emptying is a function of the caloric density of the ingested meal and that a linear relationship exists between these variables. Furthermore, the nature of the calories seems to play a minor role in determining the rate of gastric emptying in humans.

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Selected References

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  • Baglieri A, Mahe S, Zidi S, Huneau JF, Thuillier F, Marteau P, Tome D. Gastro-jejunal digestion of soya-bean-milk protein in humans. Br J Nutr. 1994 Oct;72(4):519–532. [PubMed]
  • Beckers EJ, Leiper JB, Davidson J. Comparison of aspiration and scintigraphic techniques for the measurement of gastric emptying rates of liquids in humans. Gut. 1992 Jan;33(1):115–117. [PMC free article] [PubMed]
  • Beckers EJ, Rehrer NJ, Brouns F, Ten Hoor F, Saris WH. Determination of total gastric volume, gastric secretion and residual meal using the double sampling technique of George. Gut. 1988 Dec;29(12):1725–1729. [PMC free article] [PubMed]
  • Brener W, Hendrix TR, McHugh PR. Regulation of the gastric emptying of glucose. Gastroenterology. 1983 Jul;85(1):76–82. [PubMed]
  • Costill DL, Saltin B. Factors limiting gastric emptying during rest and exercise. J Appl Physiol. 1974 Nov;37(5):679–683. [PubMed]
  • Curran PF, Schultz SG, Chez RA, Fuisz RE. Kinetic relations of the Na-amino acid interaction at the mucosal border of intestine. J Gen Physiol. 1967 May;50(5):1261–1286. [PMC free article] [PubMed]
  • Cunha Ferreira RM, Elliott EJ, Watson AJ, Brennan E, Walker-Smith JA, Farthing MJ. Dominant role for osmolality in the efficacy of glucose and glycine-containing oral rehydration solutions: studies in a rat model of secretory diarrhoea. Acta Paediatr. 1992 Jan;81(1):46–50. [PubMed]
  • Fisher RS, Rock E, Malmud LS. Effects of meal composition on gallbladder and gastric emptying in man. Dig Dis Sci. 1987 Dec;32(12):1337–1344. [PubMed]
  • Holt S, Heading RC, Carter DC, Prescott LF, Tothill P. Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet. 1979 Mar 24;1(8117):636–639. [PubMed]
  • Hunt JB, Thillainayagam AV, Salim AF, Carnaby S, Elliott EJ, Farthing MJ. Water and solute absorption from a new hypotonic oral rehydration solution: evaluation in human and animal perfusion models. Gut. 1992 Dec;33(12):1652–1659. [PMC free article] [PubMed]
  • HUNT JN, MACDONALD I. The influence of volume on gastric emptying. J Physiol. 1954 Dec 10;126(3):459–474. [PMC free article] [PubMed]
  • Hunt JN, Smith JL, Jiang CL. Effect of meal volume and energy density on the gastric emptying of carbohydrates. Gastroenterology. 1985 Dec;89(6):1326–1330. [PubMed]
  • Hunt JN, Stubbs DF. The volume and energy content of meals as determinants of gastric emptying. J Physiol. 1975 Feb;245(1):209–225. [PMC free article] [PubMed]
  • Lin HC, Doty JE, Reedy TJ, Meyer JH. Inhibition of gastric emptying by acids depends on pH, titratable acidity, and length of intestine exposed to acid. Am J Physiol. 1990 Dec;259(6 Pt 1):G1025–G1030. [PubMed]
  • Lin HC, Doty JE, Reedy TJ, Meyer JH. Inhibition of gastric emptying by sodium oleate depends on length of intestine exposed to nutrient. Am J Physiol. 1990 Dec;259(6 Pt 1):G1031–G1036. [PubMed]
  • Lin HC, Elashoff JD, Gu YG, Meyer JH. Nutrient feedback inhibition of gastric emptying plays a larger role than osmotically dependent duodenal resistance. Am J Physiol. 1993 Oct;265(4 Pt 1):G672–G676. [PubMed]
  • Mahé S, Huneau JF, Marteau P, Thuillier F, Tomé D. Gastroileal nitrogen and electrolyte movements after bovine milk ingestion in humans. Am J Clin Nutr. 1992 Aug;56(2):410–416. [PubMed]
  • Mitchell JB, Voss KW. The influence of volume on gastric emptying and fluid balance during prolonged exercise. Med Sci Sports Exerc. 1991 Mar;23(3):314–319. [PubMed]
  • Rehrer NJ, Beckers E, Brouns F, Hoor ten F, Saris WH. Exercise and training effects on gastric emptying of carbohydrate beverages. Med Sci Sports Exerc. 1989 Oct;21(5):540–549. [PubMed]
  • Sidery MB, Macdonald IA, Blackshaw PE. Superior mesenteric artery blood flow and gastric emptying in humans and the differential effects of high fat and high carbohydrate meals. Gut. 1994 Feb;35(2):186–190. [PMC free article] [PubMed]
  • Velchik MG, Reynolds JC, Alavi A. The effect of meal energy content on gastric emptying. J Nucl Med. 1989 Jun;30(6):1106–1110. [PubMed]
  • Vist GE, Maughan RJ. Gastric emptying of ingested solutions in man: effect of beverage glucose concentration. Med Sci Sports Exerc. 1994 Oct;26(10):1269–1273. [PubMed]
  • Vist GE, Maughan RJ. The effect of osmolality and carbohydrate content on the rate of gastric emptying of liquids in man. J Physiol. 1995 Jul 15;486(Pt 2):523–531. [PMC free article] [PubMed]

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