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Logo of jphysiolThe Journal of Physiology SiteMembershipSubmissionJ Physiol
J Physiol. Feb 1, 1997; 498(Pt 3): 817–823.
PMCID: PMC1159197

Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans.

Abstract

1. Changes in excitability of the motor cortex induced by a transcranial magnetic stimulation (TMS) were examined by simultaneous recording of the evoked corticospinal volley and the compound surface electromyographic (EMG) response in the biceps brachii following paired-pulse TMS in five conscious subjects. The effects of a varying interstimulus interval (ISI) and a conditioning stimulus intensity were also investigated. 2. A submotor threshold conditioning stimulus inhibited the test responses at ISIs of 2-5 ms. A supramotor threshold conditioning stimulus inhibited the test responses at ISIs of 100-200 ms. Both of these inhibitions were prominent in late I waves. 3. There was a facilitation of the test responses at an ISI of 25 ms that was prominent in late I waves. The facilitation evoked by the supramotor threshold conditioning stimulus was more prominent than that evoked by the submotor threshold conditioning stimulus. 4. It is concluded that single TMS induced the triphasic changes of the motor cortex excitability in conscious humans that resulted in changes in EMG responses following paired TMS.

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Selected References

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  • Amassian VE, Stewart M, Quirk GJ, Rosenthal JL. Physiological basis of motor effects of a transient stimulus to cerebral cortex. Neurosurgery. 1987 Jan;20(1):74–93. [PubMed]
  • Benardo LS. Separate activation of fast and slow inhibitory postsynaptic potentials in rat neocortex in vitro. J Physiol. 1994 Apr 15;476(2):203–215. [PMC free article] [PubMed]
  • Burke D, Hicks RG, Stephen JP. Corticospinal volleys evoked by anodal and cathodal stimulation of the human motor cortex. J Physiol. 1990 Jun;425:283–299. [PMC free article] [PubMed]
  • Clark KA, Randall AD, Collingridge GL. A comparison of paired-pulsed facilitation of AMPA and NMDA receptor-mediated excitatory postsynaptic currents in the hippocampus. Exp Brain Res. 1994;101(2):272–278. [PubMed]
  • Edmonds B, Gibb AJ, Colquhoun D. Mechanisms of activation of glutamate receptors and the time course of excitatory synaptic currents. Annu Rev Physiol. 1995;57:495–519. [PubMed]
  • Fleidervish IA, Gutnick MJ. Paired-pulse facilitation of IPSCs in slices of immature and mature mouse somatosensory neocortex. J Neurophysiol. 1995 Jun;73(6):2591–2595. [PubMed]
  • Fuhr P, Agostino R, Hallett M. Spinal motor neuron excitability during the silent period after cortical stimulation. Electroencephalogr Clin Neurophysiol. 1991 Aug;81(4):257–262. [PubMed]
  • Inghilleri M, Berardelli A, Cruccu G, Manfredi M. Silent period evoked by transcranial stimulation of the human cortex and cervicomedullary junction. J Physiol. 1993 Jul;466:521–534. [PMC free article] [PubMed]
  • Jankowska E, Padel Y, Tanaka R. The mode of activation of pyramidal tract cells by intracortical stimuli. J Physiol. 1975 Aug;249(3):617–636. [PMC free article] [PubMed]
  • Kang Y, Kaneko T, Ohishi H, Endo K, Araki T. Spatiotemporally differential inhibition of pyramidal cells in the cat motor cortex. J Neurophysiol. 1994 Jan;71(1):280–293. [PubMed]
  • Kitagawa H, Nakamura H, Kawaguchi Y, Tsuji H, Satone T, Takano H, Nakatoh S. Magnetic-evoked compound muscle action potential neuromonitoring in spine surgery. Spine (Phila Pa 1976) 1995 Oct 15;20(20):2233–2239. [PubMed]
  • Kujirai T, Caramia MD, Rothwell JC, Day BL, Thompson PD, Ferbert A, Wroe S, Asselman P, Marsden CD. Corticocortical inhibition in human motor cortex. J Physiol. 1993 Nov;471:501–519. [PMC free article] [PubMed]
  • Mody I, De Koninck Y, Otis TS, Soltesz I. Bridging the cleft at GABA synapses in the brain. Trends Neurosci. 1994 Dec;17(12):517–525. [PubMed]
  • Nakamura H, Kitagawa H, Kawaguchi Y, Tsuji H. Direct and indirect activation of human corticospinal neurons by transcranial magnetic and electrical stimulation. Neurosci Lett. 1996 May 24;210(1):45–48. [PubMed]
  • Nakamura H, Kitagawa H, Kawaguchi Y, Tsuji H, Takano H, Nakatoh S. Intracortical facilitation and inhibition after paired magnetic stimulation in humans under anesthesia. Neurosci Lett. 1995 Oct 20;199(2):155–157. [PubMed]
  • PATTON HD, AMASSIAN VE. Single and multiple-unit analysis of cortical stage of pyramidal tract activation. J Neurophysiol. 1954 Jul;17(4):345–363. [PubMed]
  • Pearce RA, Grunder SD, Faucher LD. Different mechanisms for use-dependent depression of two GABAA-mediated IPSCs in rat hippocampus. J Physiol. 1995 Apr 15;484(Pt 2):425–435. [PMC free article] [PubMed]
  • Rothwell JC, Thompson PD, Day BL, Boyd S, Marsden CD. Stimulation of the human motor cortex through the scalp. Exp Physiol. 1991 Mar;76(2):159–200. [PubMed]
  • Valls-Solé J, Pascual-Leone A, Wassermann EM, Hallett M. Human motor evoked responses to paired transcranial magnetic stimuli. Electroencephalogr Clin Neurophysiol. 1992 Dec;85(6):355–364. [PubMed]
  • Yamamoto N, Takano H, Kitagawa H, Kawaguchi Y, Tsuji H, Uozaki Y. Monitoring for spinal cord ischemia by use of the evoked spinal cord potentials during aortic aneurysm surgery. J Vasc Surg. 1994 Nov;20(5):826–833. [PubMed]
  • Keller A. Intrinsic synaptic organization of the motor cortex. Cereb Cortex. 1993 Sep-Oct;3(5):430–441. [PubMed]

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