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Biochem J. Jun 1, 1991; 276(Pt 2): 273–287.
PMCID: PMC1151088

The Ah receptor and the mechanism of dioxin toxicity.

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Selected References

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  • Antakly T, Eisen HJ. Immunocytochemical localization of glucocorticoid receptor in target cells. Endocrinology. 1984 Nov;115(5):1984–1989. [PubMed]
  • Astroff B, Zacharewski T, Safe S, Arlotto MP, Parkinson A, Thomas P, Levin W. 6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities. Mol Pharmacol. 1988 Feb;33(2):231–236. [PubMed]
  • Baars AJ, Jansen M, Breimer DD. The influence of phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on glutathione S-transferase activity of rat liver cytosol. Biochem Pharmacol. 1978;27(21):2487–2497. [PubMed]
  • Bailly A, Atger M, Atger P, Cerbon MA, Alizon M, Vu Haï MT, Logeat F, Milgrom E. The rabbit uteroglobin gene. Structure and interaction with the progesterone receptor. J Biol Chem. 1983 Sep 10;258(17):10384–10389. [PubMed]
  • Bandiera S, Sawyer TW, Campbell MA, Fujita T, Safe S. Competitive binding to the cytosolic 2,3,7,8-tetrachlorodibenzo-p-dioxin receptor. Effects of structure on the affinities of substituted halogenated biphenyls--a QSAR analysis. Biochem Pharmacol. 1983 Dec 15;32(24):3803–3813. [PubMed]
  • Bandiera S, Sawyer T, Romkes M, Zmudzka B, Safe L, Mason G, Keys B, Safe S. Polychlorinated dibenzofurans (PCDFs): effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity. Toxicology. 1984 Aug;32(2):131–144. [PubMed]
  • Bannister R, Biegel L, Davis D, Astroff B, Safe S. 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice. Toxicology. 1989 Feb;54(2):139–150. [PubMed]
  • Beato M. Gene regulation by steroid hormones. Cell. 1989 Feb 10;56(3):335–344. [PubMed]
  • Beatty P, Neal RA. Induction of DT-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (ICDD). Biochem Biophys Res Commun. 1976 Jan 12;68(1):197–204. [PubMed]
  • Beck JS, Goren HJ. Simulation of association curves and 'Scatchard' plots of binding reactions where ligand and receptor are degraded or internalized. J Recept Res. 1983;3(5):561–577. [PubMed]
  • Biegel L, Harris M, Davis D, Rosengren R, Safe L, Safe S. 2,2',4,4',5,5'-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice. Toxicol Appl Pharmacol. 1989 Mar 1;97(3):561–571. [PubMed]
  • Birnbaum LS, Weber H, Harris MW, Lamb JC, 4th, McKinney JD. Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin: increased incidence of cleft palate in mice. Toxicol Appl Pharmacol. 1985 Feb;77(2):292–302. [PubMed]
  • Bombick DW, Madhukar BV, Brewster DW, Matsumura F. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) causes increases in protein kinases particularly protein kinase C in the hepatic plasma membrane of the rat and the guinea pig. Biochem Biophys Res Commun. 1985 Feb 28;127(1):296–302. [PubMed]
  • Boyd-Leinen PA, Fournier D, Spelsberg TC. Nonfunctioning progesterone receptors in the developed oviducts from estrogen-withdrawn immature chicks and in aged nonlaying hens. Endocrinology. 1982 Jul;111(1):30–36. [PubMed]
  • Bradfield CA, Kende AS, Poland A. Kinetic and equilibrium studies of Ah receptor-ligand binding: use of [125I]2-iodo-7,8-dibromodibenzo-p-dioxin. Mol Pharmacol. 1988 Aug;34(2):229–237. [PubMed]
  • Brewster DW, Matsumura F. TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) reduces lipoprotein lipase activity in the adipose tissue of the guinea pig. Biochem Biophys Res Commun. 1984 Jul 31;122(2):810–817. [PubMed]
  • Brewster DW, Madhukar BV, Matsumura F. Influence of 2,3,7,8-TCDD on the protein composition of the plasma membrane of hepatic cells from the rat. Biochem Biophys Res Commun. 1982 Jul 16;107(1):68–74. [PubMed]
  • Bunce NJ, Landers JP, Safe SH. Kinetic models for association of 2,3,7,8-tetrachlorodibenzo-p-dioxin with the Ah receptor. Arch Biochem Biophys. 1988 Nov 15;267(1):384–397. [PubMed]
  • Byard JL. The toxicological significance of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds in human adipose tissue. J Toxicol Environ Health. 1987;22(4):381–403. [PubMed]
  • Carlstedt-Duke JM. Tissue distribution of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Cancer Res. 1979 Aug;39(8):3172–3176. [PubMed]
  • Carson-Jurica MA, Schrader WT, O'Malley BW. Steroid receptor family: structure and functions. Endocr Rev. 1990 May;11(2):201–220. [PubMed]
  • Cato AC, Miksicek R, Schütz G, Arnemann J, Beato M. The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction. EMBO J. 1986 Sep;5(9):2237–2240. [PMC free article] [PubMed]
  • Chen TL, Cone CM, Morey-Holton E, Feldman D. 1 alpha,25-dihydroxyvitamin D3 receptors in cultured rat osteoblast-like cells. Glucocorticoid treatment increases receptor content. J Biol Chem. 1983 Apr 10;258(7):4350–4355. [PubMed]
  • Collins TF, Williams CH. Teratogenic studies with 2,4,5-T and 2,4-D in the hamster. Bull Environ Contam Toxicol. 1971 Nov-Dec;6(6):559–567. [PubMed]
  • Colton T. Herbicide exposure and cancer. JAMA. 1986 Sep 5;256(9):1176–1178. [PubMed]
  • Compton JG, Schrader WT, O'Malley BW. Selective binding of chicken progesterone receptor A subunit to a DNA fragment containing ovalbumin gene sequences. Biochem Biophys Res Commun. 1982 Mar 15;105(1):96–104. [PubMed]
  • Cook JC, Hodgson E. Cytochrome P-450 induction by 3-methylcholanthrene and its antagonism by 2,2-dimethyl-5-t-butyl-1,3-benzodioxole. Biochem Pharmacol. 1986 Jan 15;35(2):167–176. [PubMed]
  • Cook JC, Greenlee WF. Characterization of a specific binding protein for 2,3,7,8-tetrachlorodibenzo-p-dioxin in human thymic epithelial cells. Mol Pharmacol. 1989 May;35(5):713–719. [PubMed]
  • Cook JC, Dold KM, Greenlee WF. An in vitro model for studying the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to human thymus. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):256–268. [PubMed]
  • Cordingley MG, Riegel AT, Hager GL. Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo. Cell. 1987 Jan 30;48(2):261–270. [PubMed]
  • Courtney KD, Moore JA. Teratology studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1971 Nov;20(3):396–403. [PubMed]
  • Courtney KD, Gaylor DW, Hogan MD, Falk HL, Bates RR, Mitchell I. Teratogenic evaluation of 2,4,5-T. Science. 1970 May 15;168(3933):864–866. [PubMed]
  • Dean DC, Knoll BJ, Riser ME, O'Malley BW. A 5'-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene. Nature. 1983 Oct 6;305(5934):551–554. [PubMed]
  • Denis M, Wikström AC, Gustafsson JA. The molybdate-stabilized nonactivated glucocorticoid receptor contains a dimer of Mr 90,000 non-hormone-binding protein. J Biol Chem. 1987 Aug 25;262(24):11803–11806. [PubMed]
  • Denis M, Cuthill S, Wikström AC, Poellinger L, Gustafsson JA. Association of the dioxin receptor with the Mr 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor. Biochem Biophys Res Commun. 1988 Sep 15;155(2):801–807. [PubMed]
  • Denison MS, Vella LM. The hepatic Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: species differences in subunit dissociation. Arch Biochem Biophys. 1990 Mar;277(2):382–388. [PubMed]
  • Denison MS, Harper PA, Okey AB. Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Codistribution of unoccupied receptor with cytosolic marker enzymes during fractionation of mouse liver, rat liver and cultured Hepa-1c1 cells. Eur J Biochem. 1986 Mar 3;155(2):223–229. [PubMed]
  • Denison MS, Vella LM, Okey AB. Structure and function of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Species difference in molecular properties of the receptors from mouse and rat hepatic cytosols. J Biol Chem. 1986 Mar 25;261(9):3987–3995. [PubMed]
  • Denison MS, Vella LM, Okey AB. Structure and function of the Ah receptor: sulfhydryl groups required for binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to cytosolic receptor from rodent livers. Arch Biochem Biophys. 1987 Feb 1;252(2):388–395. [PubMed]
  • Denison MS, Fisher JM, Whitlock JP., Jr The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis. J Biol Chem. 1988 Nov 25;263(33):17221–17224. [PubMed]
  • Denison MS, Fisher JM, Whitlock JP., Jr Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex. J Biol Chem. 1989 Oct 5;264(28):16478–16482. [PubMed]
  • Denison MS, Vella LM, Okey AB. Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver: lack of sensitivity to alkaline phosphatase when compared with that of glucocorticoid receptor. Arch Biochem Biophys. 1989 Sep;273(2):458–465. [PubMed]
  • Denomme MA, Leece B, Li A, Towner R, Safe S. Elevation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) polychlorinated biphenyls. Structure-activity relationships. Biochem Pharmacol. 1986 Jan 15;35(2):277–282. [PubMed]
  • Diamond MI, Miner JN, Yoshinaga SK, Yamamoto KR. Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science. 1990 Sep 14;249(4974):1266–1272. [PubMed]
  • Dubik D, Dembinski TC, Shiu RP. Stimulation of c-myc oncogene expression associated with estrogen-induced proliferation of human breast cancer cells. Cancer Res. 1987 Dec 15;47(24 Pt 1):6517–6521. [PubMed]
  • Elferink CJ, Whitlock JP., Jr 2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible, Ah receptor-mediated bending of enhancer DNA. J Biol Chem. 1990 Apr 5;265(10):5718–5721. [PubMed]
  • Elferink CJ, Gasiewicz TA, Whitlock JP., Jr Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric. J Biol Chem. 1990 Nov 25;265(33):20708–20712. [PubMed]
  • Evans RM. The steroid and thyroid hormone receptor superfamily. Science. 1988 May 13;240(4854):889–895. [PubMed]
  • Fingerhut MA, Halperin WE, Marlow DA, Piacitelli LA, Honchar PA, Sweeney MH, Greife AL, Dill PA, Steenland K, Suruda AJ. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. N Engl J Med. 1991 Jan 24;324(4):212–218. [PubMed]
  • Fink KL, Wieben ED, Woloschak GE, Spelsberg TC. Rapid regulation of c-myc protooncogene expression by progesterone in the avian oviduct. Proc Natl Acad Sci U S A. 1988 Mar;85(6):1796–1800. [PMC free article] [PubMed]
  • Flick DF, Firestone D, Ress J, Allen JR. Studies of the chick edema disease. 10. Toxicity of chick edema factors in the chick, chick embryo, and monkey. Poult Sci. 1973 Jul;52(4):1637–1641. [PubMed]
  • Forman BM, Samuels HH. Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model. Mol Endocrinol. 1990 Sep;4(9):1293–1301. [PubMed]
  • Fujisawa-Sehara A, Sogawa K, Nishi C, Fujii-Kuriyama Y. Regulatory DNA elements localized remotely upstream from the drug-metabolizing cytochrome P-450c gene. Nucleic Acids Res. 1986 Feb 11;14(3):1465–1477. [PMC free article] [PubMed]
  • Gallo MA, Hesse EJ, Macdonald GJ, Umbreit TH. Interactive effects of estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic cytochrome P-450 and mouse uterus. Toxicol Lett. 1986 Jul-Aug;32(1-2):123–132. [PubMed]
  • Gasiewicz TA, Bauman PA. Heterogeneity of the rat hepatic Ah receptor and evidence for transformation in vitro and in vivo. J Biol Chem. 1987 Feb 15;262(5):2116–2120. [PubMed]
  • Gasiewicz TA, Neal RA. 2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs. Toxicol Appl Pharmacol. 1979 Nov;51(2):329–339. [PubMed]
  • Gasiewicz TA, Neal RA. The examination and quantitation of tissue cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using hydroxylapatite. Anal Biochem. 1982 Jul 15;124(1):1–11. [PubMed]
  • Gasiewicz TA, Rucci G. Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species. Mol Pharmacol. 1984 Jul;26(1):90–98. [PubMed]
  • Gaub MP, Bellard M, Scheuer I, Chambon P, Sassone-Corsi P. Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex. Cell. 1990 Dec 21;63(6):1267–1276. [PubMed]
  • Gehring U, Tomkins GM. A new mechanism for steroid unresponsiveness: loss of nuclear binding activity of a steroid hormone receptor. Cell. 1974 Nov;3(3):301–306. [PubMed]
  • Gierthy JF, Crane D. Reversible inhibition of in vitro epithelial cell proliferation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1984 Jun 15;74(1):91–98. [PubMed]
  • Gillner M, Bergman J, Cambillau C, Fernström B, Gustafsson JA. Interactions of indoles with specific binding sites for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Mol Pharmacol. 1985 Oct;28(4):357–363. [PubMed]
  • Gillner M, Haldosén LA, Gustafsson SA, Gustafsson JA. Detection of specific binding of [1,6-3H]2,3,7,8-tetrachlordibenzo-p- dioxin ([3H]TCDD) in human leukocytes using electrofocusing in polyacrylamide gel. Toxicol Lett. 1989 Apr;47(1):41–51. [PubMed]
  • Golas CL, Prokipcak RD, Okey AB, Manchester DK, Safe S, Fujita T. Competitive binding of 7-substituted-2,3-dichlorodibenzo-p-dioxins with human placental ah receptor--a QSAR analysis. Biochem Pharmacol. 1990 Aug 15;40(4):737–741. [PubMed]
  • Goldberger A, Spelsberg TC. Partial purification and preparation of polyclonal antibodies against candidate chromatin acceptor proteins for the avian oviduct progesterone receptor. Biochemistry. 1988 Mar 22;27(6):2103–2109. [PubMed]
  • Goldberger A, Littlefield BA, Katzmann J, Spelsberg TC. Monoclonal antibodies recognizing the nuclear binding sites of the avian oviduct progesterone receptor. Endocrinology. 1986 Jun;118(6):2235–2241. [PubMed]
  • Goldberger A, Horton M, Katzmann J, Spelsberg TC. Characterization of the chromatin acceptor sites for the avian oviduct progesterone receptor using monoclonal antibodies. Biochemistry. 1987 Sep 8;26(18):5811–5816. [PubMed]
  • Gonzalez FJ, Nebert DW. Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P1(450) gene. Nucleic Acids Res. 1985 Oct 25;13(20):7269–7288. [PMC free article] [PubMed]
  • Gorski J, Toft D, Shyamala G, Smith D, Notides A. Hormone receptors: studies on the interaction of estrogen with the uterus. Recent Prog Horm Res. 1968;24:45–80. [PubMed]
  • Greig JB. Effect of 2,3,7,8-tetrachlorodibenzo-1,4-dioxin on drug metabolism in the rat. Biochem Pharmacol. 1972 Dec 1;21(23):3196–3198. [PubMed]
  • Greig JB, De Matteis F. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice. Environ Health Perspect. 1973 Sep;5:211–219. [PMC free article] [PubMed]
  • Gruol DJ, Wolfe KA. Transformed glucocorticoid receptors consist of multiple subspecies with differing capacities to bind DNA-cellulose. Biochemistry. 1989 Apr 4;28(7):2929–2936. [PubMed]
  • Gudas JM, Hankinson O. Reversible inactivation of the Ah receptor associated with changes in intracellular ATP levels. J Cell Physiol. 1986 Sep;128(3):449–456. [PubMed]
  • Gudas JM, Karenlampi SO, Hankinson O. Intracellular location of the Ah receptor. J Cell Physiol. 1986 Sep;128(3):441–448. [PubMed]
  • Gustafsson JA, Carlstedt-Duke J, Poellinger L, Okret S, Wikström AC, Brönnegård M, Gillner M, Dong Y, Fuxe K, Cintra A. Biochemistry, molecular biology, and physiology of the glucocorticoid receptor. Endocr Rev. 1987 May;8(2):185–234. [PubMed]
  • Haake JM, Safe S, Mayura K, Phillips TD. Aroclor 1254 as an antagonist of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Lett. 1987 Oct;38(3):299–306. [PubMed]
  • Hankinson O, Andersen RD, Birren BW, Sander F, Negishi M, Nebert DW. Mutations affecting the regulation of transcription of the cytochrome P1-450 gene in the mouse Hepa-1 cell line. J Biol Chem. 1985 Feb 10;260(3):1790–1795. [PubMed]
  • Hannah RR, Lund J, Poellinger L, Gillner M, Gustafsson JA. Characterization of the DNA-binding properties of the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Eur J Biochem. 1986 Apr 15;156(2):237–242. [PubMed]
  • Hansen JC, Gorski J. Conformational and electrostatic properties of unoccupied and liganded estrogen receptors determined by aqueous two-phase partitioning. Biochemistry. 1985 Oct 22;24(22):6078–6085. [PubMed]
  • Hansen JC, Gorski J. Conformational transitions of the estrogen receptor monomer. Effects of estrogens, antiestrogen, and temperature. J Biol Chem. 1986 Oct 25;261(30):13990–13996. [PubMed]
  • Hapgood J, Cuthill S, Denis M, Poellinger L, Gustafsson JA. Specific protein-DNA interactions at a xenobiotic-responsive element: copurification of dioxin receptor and DNA-binding activity. Proc Natl Acad Sci U S A. 1989 Jan;86(1):60–64. [PMC free article] [PubMed]
  • Harper PA, Golas CL, Okey AB. Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line. Cancer Res. 1988 May 1;48(9):2388–2395. [PubMed]
  • Henry EC, Rucci G, Gasiewicz TA. Characterization of multiple forms of the Ah receptor: comparison of species and tissues. Biochemistry. 1989 Jul 25;28(15):6430–6440. [PubMed]
  • Hirst M, Feldman D. Glucocorticoid regulation of 1,25(OH)2vitamin D3 receptors: divergent effects on mouse and rat intestine. Endocrinology. 1982 Oct;111(4):1400–1402. [PubMed]
  • Hoar SK, Blair A, Holmes FF, Boysen CD, Robel RJ, Hoover R, Fraumeni JF., Jr Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA. 1986 Sep 5;256(9):1141–1147. [PubMed]
  • Hoffman RE, Stehr-Green PA, Webb KB, Evans RG, Knutsen AP, Schramm WF, Staake JL, Gibson BB, Steinberg KK. Health effects of long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. JAMA. 1986 Apr 18;255(15):2031–2038. [PubMed]
  • Hong FD, Huang HJ, To H, Young LJ, Oro A, Bookstein R, Lee EY, Lee WH. Structure of the human retinoblastoma gene. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5502–5506. [PMC free article] [PubMed]
  • Huff JE, Moore JA, Saracci R, Tomatis L. Long-term hazards of polychlorinated dibenzodioxins and polychlorinated dibenzofurans. Environ Health Perspect. 1980 Jun;36:221–240. [PMC free article] [PubMed]
  • Israel DI, Whitlock JP., Jr Regulation of cytochrome P1-450 gene transcription by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells. J Biol Chem. 1984 May 10;259(9):5400–5402. [PubMed]
  • Israel DI, Estolano MG, Galeazzi DR, Whitlock JP., Jr Superinduction of cytochrome P1-450 gene transcription by inhibition of protein synthesis in wild type and variant mouse hepatoma cells. J Biol Chem. 1985 May 10;260(9):5648–5653. [PubMed]
  • Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 1990 Oct 18;347(6294):645–650. [PubMed]
  • Jakoby WB, Ziegler DM. The enzymes of detoxication. J Biol Chem. 1990 Dec 5;265(34):20715–20718. [PubMed]
  • Jensen EV, Suzuki T, Kawashima T, Stumpf WE, Jungblut PW, DeSombre ER. A two-step mechanism for the interaction of estradiol with rat uterus. Proc Natl Acad Sci U S A. 1968 Feb;59(2):632–638. [PMC free article] [PubMed]
  • Jones PB, Galeazzi DR, Fisher JM, Whitlock JP., Jr Control of cytochrome P1-450 gene expression by dioxin. Science. 1985 Mar 22;227(4693):1499–1502. [PubMed]
  • Jordan VC, Tate AC, Lyman SD, Gosden B, Wolf MF, Bain RR, Welshons WV. Rat uterine growth and induction of progesterone receptor without estrogen receptor translocation. Endocrinology. 1985 May;116(5):1845–1857. [PubMed]
  • Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y. Structure and drug inducibility of the human cytochrome P-450c gene. Eur J Biochem. 1986 Sep 1;159(2):219–225. [PubMed]
  • Kelling CK, Menahan LA, Peterson RE. Hepatic indices of thyroid status in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochem Pharmacol. 1987 Jan 15;36(2):283–291. [PubMed]
  • Kester JE, Gasiewicz TA. Characterization of the in vitro stability of the rat hepatic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Arch Biochem Biophys. 1987 Feb 1;252(2):606–625. [PubMed]
  • Kikuchi M. Autopsy of patients with yusho. Am J Ind Med. 1984;5(1-2):19–30. [PubMed]
  • King WJ, Greene GL. Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells. Nature. 1984 Feb 23;307(5953):745–747. [PubMed]
  • Klyzsejko-Stefanowicz L, Chiu JF, Tsai YH, Hnilica LS. Acceptor proteins in rat androgenic tissue chromatin. Proc Natl Acad Sci U S A. 1976 Jun;73(6):1954–1958. [PMC free article] [PubMed]
  • Knutson JC, Poland A. Response of murine epidermis to 2,3,7,8-tetrachlorodibenzo-p-dioxin: interaction of the ah and hr loci. Cell. 1982 Aug;30(1):225–234. [PubMed]
  • Knutson JC, Poland A. 2,3,7,8-Tetrachlorodibenzo-p-dioxin: examination of biochemical effects involved in the proliferation and differentiation of XB cells. J Cell Physiol. 1984 Oct;121(1):143–151. [PubMed]
  • Kost SL, Smith DF, Sullivan WP, Welch WJ, Toft DO. Binding of heat shock proteins to the avian progesterone receptor. Mol Cell Biol. 1989 Sep;9(9):3829–3838. [PMC free article] [PubMed]
  • Kurl RN, Lund J, Poellinger L, Gustafsson JA. Differential effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on nuclear RNA polymerase activity in the rat liver and thymus. Biochem Pharmacol. 1982 Aug 1;31(15):2459–2462. [PubMed]
  • Landers JP, Bunce NJ. Hepatic Ah receptor from the Wistar rat: role of solvation in receptor structure and inactivation. J Biochem Toxicol. 1990 Spring;5(1):33–39. [PubMed]
  • Landers JP, Piskorska-Pliszczynska J, Zacharewski T, Bunce NJ, Safe S. Photoaffinity labeling of the nuclear Ah receptor from mouse Hepa 1c1c7 cells using 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin. J Biol Chem. 1989 Nov 5;264(31):18463–18471. [PubMed]
  • Landers JP, Birse LM, Nakai JS, Winhall MJ, Bunce NJ. Chemically induced hepatic cytosol from the Sprague-Dawley rat: evidence for specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to components kinetically distinct from the Ah receptor. Toxicol Lett. 1990 May;51(3):295–302. [PubMed]
  • Lee WH, Shew JY, Hong FD, Sery TW, Donoso LA, Young LJ, Bookstein R, Lee EY. The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature. 1987 Oct 15;329(6140):642–645. [PubMed]
  • Legraverend C, Hannah RR, Eisen HJ, Owens IS, Nebert DW, Hankinson O. Regulatory gene product of the Ah locus. Characterization of receptor mutants among mouse hepatoma clones. J Biol Chem. 1982 Jun 10;257(11):6402–6407. [PubMed]
  • Leung HW, Poland A, Paustenbach DJ, Murray FJ, Andersen ME. Pharmacokinetics of [125I]-2-iodo-3,7,8-trichlorodibenzo-p-dioxin in mice: analysis with a physiological modeling approach. Toxicol Appl Pharmacol. 1990 May;103(3):411–419. [PubMed]
  • Lubet RA, Connolly G, Kouri RE, Nebert DW, Bigelow SW. Biological effects of the Sudan dyes. Role of the Ah cytosolic receptor. Biochem Pharmacol. 1983 Oct 15;32(20):3053–3058. [PubMed]
  • Madhukar BV, Brewster DW, Matsumura F. Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster. Proc Natl Acad Sci U S A. 1984 Dec;81(23):7407–7411. [PMC free article] [PubMed]
  • Manchester DK, Gordon SK, Golas CL, Roberts EA, Okey AB. Ah receptor in human placenta: stabilization by molybdate and characterization of binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, and benzo(a)pyrene. Cancer Res. 1987 Sep 15;47(18):4861–4868. [PubMed]
  • Marks TA, Kimmel GL, Staples RE. Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. I. Teratogenicity of 3, 3', 4, 4', 5, 5',-hexachlorobiphenyl. Toxicol Appl Pharmacol. 1981 Nov;61(2):269–276. [PubMed]
  • Mason ME, Okey AB. Cytosolic and nuclear binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the Ah receptor in extra-hepatic tissues of rats and mice. Eur J Biochem. 1982 Mar;123(1):209–215. [PubMed]
  • Mason G, Sawyer T, Keys B, Bandiera S, Romkes M, Piskorska-Pliszczynska J, Zmudzka B, Safe S. Polychlorinated dibenzofurans (PCDFs): correlation between in vivo and in vitro structure-activity relationships. Toxicology. 1985 Oct;37(1-2):1–12. [PubMed]
  • Mason G, Farrell K, Keys B, Piskorska-Pliszczynska J, Safe L, Safe S. Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships. Toxicology. 1986 Oct;41(1):21–31. [PubMed]
  • Mason G, Zacharewski T, Denomme MA, Safe L, Safe S. Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure-activity relationships. Toxicology. 1987 Jun;44(3):245–255. [PubMed]
  • Mastroiacovo P, Spagnolo A, Marni E, Meazza L, Bertollini R, Segni G, Borgna-Pignatti C. Birth defects in the Seveso area after TCDD contamination. JAMA. 1988 Mar 18;259(11):1668–1672. [PubMed]
  • May G. Chloracne from the accidental production of tetrachlorodibenzodioxin. Br J Ind Med. 1973 Jul;30(3):276–283. [PMC free article] [PubMed]
  • McConkey DJ, Hartzell P, Duddy SK, Håkansson H, Orrenius S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation. Science. 1988 Oct 14;242(4876):256–259. [PubMed]
  • Mebus CA, Reddy VR, Piper WN. Depression of rat testicular 17-hydroxylase and 17,20-lyase after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Biochem Pharmacol. 1987 Mar 1;36(5):727–731. [PubMed]
  • Mendel DB, Bodwell JE, Munck A. Glucocorticoid receptors lacking hormone-binding activity are bound in nuclei of ATP-depleted cells. Nature. 1986 Dec 4;324(6096):478–480. [PubMed]
  • Miller AG, Israel D, Whitlock JP., Jr Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity. J Biol Chem. 1983 Mar 25;258(6):3523–3527. [PubMed]
  • Miller PA, Ostrowski MC, Hager GL, Simons SS., Jr Covalent and noncovalent receptor-glucocorticoid complexes preferentially bind to the same regions of the long terminal repeat of murine mammary tumor virus proviral DNA. Biochemistry. 1984 Dec 18;23(26):6883–6889. [PubMed]
  • Milnes MH. Formation of 2,3,7,8-tetrachlorodibenzodioxin by thermal decomposition of sodium 2,4,5,-trichlorophenate. Nature. 1971 Aug 6;232(5310):395–396. [PubMed]
  • Mocarelli P, Marocchi A, Brambilla P, Gerthoux P, Young DS, Mantel N. Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental disaster near Seveso, Italy. JAMA. 1986 Nov 21;256(19):2687–2695. [PubMed]
  • Murdoch FE, Meier DA, Furlow JD, Grunwald KA, Gorski J. Estrogen receptor binding to a DNA response element in vitro is not dependent upon estradiol. Biochemistry. 1990 Sep 11;29(36):8377–8385. [PubMed]
  • Naito K, Isohashi F, Tsukanaka K, Horiuchi M, Okamoto K, Matsunaga T, Sakamoto Y. Effects of D- and L-thyroxine on the glucocorticoid binding capacity of adult rat liver. Biochem Biophys Res Commun. 1985 Jun 14;129(2):447–452. [PubMed]
  • Neal RA, Beatty PW, Gasiewicz TA. Studies of the mechanisms of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Ann N Y Acad Sci. 1979 May 31;320:204–213. [PubMed]
  • Nebert DW, Goujon FM, Gielen JE. Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse. Nat New Biol. 1972 Mar 29;236(65):107–110. [PubMed]
  • Nebert DW, Jensen NM, Perry JW, Oka T. Association between ornithine decarboxylase induction and the Ah locus in mice treated with polycyclic aromatic compounds. J Biol Chem. 1980 Jul 25;255(14):6836–6842. [PubMed]
  • Okey AB. Enzyme induction in the cytochrome P-450 system. Pharmacol Ther. 1990;45(2):241–298. [PubMed]
  • Okey AB, Vella LM. Elevated binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene to the Ah receptor in hepatic cytosols from phenobarbital-treated rats and mice. Biochem Pharmacol. 1984 Feb 15;33(4):531–538. [PubMed]
  • Okey AB, Bondy GP, Mason ME, Kahl GF, Eisen HJ, Guenthner TM, Nebert DW. Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation. J Biol Chem. 1979 Nov 25;254(22):11636–11648. [PubMed]
  • Okey AB, Bondy GP, Mason ME, Nebert DW, Forster-Gibson CJ, Muncan J, Dufresne MJ. Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines. J Biol Chem. 1980 Dec 10;255(23):11415–11422. [PubMed]
  • Okey AB, Dubé AW, Vella LM. Binding of benzo(a)pyrene and dibenz(a,h)anthracene to the Ah receptor in mouse and rat hepatic cytosols. Cancer Res. 1984 Apr;44(4):1426–1432. [PubMed]
  • Okey AB, Vella LM, Harper PA. Detection and characterization of a low affinity form of cytosolic Ah receptor in livers of mice nonresponsive to induction of cytochrome P1-450 by 3-methylcholanthrene. Mol Pharmacol. 1989 Jun;35(6):823–830. [PubMed]
  • Okret S, Poellinger L, Dong Y, Gustafsson JA. Down-regulation of glucocorticoid receptor mRNA by glucocorticoid hormones and recognition by the receptor of a specific binding sequence within a receptor cDNA clone. Proc Natl Acad Sci U S A. 1986 Aug;83(16):5899–5903. [PMC free article] [PubMed]
  • Olson JR, Gasiewicz TA, Neal RA. Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster. Toxicol Appl Pharmacol. 1980 Oct;56(1):78–85. [PubMed]
  • Ortí E, Mendel DB, Smith LI, Munck A. Agonist-dependent phosphorylation and nuclear dephosphorylation of glucocorticoid receptors in intact cells. J Biol Chem. 1989 Jun 15;264(17):9728–9731. [PubMed]
  • Owens IS. Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction. J Biol Chem. 1977 May 10;252(9):2827–2833. [PubMed]
  • Perdew GH. Association of the Ah receptor with the 90-kDa heat shock protein. J Biol Chem. 1988 Sep 25;263(27):13802–13805. [PubMed]
  • Perdew GH, Hollenback CE. Analysis of photoaffinity-labeled aryl hydrocarbon receptor heterogeneity by two-dimensional gel electrophoresis. Biochemistry. 1990 Jul 3;29(26):6210–6214. [PubMed]
  • Perdew GH, Poland A. Purification of the Ah receptor from C57BL/6J mouse liver. J Biol Chem. 1988 Jul 15;263(20):9848–9852. [PubMed]
  • Peterson RE, Madhukar BV, Yang KH, Matsumura F. Depression of adenosine triphosphatase activities in isolated liver surface membranes of 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated rats: correlation with effects on ouabain biliary excretion and bile flow. J Pharmacol Exp Ther. 1979 Aug;210(2):275–282. [PubMed]
  • Piskorska-Pliszczynska J, Keys B, Safe S, Newman MS. The cytosolic receptor binding affinities and AHH induction potencies of 29 polynuclear aromatic hydrocarbons. Toxicol Lett. 1986 Nov;34(1):67–74. [PubMed]
  • Poellinger L, Lund J, Gillner M, Hansson LA, Gustafsson JA. Physicochemical characterization of specific and nonspecific polyaromatic hydrocarbon binders in rat and mouse liver cytosol. J Biol Chem. 1983 Nov 25;258(22):13535–13542. [PubMed]
  • Poland A, Glover E. Chlorinated dibenzo-p-dioxins: potent inducers of delta-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase. II. A study of the structure-activity relationship. Mol Pharmacol. 1973 Nov;9(6):736–747. [PubMed]
  • Poland A, Glover E. 2,3,7,8-Tetrachlorodibenzo-p-dioxin: a potent inducer of -aminolevulinic acid synthetase. Science. 1973 Feb 2;179(4072):476–477. [PubMed]
  • Poland A, Glover E. An estimate of the maximum in vivo covalent binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to rat liver protein, ribosomal RNA, and DNA. Cancer Res. 1979 Sep;39(9):3341–3344. [PubMed]
  • Poland A, Glover E. Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats. Biochem Biophys Res Commun. 1987 Aug 14;146(3):1439–1449. [PubMed]
  • Poland A, Glover E. Ca2+-dependent proteolysis of the Ah receptor. Arch Biochem Biophys. 1988 Feb 15;261(1):103–111. [PubMed]
  • Poland A, Glover E. Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles. Mol Pharmacol. 1990 Sep;38(3):306–312. [PubMed]
  • Poland A, Knutson JC. 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol. 1982;22:517–554. [PubMed]
  • Poland AP, Glover E, Robinson JR, Nebert DW. Genetic expression of aryl hydrocarbon hydroxylase activity. Induction of monooxygenase activities and cytochrome P1-450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically "nonresponsive" to other aromatic hydrocarbons. J Biol Chem. 1974 Sep 10;249(17):5599–5606. [PubMed]
  • Poland A, Glover E, Kende AS. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem. 1976 Aug 25;251(16):4936–4946. [PubMed]
  • Poland A, Greenlee WF, Kende AS. Studies on the mechanism of action of the chlorinated dibenzo-p-dioxins and related compounds. Ann N Y Acad Sci. 1979 May 31;320:214–230. [PubMed]
  • Poland A, Glover E, Ebetino FH, Kende AS. Photoaffinity labeling of the Ah receptor. J Biol Chem. 1986 May 15;261(14):6352–6365. [PubMed]
  • Potter CL, Moore RW, Inhorn SL, Hagen TC, Peterson RE. Thyroid status and thermogenesis in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1986 Jun 15;84(1):45–55. [PubMed]
  • Pratt RM, Dencker L, Diewert VM. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced cleft palate in the mouse: evidence for alterations in palatal shelf fusion. Teratog Carcinog Mutagen. 1984;4(5):427–436. [PubMed]
  • Pratt WB. Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concepts. Mol Cell Endocrinol. 1990 Nov 12;74(1):C69–C76. [PubMed]
  • Prokipcak RD, Okey AB. Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys. 1988 Dec;267(2):811–828. [PubMed]
  • Prokipcak RD, Faber LE, Okey AB. Characterization of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: use of chemical crosslinking and a monoclonal antibody directed against a 59-kDa protein associated with steroid receptors. Arch Biochem Biophys. 1989 Nov 1;274(2):648–658. [PubMed]
  • Prokipcak RD, Denison MS, Okey AB. Nuclear Ah receptor from mouse hepatoma cells: effect of partial proteolysis on relative molecular mass and DNA-binding properties. Arch Biochem Biophys. 1990 Dec;283(2):476–483. [PubMed]
  • Puhvel SM, Ertl DC, Lynberg CA. Increased epidermal transglutaminase activity following 2,3,7,8-tetrachlorodibenzo-p-dioxin: in vivo and in vitro studies with mouse skin. Toxicol Appl Pharmacol. 1984 Mar 30;73(1):42–47. [PubMed]
  • Radanyi C, Renoir JM, Sabbah M, Baulieu EE. Chick heat-shock protein of Mr = 90,000, free or released from progesterone receptor, is in a dimeric form. J Biol Chem. 1989 Feb 15;264(5):2568–2573. [PubMed]
  • Rifkind AB, Gannon M, Gross SS. Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity. Biochem Biophys Res Commun. 1990 Nov 15;172(3):1180–1188. [PubMed]
  • Roberts L. Dioxin risks revisited. Science. 1991 Feb 8;251(4994):624–626. [PubMed]
  • Romkes M, Safe S. Comparative activities of 2,3,7,8-tetrachlorodibenzo-p-dioxin and progesterone as antiestrogens in the female rat uterus. Toxicol Appl Pharmacol. 1988 Mar 15;92(3):368–380. [PubMed]
  • Rories C, Spelsberg TC. Ovarian steroid action on gene expression: mechanisms and models. Annu Rev Physiol. 1989;51:653–681. [PubMed]
  • Rories C, Lau CK, Fink K, Spelsberg TC. Rapid inhibition of c-myc gene expression by a glucocorticoid in the avian oviduct. Mol Endocrinol. 1989 Jun;3(6):991–1001. [PubMed]
  • Rose JQ, Ramsey JC, Wentzler TH, Hummel RA, Gehring PJ. The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat. Toxicol Appl Pharmacol. 1976 May;36(2):209–226. [PubMed]
  • Ross P, Jr, Ruh TS. Binding of the estradiol-receptor complex to reconstituted nucleoacidic protein from calf uterus. Biochim Biophys Acta. 1984 May 15;782(1):18–25. [PubMed]
  • Safe SH. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu Rev Pharmacol Toxicol. 1986;26:371–399. [PubMed]
  • Sawyer T, Safe S. PCB isomers and congeners: induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells. Toxicol Lett. 1982 Sep;13(1-2):87–93. [PubMed]
  • Scheidereit C, Beato M. Contacts between hormone receptor and DNA double helix within a glucocorticoid regulatory element of mouse mammary tumor virus. Proc Natl Acad Sci U S A. 1984 May;81(10):3029–3033. [PMC free article] [PubMed]
  • Schmidt TJ, Miller-Diener A, Webb ML, Litwack G. Thermal activation of the purified rat hepatic glucocorticoid receptor. Evidence for a two-step mechanism. J Biol Chem. 1985 Dec 25;260(30):16255–16262. [PubMed]
  • Schmidt TJ, Diehl EE, Davidson CJ, Puk MJ, Webb ML, Litwack G. Effects of bovine pancreatic ribonuclease A, S protein, and S peptide on activation of purified rat hepatic glucocorticoid-receptor complexes. Biochemistry. 1986 Oct 7;25(20):5955–5961. [PubMed]
  • Schuh S, Yonemoto W, Brugge J, Bauer VJ, Riehl RM, Sullivan WP, Toft DO. A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src. J Biol Chem. 1985 Nov 15;260(26):14292–14296. [PubMed]
  • Seyfred MA, Gorski J. An interaction between the 5' flanking distal and proximal regulatory domains of the rat prolactin gene is required for transcriptional activation by estrogens. Mol Endocrinol. 1990 Aug;4(8):1226–1234. [PubMed]
  • Shu HP, Paustenbach DJ, Murray FJ. A critical evaluation of the use of mutagenesis, carcinogenesis, and tumor promotion data in a cancer risk assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Regul Toxicol Pharmacol. 1987 Mar;7(1):57–88. [PubMed]
  • Shyamala G. Estradiol receptors in mouse mammary tumors: absence of the transfer of bound estradiol from the cytoplasm to the nucleus. Biochem Biophys Res Commun. 1972 Feb 25;46(4):1623–1630. [PubMed]
  • Silbergeld EK, Gasiewicz TA. Dioxins and the Ah receptor. Am J Ind Med. 1989;16(4):455–474. [PubMed]
  • Simons SS, Jr, Sistare FD, Chakraborti PK. Steroid binding activity is retained in a 16-kDa fragment of the steroid binding domain of rat glucocorticoid receptors. J Biol Chem. 1989 Aug 25;264(24):14493–14497. [PubMed]
  • Sloop TC, Lucier GW. Dose-dependent elevation of Ah receptor binding by TCDD in rat liver. Toxicol Appl Pharmacol. 1987 May;88(3):329–337. [PubMed]
  • Smith AC, Elsasser MS, Harmon JM. Analysis of glucocorticoid receptor activation by high resolution two-dimensional electrophoresis of affinity-labeled receptor. J Biol Chem. 1986 Oct 5;261(28):13285–13292. [PubMed]
  • Smith DF, Faber LE, Toft DO. Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins. J Biol Chem. 1990 Mar 5;265(7):3996–4003. [PubMed]
  • Sogawa K, Fujisawa-Sehara A, Yamane M, Fujii-Kuriyama Y. Location of regulatory elements responsible for drug induction in the rat cytochrome P-450c gene. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8044–8048. [PMC free article] [PubMed]
  • Sparschu GL, Dunn FL, Rowe VK. Study of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Food Cosmet Toxicol. 1971 Jun;9(3):405–412. [PubMed]
  • Spelsberg TC. Nuclear binding of progesterone in chick oviduct. Multiple binding sites in vivo and transcriptional response. Biochem J. 1976 May 15;156(2):391–398. [PMC free article] [PubMed]
  • Spelsberg TC, Littlefield BA, Seelke R, Dani GM, Toyoda H, Boyd-Leinen P, Thrall C, Kon OL. Role of specific chromosomal proteins and DNA sequences in the nuclear binding sites for steroid receptors. Recent Prog Horm Res. 1983;39:463–517. [PubMed]
  • Stahl BU, Rozman K. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced appetite suppression in the Sprague-Dawley rat is not a direct effect on feed intake regulation in the brain. Toxicol Appl Pharmacol. 1990 Oct;106(1):158–162. [PubMed]
  • Strähle U, Klock G, Schütz G. A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression. Proc Natl Acad Sci U S A. 1987 Nov;84(22):7871–7875. [PMC free article] [PubMed]
  • Suskind RR, Hertzberg VS. Human health effects of 2,4,5-T and its toxic contaminants. JAMA. 1984 May 11;251(18):2372–2380. [PubMed]
  • Tai PK, Maeda Y, Nakao K, Wakim NG, Duhring JL, Faber LE. A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors. Biochemistry. 1986 Sep 9;25(18):5269–5275. [PubMed]
  • Thomas PE, Kouri RE, Hutton JJ. The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J. Biochem Genet. 1972 Apr;6(2):157–168. [PubMed]
  • Thunberg T, Ahlborg UG, Wahlström B. Comparison between the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and six other compounds on the vitamin A storage, the UDP-glucuronosyltransferase and the aryl hydrocarbon hydroxylase activity in the rat liver. Arch Toxicol. 1984 Mar;55(1):16–19. [PubMed]
  • Umbreit TH, Gallo MA. Physiological implications of estrogen receptor modulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Lett. 1988 Jul;42(1):5–14. [PubMed]
  • Waithe WI, Michaud M, Harper PA, Okey AB, Anderson A. The Ah receptor, cytochrome P450IA1 mRNA induction, and aryl hydrocarbon hydroxylase in a human lymphoblastoid cell line. Biochem Pharmacol. 1991 Jan 1;41(1):85–92. [PubMed]
  • Waterman ML, Adler S, Nelson C, Greene GL, Evans RM, Rosenfeld MG. A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the rat prolactin gene. Mol Endocrinol. 1988 Jan;2(1):14–21. [PubMed]
  • Whitlock JP., Jr The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Pharmacol Rev. 1987 Jun;39(2):147–161. [PubMed]
  • Whitlock JP., Jr Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu Rev Pharmacol Toxicol. 1990;30:251–277. [PubMed]
  • Whitlock JP, Jr, Galeazzi DR. 2,3,7,8-Tetrachlorodibenzo-p-dioxin receptors in wild type and variant mouse hepatoma cells. Nuclear location and strength of nuclear binding. J Biol Chem. 1984 Jan 25;259(2):980–985. [PubMed]
  • Whitlock JP, Jr, Denison MS, Fisher JM, Shen ES. Induction of hepatic cytochrome P450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Biol Med. 1989 Apr;6(2):169–178. [PubMed]
  • Wilhelmsson A, Cuthill S, Denis M, Wikström AC, Gustafsson JA, Poellinger L. The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein. EMBO J. 1990 Jan;9(1):69–76. [PMC free article] [PubMed]
  • Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 1990 Sep 21;62(6):1205–1215. [PubMed]

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