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Logo of jathtrainJournal URL: http://www.journalofathletictraining.org
Journal List > J Athl Train > v.40(2); Apr–Jun 2005

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J Athl Train. 2005 Apr–Jun; 40(2): 111–115.
PMCID: PMC1150224
Copyright National Athletic Trainers' Association, Inc.
Effects of Ibuprofen and High-Voltage Electric Stimulation on Acute Edema Formation After Blunt Trauma to Limbs of Rats
Michael G Dolan,* Paul Graves,* Chika Nakazawa,* Teresa Delano,* Alan Hutson,† and Frank C Mendel†
*Canisius College, Buffalo, NY
†State University of New York at Buffalo, Buffalo, NY
Michael G. Dolan, MA, ATC, CSCS; Paul Graves; Chika Nakazawa, BS; Teresa Delano, BS, ATC; Alan Hutson, PhD; and Frank C. Mendel, PhD, contributed to conception and design; analysis and interpretation of the data; and drafting, critical revision, and final approval of the article.
Address correspondence to Michael G. Dolan, MA, ATC, CSCS, Canisius College, 2001 Main Street, Buffalo, NY 14208. Address e-mail to mdolan/at/canisius.edu.
Abstract
Context: Ibuprofen is widely used to manage pain and inflammation after orthopaedic trauma, but its effect on acute swelling has not been investigated. Cathodal high-voltage pulsed current (CHVPC) at 120 pulses per second and 90% of visible motor threshold is known to curb edema formation after blunt trauma to the hind limbs of rats.
Objective: To examine the effects of ibuprofen, continuous CHVPC, and simultaneous ibuprofen and CHVPC on acute edema formation after blunt trauma to the hind limbs of rats.
Design: Randomized, parallel-group, repeated-measures design.
Setting: Laboratory animal facility.
Participants: A total of 21 3-month-old Zucker Lean rats (mass = 288 ± 55 g) were studied.
Intervention(s): We assessed the effects of ibuprofen, continuous CHVPC, and simultaneous ibuprofen and CHVPC on acute edema formation after blunt trauma to the hind limbs of rats.
Main Outcome Measure(s): Limb volumes were measured immediately before and after trauma and every 30 minutes over the 4 hours of the experiment.
Results: Volumes of treated limbs of all 3 experimental groups were smaller (P < .05) than those of untreated limbs, but no treatment was more effective than another.
Conclusions: Ibuprofen, CHVPC, and simultaneous ibuprofen and CHVPC effectively curbed edema after blunt injury by roughly 50% relative to untreated but similarly injured control limbs of rats.
Keywords: nonsteroidal anti-inflammatory drugs, electrotherapy, swelling, inflammation, modalities, animal model
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