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J Clin Pathol. 1979 November; 32(11): 1110–1120. | PMCID: PMC1145909 |
Immunoblastic lymphadenopathy: evolution into immunoblastic sarcoma. S Banik, R L Ward, and P S Hasleton Abstract A case of immunoblastic lymphadenopathy which underwent transformation into immunoblastic sarcoma is reported. A 64-year-old man presented with a rash, generalised lymphadenopathy, and hepatosplenomegaly. A cervical lymph node removed at biopsy showed the features of immunoblastic lymphadenopathy with the presence of heavy chain classes IgG, IgM, and IgA and both kappa and lambda light chain types in the cytoplasm of the immunoblasts. No such immunoglobulins could be demonstrated in the lymph nodes obtained at necropsy when the patient died of widespread immunoblastic sarcoma. The biological evolution and histogenesis of the disease are discussed and the current literature is reviewed. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (4.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - Bensa J, Faure J, Martin H, Sotto J, Schaerer R. Letter: Levamisole in angio-immunoblastic lymphadenopathy. Lancet. 1976 May 15;1(7968):1081. [PubMed]
- Curran RC, Jones EL. Immunoglobulin in Reed-Sternberg and Hodgkin cells. J Pathol. 1978 Sep;126(1):35–37. [PubMed]
- DAMESHEK W. "Immunoblasts" and "immunocytes"--an attempt at a functional nomenclature. Blood. 1963 Feb;21:243–245. [PubMed]
- Fisher RI, Jaffe ES, Braylan RC, Andersen JC, Tan HK. Immunoblastic lymphadenopathy. Evolution into a malignant lymphoma with plasmacytoid features. Am J Med. 1976 Oct;61(4):553–559. [PubMed]
- Flax MH. Editorial: Drug-induced autoimmunity. N Engl J Med. 1974 Aug 22;291(8):414–415. [PubMed]
- Frizzera G, Moran EM, Rappaport H. Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet. 1974 Jun 1;1(7866):1070–1073. [PubMed]
- Frizzera G, Moran EM, Rappaport H. Angio-immunoblastic lymphadenopathy. Diagnosis and clinical course. Am J Med. 1975 Dec;59(6):803–818. [PubMed]
- Hossfeld DK, Höffken K, Schmidt CG, Diedrichs H. Letter: Chromosome abnormalities in angioimmunoblastic lymphadenopathy. Lancet. 1976 Jan 24;1(7952):198. [PubMed]
- Iseman MD, Schwarz MI, Stanford RE. Interstitial pneumonia in angio-immunoblastic lymphadenopathy with dysproteinemia. A case report with special histopathologic studies. Ann Intern Med. 1976 Dec;85(6):752–755. [PubMed]
- Lapes MJ, Vivacqua RJ, Antoniades K. Letter: Immunoblactic lymphadenopathy associated with phenytoin (diphenylhydantoin). Lancet. 1976 Jan 24;1(7952):198. [PubMed]
- Lukes RJ, Collins RD. Immunologic characterization of human malignant lymphomas. Cancer. 1974 Oct;34(4 Suppl):suppl–suppl:1503. [PubMed]
- Lukes RJ, Tindle BH. Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease. N Engl J Med. 1975 Jan 2;292(1):1–8. [PubMed]
- Madri JA, Fromowitz F. Amyloid deposition in immunoblastic lymphadenopathy. Hum Pathol. 1978 Mar;9(2):157–162. [PubMed]
- Moses HL, Glade PR, Kasel JA, Rosenthal AS, Hirshaut Y, Chessin LN. Infectious mononucleosis: detection of herpeslike virus and reticular aggregates of small cytoplasmic particles in continuous lymphoid cell lines derived from peripheral blood. Proc Natl Acad Sci U S A. 1968 Jun;60(2):489–496. [PubMed]
- Nathwani BN, Rappaport H, Moran EM, Pangalis GA, Kim H. Malignant lymphoma arising in angioimmunoblastic lymphadenopathy. Cancer. 1978 Feb;41(2):578–606. [PubMed]
- Neiman RS, Dervan P, Haudenschild C, Jaffe R. Angioimmunoblastic lymphadenopathy: an ultrastructural and immunologic study with review of the literature. Cancer. 1978 Feb;41(2):507–518. [PubMed]
- Newcom SR, Kadin ME. Prednisone in treatment of allergen-associated angio-immunoblastic lymphadenopathy. Lancet. 1979 Mar 3;1(8114):462–464. [PubMed]
- Paulutke M, Khilanani P, Weise R. Immunologic and electronmicroscopic characteristics of a case of immunoblastic lymphadenopathy. Am J Clin Pathol. 1976 Jun;65(6):929–941. [PubMed]
- Rudders RA, DeLellis R. Immunoblastic lymphadenopathy. A mixed proliferation of T and B lymphocytes. Am J Clin Pathol. 1977 Oct;68(4):518–521. [PubMed]
- Salmon SE, Seligmann M. B-cell neoplasia in man. Lancet. 1974 Nov 23;2(7891):1230–1233. [PubMed]
- Spector JI, Miller S. Immunoblastic lymphadenopathy. A report of two cases. JAMA. 1977 Sep 19;238(12):1263–1265. [PubMed]
- Volk SL, Monteleone PL, Knight WA. Letter: Chromosomes in AILD. N Engl J Med. 1975 May 1;292(18):975. [PubMed]
- Weisenburger DD. Immunoblastic lymphadenopathy associated with methyldopa therapy: a case report. Cancer. 1978 Nov;42(5):2322–2327. [PubMed]
- Weisenburger D, Armitage J, Dick F. Immunoblastic lymphadenopathy with pulmonary infiltrates, hypocomplementemia and vasculitis. A hyperimmune syndrome. Am J Med. 1977 Dec;63(6):849–854. [PubMed]
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