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Journal List > J Clin Pathol > v.31(12); Dec 1978

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J Clin Pathol. 1978 December; 31(12): 1143–1146.
PMCID: PMC1145520
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Immunoglobulin and complement in normal skin.
W K Blenkinsopp, R J Clayton, and G P Haffenden
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Abstract
Cryostat sections of normal skin from 57 white adults were examined by direct and indirect immunofluorescence for immunoglobulins, complement factors, and transferrin. The results for basement membrane zone (BMX) were significantly different for the 11 face and 46 non-face biopsies: in the face, IgM was found in five, IgG in two, IgA in one, and C3 in none, whereas, in non-face, IgM was present in six, IgG in none, IgA in one, and C3 in five. The results for dermal vessel walls (DV) were not apparently different for face and non-face; in the 57 biopsies IgM was present in one, IgG in none, IgA in one, and C3 in one. The 11 biopsies from the face and 26 of the non-face biopsies were examined further. No IgD or C4 was identified, but one case (scalp) showed BMZ Clq, properdin, and transferrin, and in two cases (one face, one non-face) DV properdin was found. Cytoid bodies (IgM and IgA) were present in moderate numbers in one case; all other positive reactions were finely granular.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Abell E, Black MM, Marks R. Immunoglobulin and complement deposits in the skin in inflammatory facial dermatoses--an immunofluorescence study. Br J Dermatol. 1974 Sep;91(3):281–286. [PubMed]
  • Abell E, Presbury DG, Marks R, Ramnarain D. The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus. Br J Dermatol. 1975 Jul;93(1):17–24. [PubMed]
  • Baart de la Faille-Kuyper EH, van der Meer JB, Baart de la Faille H. An immunohistochemical study of the skin of healthy individuals. Acta Derm Venereol. 1974;54(4):271–274. [PubMed]
  • Burnham TK, Fine G. The immunofluorescent "band" test for lupus erythematosus. Br J Dermatol. 1971 Feb;84(2):176–177. [PubMed]
  • Cormane RH, Giannetti A. IgD in various dermatoses; immunofluorescence studies. Br J Dermatol. 1971 Jun;84(6):523–533. [PubMed]
  • Cream JJ, Bryceson AD, Ryder G. Disappearance of immunoglobulin and complement from the Arthus reaction and its relevance to studies of vasculitis in man. Br J Dermatol. 1971 Feb;84(2):106–109. [PubMed]
  • Jablonska S, Chorzelski T, Maciejowska E. The scope and limitations of the immunofluorescence method in the diagnosis of lupus erythematosus. Br J Dermatol. 1970 Aug;83(2):242–247. [PubMed]
  • Sams WM, Jr, Claman HN, Kohler PF, McIntosh RM, Small P, Mass MF. Human necrotizing vasculitis: immunoglobulins and complement in vessel walls of cutaneous lesions and normal skin. J Invest Dermatol. 1975 Jun;64(6):441–445. [PubMed]
  • Schrager MA, Rothfield NF. Clinical significance of serum properdin levels and properdin deposition in the dermal-epidermal junction in systemic lupus erythematosus. J Clin Invest. 1976 Jan;57(1):212–221. [PubMed]
  • Schroeter AL, Conn DL, Jordon RE. Immunoglobulin and complement deposition in skin of rheumatoid arthritis and systemic lupus erythematosus patients. Ann Rheum Dis. 1976 Aug;35(4):321–326. [PubMed]
  • Schroeter AL, Copeman PW, Jordon RE, Sams WM, Jr, Winkelmann RK. Immunofluorescence of cutaneous vasculitis associated with systemic disease. Arch Dermatol. 1971 Sep;104(3):254–259. [PubMed]
  • Tuffanelli DL. Cutaneous immunopathology: recent observations. J Invest Dermatol. 1975 Jul;65(1):143–153. [PubMed]
  • Weidner F. Immunofluorescent investigations in cutaneous vasculitis. II. Histotopical demonstration of IgD and fibrin. Arch Dermatol Res. 1975 Dec 10;254(2):215–224. [PubMed]
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