• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of biochemjBJ Latest papers and much more!
Biochem J. Jul 1, 1985; 229(1): 265–268.
PMCID: PMC1145176

Differential binding of glycine- and taurine-conjugated bile acids to insoluble calcium phosphate.


It is demonstrated that bile acids bind to insoluble calcium phosphate at pH values beyond 5.5. Significant binding occurs with glycine-conjugated dihydroxy bile acids. Results indicate that these bile acids are bound in a micellar mode. Taurine conjugation almost completely inhibits the binding of these bile acids to insoluble calcium phosphate. Since glycine-conjugated dihydroxy bile acids are predominant in the rabbit, but not in the rat, our results suggest an explanation for the intriguing species-dependence of casein-induced hypercholesterolaemia, which is high in the rabbit but absent in the rat.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (539K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Carey MC, Small DM, Bliss CM. Lipid digestion and absorption. Annu Rev Physiol. 1983;45:651–677. [PubMed]
  • Coleman R, Iqbal S, Godfrey PP, Billington D. Membranes and bile formation. Composition of several mammalian biles and their membrane-damaging properties. Biochem J. 1979 Jan 15;178(1):201–208. [PMC free article] [PubMed]
  • Danielsson H, Sjövall J. Bile acid metabolism. Annu Rev Biochem. 1975;44:233–253. [PubMed]
  • Kempen HJ, Vos-Van Holstein MP, de Lange J. Bile acids and lipids in isolated rat hepatocytes: content, synthesis, and release, as affected by cholestyramine treatment of the donor rats. J Lipid Res. 1982 Aug;23(6):823–830. [PubMed]
  • Packard CJ, Shepherd J. The hepatobiliary axis and lipoprotein metabolism: effects of bile acid sequestrants and ileal bypass surgery. J Lipid Res. 1982 Nov;23(8):1081–1098. [PubMed]
  • Rajagopalan N, Lindenbaum S. The binding of Ca2+ to taurine and glycine-conjugated bile salt micelles. Biochim Biophys Acta. 1982 Apr 15;711(1):66–74. [PubMed]
  • Roda A, Hofmann AF, Mysels KJ. The influence of bile salt structure on self-association in aqueous solutions. J Biol Chem. 1983 May 25;258(10):6362–6370. [PubMed]
  • Turley SD, Dietschy JM. Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile. J Lipid Res. 1978 Sep;19(7):924–928. [PubMed]
  • Van der Meer R. Is the hypercholesterolemic effect of dietary casein related to its phosphorylation state? Atherosclerosis. 1983 Dec;49(3):339–341. [PubMed]
  • West CE, Beynen AC, Terpstra AH, Scholz KE, Carroll KK, Woodward CJ. The nature of dietary protein and serum cholesterol. Atherosclerosis. 1983 Feb;46(2):253–256. [PubMed]
  • Williamson BW, Percy-Robb IW. The interaction of calcium ions with glycocholate micelles in aqueous solution. Biochem J. 1979 Jul 1;181(1):61–66. [PMC free article] [PubMed]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...