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Biochem J. Jul 1, 1985; 229(1): 265–268.
PMCID: PMC1145176

Differential binding of glycine- and taurine-conjugated bile acids to insoluble calcium phosphate.

Abstract

It is demonstrated that bile acids bind to insoluble calcium phosphate at pH values beyond 5.5. Significant binding occurs with glycine-conjugated dihydroxy bile acids. Results indicate that these bile acids are bound in a micellar mode. Taurine conjugation almost completely inhibits the binding of these bile acids to insoluble calcium phosphate. Since glycine-conjugated dihydroxy bile acids are predominant in the rabbit, but not in the rat, our results suggest an explanation for the intriguing species-dependence of casein-induced hypercholesterolaemia, which is high in the rabbit but absent in the rat.

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Selected References

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  • Carey MC, Small DM, Bliss CM. Lipid digestion and absorption. Annu Rev Physiol. 1983;45:651–677. [PubMed]
  • Coleman R, Iqbal S, Godfrey PP, Billington D. Membranes and bile formation. Composition of several mammalian biles and their membrane-damaging properties. Biochem J. 1979 Jan 15;178(1):201–208. [PMC free article] [PubMed]
  • Danielsson H, Sjövall J. Bile acid metabolism. Annu Rev Biochem. 1975;44:233–253. [PubMed]
  • Kempen HJ, Vos-Van Holstein MP, de Lange J. Bile acids and lipids in isolated rat hepatocytes: content, synthesis, and release, as affected by cholestyramine treatment of the donor rats. J Lipid Res. 1982 Aug;23(6):823–830. [PubMed]
  • Packard CJ, Shepherd J. The hepatobiliary axis and lipoprotein metabolism: effects of bile acid sequestrants and ileal bypass surgery. J Lipid Res. 1982 Nov;23(8):1081–1098. [PubMed]
  • Rajagopalan N, Lindenbaum S. The binding of Ca2+ to taurine and glycine-conjugated bile salt micelles. Biochim Biophys Acta. 1982 Apr 15;711(1):66–74. [PubMed]
  • Roda A, Hofmann AF, Mysels KJ. The influence of bile salt structure on self-association in aqueous solutions. J Biol Chem. 1983 May 25;258(10):6362–6370. [PubMed]
  • Turley SD, Dietschy JM. Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile. J Lipid Res. 1978 Sep;19(7):924–928. [PubMed]
  • Van der Meer R. Is the hypercholesterolemic effect of dietary casein related to its phosphorylation state? Atherosclerosis. 1983 Dec;49(3):339–341. [PubMed]
  • West CE, Beynen AC, Terpstra AH, Scholz KE, Carroll KK, Woodward CJ. The nature of dietary protein and serum cholesterol. Atherosclerosis. 1983 Feb;46(2):253–256. [PubMed]
  • Williamson BW, Percy-Robb IW. The interaction of calcium ions with glycocholate micelles in aqueous solution. Biochem J. 1979 Jul 1;181(1):61–66. [PMC free article] [PubMed]

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