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J Clin Pathol. 1989 January; 42(1): 69–71. | PMCID: PMC1141794 |
Circulating immune complexes after splenectomy. E A Donadi, I F Carvalho, and R P Falcão Department of Clinical Medicine, School of Medicine, Ribeirão Preto, Brazil. Abstract Circulating immune complexes were evaluated in 25 patients (age range 10 to 46 years) who had undergone splenectomy for non-malignant conditions by studying a polyethylene glycol insoluble serum fraction. Although the extent of binding to Clq was within normal limits, these patients had increased concentrations of factor B in the immune complex serum fraction. These findings indicate that an unusual type of circulating immune complex may be detected after splenectomy, suggesting a possible role for the spleen in the removal of circulating immune complexes. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (418K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Theofilopoulos AN, Dixon FJ. The biology and detection of immune complexes. Adv Immunol. 1979;28:89–220. [PubMed]
- McDougal JS, McDuffie FC. Immune complexes in man: detection and clinical significance. Adv Clin Chem. 1985;24:1–60. [PubMed]
- Inman RD, Day NK. Immunologic and clinical aspects of immune complex disease. Am J Med. 1981 May;70(5):1097–1106. [PubMed]
- Mannik M. Pathophysiology of circulating immune complexes. Arthritis Rheum. 1982 Jul;25(7):783–787. [PubMed]
- Hosea SW, Brown EJ, Hamburger MI, Frank MM. Opsonic requirements for intravascular clearance after splenectomy. N Engl J Med. 1981 Jan 29;304(5):245–250. [PubMed]
- Yousaf N, Howard JC, Williams BD. Studies in cobra venom factor treated rats of antibody coated erythrocyte clearance by the spleen: differential influence of red blood cell antigen number on the inhibitory effects of immune complexes on Fc dependent clearance. Clin Exp Immunol. 1986 Dec;66(3):654–660. [PubMed]
- Kragballe K, Nielsen JL, Sølling J, Ellegaard J. Monocyte cytotoxicity after splenectomy. Scand J Haematol. 1981 Oct;27(4):271–278. [PubMed]
- Nielsen JL, Buskjaer L, Lamm LU, Sølling J, Ellegaard J. Complement studies in splenectomized patients. Scand J Haematol. 1983 Mar;30(3):194–200. [PubMed]
- Zago MA, Bottura C. Splenic function in sickle-cell diseases. Clin Sci (Lond). 1983 Sep;65(3):297–302. [PubMed]
- Hartree EF. Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal Biochem. 1972 Aug;48(2):422–427. [PubMed]
- MCGILVERY RW, MOKRASCH LC. Purification and properties of fructose-1, 6-diphosphatase. J Biol Chem. 1956 Aug;221(2):909–917. [PubMed]
- Levinson SS, Goldman J. Measurement of circulating Clq precipitable immune complexes by a nephelometric type assay after polyethylene glycol extraction in model system. Am J Clin Pathol. 1983 Apr;79(4):451–457. [PubMed]
- Chudwin DS, Korenblit AD, Kingzette M, Artrip S, Rao S. Increased activation of the alternative complement pathway in sickle cell disease. Clin Immunol Immunopathol. 1985 Oct;37(1):93–97. [PubMed]
- Frank MM, Hamburger MI, Lawley TJ, Kimberly RP, Plotz PH. Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med. 1979 Mar 8;300(10):518–523. [PubMed]
- Lockwood CM, Worlledge S, Nicholas A, Cotton C, Peters DK. Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange. N Engl J Med. 1979 Mar 8;300(10):524–530. [PubMed]
- Hamburger MI, Moutsopoulos HM, Lawley TJ, Frank MM. Sjögren's syndrome: a defect in reticuloendothelial system Fc-receptor-specific clearance. Ann Intern Med. 1979 Oct;91(4):534–538. [PubMed]
- Clarkson AR, Woodroffe AJ, Aarons I, Hiki Y, Hale G. IgA nephropathy. Annu Rev Med. 1987;38:157–168. [PubMed]
- Corrigan JJ, Jr, Van Wyck DB, Crosby WH. Clinical disorders of splenic function: the spectrum from asplenism to hypersplenism. Lymphology. 1983 Jun;16(2):101–106. [PubMed]
- McCoy RC. Ultrastructural alterations in the kidney of patients with sickle cell disease and the nephrotic syndrome. Lab Invest. 1969 Aug;21(2):85–95. [PubMed]
- Elfenbein IB, Patchefsky A, Schwartz W, Weinstein AG. Pathology of the glomerulus in sickle cell anemia with and without nephrotic syndrome. Am J Pathol. 1974 Dec;77(3):357–374. [PubMed]
- Strauss J, Pardo V, Koss MN, Griswold W, McIntosh RM. Nephropathy associated with sickle cell anemia: an autologous immune complex nephritis. I. Studies on nature of glomerular-bound antibody and antigen identification in a patient with sickle cell disease and immune deposit glomerulonephritis. Am J Med. 1975 Mar;58(3):382–387. [PubMed]
- Pardo V, Strauss J, Kramer H, Ozawa T, McIntosh RM. Nephropathy associated with sickle cell anemia: an autologous immune complex nephritis. II. Clinicopathologic study of seven patients. Am J Med. 1975 Nov;59(5):650–659. [PubMed]
- Strauss J, Zilleruelo G, Abitbol C. The kidney and hemoglobin S. Nephron. 1986;43(4):241–245. [PubMed]
- McVicar M, Chandra M. Pathogenic mechanisms in the nephrotic syndrome of childhood. Adv Pediatr. 1985;32:269–286. [PubMed]
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