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J Clin Pathol. 1988 July; 41(7): 763–767. | PMCID: PMC1141585 |
Refractory myelodysplastic anaemias with hypocellular bone marrow. Y Yoshida, S Oguma, H Uchino, and T Maekawa Department of Medicine, Kyoto University, Japan. Abstract Thirty three patients with refractory myelodysplastic anaemias (RMDA) with marrow hypocellularity were reviewed to see whether they differed from those with normocellular or hypercellular marrows. The median age was 65 years with a male:female ratio of 26:7. There were 11 cases of refractory anaemia (RA), four of refractory anaemia with ringed sideroblasts (RARS), and 18 of refractory anaemia with excess of blasts (RAEB). All presented with peripheral cytopenias, mostly pancytopenia or bicytopenia dysplasia in one or more cell lineages, and a marrow biopsy specimen with less than normal numbers of nucleated cells for the age. Twenty four patients died, including 14 of the 16 who developed acute non-lymphocytic leukaemia (ANLL). The results suggest that patients with hypocellular RMDA have a similar prognosis to those with normocellular or hypercellular marrows at presentation. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (628K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Greenberg PL. Biologic abnormalities in the myelodysplastic syndromes and myeloproliferative disorders. Nippon Ketsueki Gakkai Zasshi. 1986 Dec;49(8):1509–1527. [PubMed]
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