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J Clin Pathol. 1987 January; 40(1): 53–60. | PMCID: PMC1140828 |
Light chains and the kidney. J R Bradley, S Thiru, and D B Evans Abstract Five cases of renal impairment caused by the deposition of light chains in the kidney in association with various immunoproliferative disorders are reported. Light microscopy, immunohistochemistry, and electron microscopy were undertaken and different clinical courses were studied, resulting in variable influences of treatment. Light chain deposition is an important cause of renal impairment and requires special histological techniques for its recognition. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - Defronzo RA, Humphrey RL, Wright JR, Cooke CR. Acute renal failure in multiple myeloma. Medicine (Baltimore). 1975 May;54(3):209–223. [PubMed]
- Tubbs RR, Gephardt GN, McMahon JT, Hall PM, Valenzuela R, Vidt DG. Light chain nephropathy. Am J Med. 1981 Aug;71(2):263–269. [PubMed]
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- Preud'homme JL, Morel-Maroger L, Brouet JC, Cerf M, Mignon F, Guglielmi P, Seligmann M. Synthesis of abnormal immunoglobulins in lymphoplasmacytic disorders with visceral light chain deposition. Am J Med. 1980 Nov;69(5):703–710. [PubMed]
- Coward RA, Delamore IW, Mallick NP, Robinson EL. The importance of urinary immunoglobulin light chain isoelectric point (pI) in nephrotoxicity in multiple myeloma. Clin Sci (Lond). 1984 Feb;66(2):229–232. [PubMed]
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