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Biochem J. Aug 15, 1993; 294(Pt 1): 1–14.
PMCID: PMC1134557

Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement.

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  • Allan D, Michell RH. Accumulation of 1,2-diacylglycerol in the plasma membrane may lead to echinocyte transformation of erythrocytes. Nature. 1975 Nov 27;258(5533):348–349. [PubMed]
  • Allan D, Thomas P, Michell RH. Rapid transbilayer diffusion of 1,2-diacylglycerol and its relevance to control of membrane curvature. Nature. 1978 Nov 16;276(5685):289–290. [PubMed]
  • Andrick C, Bröring K, Deuticke B, Haest CW. Fast translocation of phosphatidylcholine to the outer membrane leaflet after its synthesis at the inner membrane surface in human erythrocytes. Biochim Biophys Acta. 1991 May 7;1064(2):235–241. [PubMed]
  • Aroeti B, Gutman O, Henis YI. Transient alterations in the lateral mobility of erythrocyte membrane components during Sendai virus-mediated fusion. J Biol Chem. 1992 Jul 5;267(19):13272–13277. [PubMed]
  • Backer JM, Dawidowicz EA. Transmembrane movement of cholesterol in small unilamellar vesicles detected by cholesterol oxidase. J Biol Chem. 1981 Jan 25;256(2):586–588. [PubMed]
  • Backer JM, Dawidowicz EA. Reconstitution of a phospholipid flippase from rat liver microsomes. Nature. 327(6120):341–343. [PubMed]
  • Barsukov LI, Bergelson LD, Spiess M, Hauser H, Semenza G. Phospholipid topology and flip-flop in intestinal brush-border membrane. Biochim Biophys Acta. 1986 Nov 6;862(1):87–99. [PubMed]
  • Bazzi MD, Nelsestuen GL. Highly sequential binding of protein kinase C and related proteins to membranes. Biochemistry. 1991 Aug 13;30(32):7970–7977. [PubMed]
  • Bazzi MD, Youakim MA, Nelsestuen GL. Importance of phosphatidylethanolamine for association of protein kinase C and other cytoplasmic proteins with membranes. Biochemistry. 1992 Feb 4;31(4):1125–1134. [PubMed]
  • Beleznay Z, Zachowski A, Devaux PF, Navazo MP, Ott P. ATP-dependent aminophospholipid translocation in erythrocyte vesicles: stoichiometry of transport. Biochemistry. 1993 Mar 30;32(12):3146–3152. [PubMed]
  • Ben-Bassat I, Bensch KG, Schrier SL. Drug-induced erythrocyte membrane internalization. J Clin Invest. 1972 Jul;51(7):1833–1844. [PMC free article] [PubMed]
  • Bergmann WL, Dressler V, Haest CW, Deuticke B. Reorientation rates and asymmetry of distribution of lysophospholipids between the inner and outer leaflet of the erythrocyte membrane. Biochim Biophys Acta. 1984 May 30;772(3):328–336. [PubMed]
  • Bevers EM, Comfurius P, Zwaal RF. Changes in membrane phospholipid distribution during platelet activation. Biochim Biophys Acta. 1983 Dec 7;736(1):57–66. [PubMed]
  • Bevers EM, Tilly RH, Senden JM, Comfurius P, Zwaal RF. Exposure of endogenous phosphatidylserine at the outer surface of stimulated platelets is reversed by restoration of aminophospholipid translocase activity. Biochemistry. 1989 Mar 21;28(6):2382–2387. [PubMed]
  • Bishop WR, Bell RM. Assembly of the endoplasmic reticulum phospholipid bilayer: the phosphatidylcholine transporter. Cell. 1985 Aug;42(1):51–60. [PubMed]
  • Bitbol M, Devaux PF. Measurement of outward translocation of phospholipids across human erythrocyte membrane. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6783–6787. [PMC free article] [PubMed]
  • Bitbol M, Fellmann P, Zachowski A, Devaux PF. Ion regulation of phosphatidylserine and phosphatidylethanolamine outside-inside translocation in human erythrocytes. Biochim Biophys Acta. 1987 Nov 13;904(2):268–282. [PubMed]
  • Blau L, Bittman R. Cholesterol distribution between the two halves of the lipid bilayer of human erythrocyte ghost membranes. J Biol Chem. 1978 Dec 10;253(23):8366–8368. [PubMed]
  • Bloj B, Zilversmit DB. Asymmetry and transposition rates of phosphatidylcholine in rat erythrocyte ghosts. Biochemistry. 1976 Mar 23;15(6):1277–1283. [PubMed]
  • Bloj B, Zilversmit DB. Complete exchangeability of cholesterol in phosphatidylcholine/cholesterol vesicles of different degrees of unsaturation. Biochemistry. 1977 Sep 6;16(18):3943–3948. [PubMed]
  • Bloj B, Zilversmit DB. Transposition and distribution of cholesterol in rat erythrocytes. Proc Soc Exp Biol Med. 1977 Dec;156(3):539–543. [PubMed]
  • Blumenfeld N, Zachowski A, Galacteros F, Beuzard Y, Devaux PF. Transmembrane mobility of phospholipids in sickle erythrocytes: effect of deoxygenation on diffusion and asymmetry. Blood. 1991 Feb 15;77(4):849–854. [PubMed]
  • Boegheim JP, Jr, Van Linde M, Op den Kamp JA, Roelofsen B. The sphingomyelin pools in the outer and inner layer of the human erythrocyte membrane are composed of different molecular species. Biochim Biophys Acta. 1983 Nov 23;735(3):438–442. [PubMed]
  • Bollen IC, Higgins JA. Phospholipid asymmetry in rough- and smooth-endoplasmic-reticulum membranes of untreated and phenobarbital-treated rat liver. Biochem J. 1980 Sep 1;189(3):475–480. [PMC free article] [PubMed]
  • Brasaemle DL, Robertson AD, Attie AD. Transbilayer movement of cholesterol in the human erythrocyte membrane. J Lipid Res. 1988 Apr;29(4):481–489. [PubMed]
  • Bretscher MS. Asymmetrical lipid bilayer structure for biological membranes. Nat New Biol. 1972 Mar 1;236(61):11–12. [PubMed]
  • Bretscher MS. Phosphatidyl-ethanolamine: differential labelling in intact cells and cell ghosts of human erythrocytes by a membrane-impermeable reagent. J Mol Biol. 1972 Nov 28;71(3):523–528. [PubMed]
  • Brodsky FM. Living with clathrin: its role in intracellular membrane traffic. Science. 1988 Dec 9;242(4884):1396–1402. [PubMed]
  • Bröring K, Haest CW, Deuticke B. Translocation of oleic acid across the erythrocyte membrane. Evidence for a fast process. Biochim Biophys Acta. 1989 Nov 27;986(2):321–331. [PubMed]
  • Buckland RM, Radda GK, Shennan CD. Accessibility of phospholipids in the chromaffin granule membrane. Biochim Biophys Acta. 1978 Nov 16;513(3):321–337. [PubMed]
  • Burger KN, Verkleij AJ. Membrane fusion. Experientia. 1990 Jun 15;46(6):631–644. [PubMed]
  • Burger KN, Nieva JL, Alonso A, Verkleij AJ. Phospholipase C activity-induced fusion of pure lipid model membranes. A freeze fracture study. Biochim Biophys Acta. 1991 Sep 30;1068(2):249–253. [PubMed]
  • Burgoyne RD, Geisow MJ. The annexin family of calcium-binding proteins. Review article. Cell Calcium. 1989 Jan;10(1):1–10. [PubMed]
  • Bütikofer P, Lin ZW, Chiu DT, Lubin B, Kuypers FA. Transbilayer distribution and mobility of phosphatidylinositol in human red blood cells. J Biol Chem. 1990 Sep 25;265(27):16035–16038. [PubMed]
  • Cabral DJ, Small DM, Lilly HS, Hamilton JA. Transbilayer movement of bile acids in model membranes. Biochemistry. 1987 Apr 7;26(7):1801–1804. [PubMed]
  • Calvez JY, Zachowski A, Herrmann A, Morrot G, Devaux PF. Asymmetric distribution of phospholipids in spectrin-poor erythrocyte vesicles. Biochemistry. 1988 Jul 26;27(15):5666–5670. [PubMed]
  • Chandra R, Joshi PC, Bajpai VK, Gupta CM. Membrane phospholipid organization in calcium-loaded human erythrocytes. Biochim Biophys Acta. 1987 Aug 20;902(2):253–262. [PubMed]
  • Chap HJ, Zwaal RF, van Deenen LL. Action of highly purified phospholipases on blood platelets. Evidence for an asymmetric distribution of phospholipids in the surface membrane. Biochim Biophys Acta. 1977 Jun 2;467(2):146–164. [PubMed]
  • Colleau M, Hervé P, Fellmann P, Devaux PF. Transmembrane diffusion of fluorescent phospholipids in human erythrocytes. Chem Phys Lipids. 1991 Jan-Feb;57(1):29–37. [PubMed]
  • Comfurius P, Senden JM, Tilly RH, Schroit AJ, Bevers EM, Zwaal RF. Loss of membrane phospholipid asymmetry in platelets and red cells may be associated with calcium-induced shedding of plasma membrane and inhibition of aminophospholipid translocase. Biochim Biophys Acta. 1990 Jul 24;1026(2):153–160. [PubMed]
  • Connor J, Schroit AJ. Determination of lipid asymmetry in human red cells by resonance energy transfer. Biochemistry. 1987 Aug 11;26(16):5099–5105. [PubMed]
  • Connor J, Schroit AJ. Transbilayer movement of phosphatidylserine in erythrocytes: inhibition of transport and preferential labeling of a 31,000-dalton protein by sulfhydryl reactive reagents. Biochemistry. 1988 Feb 9;27(3):848–851. [PubMed]
  • Connor J, Schroit AJ. Transbilayer movement of phosphatidylserine in nonhuman erythrocytes: evidence that the aminophospholipid transporter is a ubiquitous membrane protein. Biochemistry. 1989 Dec 12;28(25):9680–9685. [PubMed]
  • Connor J, Bucana C, Fidler IJ, Schroit AJ. Differentiation-dependent expression of phosphatidylserine in mammalian plasma membranes: quantitative assessment of outer-leaflet lipid by prothrombinase complex formation. Proc Natl Acad Sci U S A. 1989 May;86(9):3184–3188. [PMC free article] [PubMed]
  • Connor J, Gillum K, Schroit AJ. Maintenance of lipid asymmetry in red blood cells and ghosts: effect of divalent cations and serum albumin on the transbilayer distribution of phosphatidylserine. Biochim Biophys Acta. 1990 Jun 11;1025(1):82–86. [PubMed]
  • Connor J, Pak CH, Zwaal RF, Schroit AJ. Bidirectional transbilayer movement of phospholipid analogs in human red blood cells. Evidence for an ATP-dependent and protein-mediated process. J Biol Chem. 1992 Sep 25;267(27):19412–19417. [PubMed]
  • Crain RC, Marinetti GV. Phospholipid topology of the inner mitochondrial membrane of rat liver. Biochemistry. 1979 May 29;18(11):2407–2414. [PubMed]
  • Crain RC, Zilversmit DB. Two nonspecific phospholipid exchange proteins from beef liver. 2. Use in studying the asymmetry and transbilayer movement of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin in intact rat erythrocytes. Biochemistry. 1980 Apr 1;19(7):1440–1447. [PubMed]
  • Creutz CE, Pazoles CJ, Pollard HB. Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules. J Biol Chem. 1978 Apr 25;253(8):2858–2866. [PubMed]
  • Cribier S, Morrot G, Neumann JM, Devaux PF. Lateral diffusion of erythrocyte phospholipids in model membranes comparison between inner and outer leaflet components. Eur Biophys J. 1990;18(1):33–41. [PubMed]
  • Cribier S, Sainte-Marie J, Devaux PF. Quantitative comparison between aminophospholipid translocase activity in human erythrocytes and in K562 cells. Biochim Biophys Acta. 1993 May 14;1148(1):85–90. [PubMed]
  • Crumpton MJ, Dedman JR. Protein terminology tangle. Nature. 1990 May 17;345(6272):212–212. [PubMed]
  • Daleke DL, Huestis WH. Incorporation and translocation of aminophospholipids in human erythrocytes. Biochemistry. 1985 Sep 24;24(20):5406–5416. [PubMed]
  • Daleke DL, Huestis WH. Erythrocyte morphology reflects the transbilayer distribution of incorporated phospholipids. J Cell Biol. 1989 Apr;108(4):1375–1385. [PMC free article] [PubMed]
  • de Kruijff B, van Zoelen EJ, van Deenen LL. Glycophorin facilitates the transbilayer movement of phosphatidylcholine in vesicles. Biochim Biophys Acta. 1978 Jun 2;509(3):537–542. [PubMed]
  • Demel RA, Jansen JW, van Dijck PW, van Deenen LL. The preferential interaction of cholesterol with different classes of phospholipids. Biochim Biophys Acta. 1977 Feb 14;465(1):1–10. [PubMed]
  • Deuticke B. Transformation and restoration of biconcave shape of human erythrocytes induced by amphiphilic agents and changes of ionic environment. Biochim Biophys Acta. 1968 Dec 10;163(4):494–500. [PubMed]
  • Deutsch JW, Kelly RB. Lipids of synaptic vesicles: relevance to the mechanism of membrane fusion. Biochemistry. 1981 Jan 20;20(2):378–385. [PubMed]
  • Devaux PF. Protein involvement in transmembrane lipid asymmetry. Annu Rev Biophys Biomol Struct. 1992;21:417–439. [PubMed]
  • Dominski J, Binaglia L, Dreyfus H, Massarelli R, Mersel M, Freysz L. A study on the topological distribution of phospholipids in microsomal membranes of chick brain using phospholipase C and trinitrobenzenesulfonic acid. Biochim Biophys Acta. 1983 Oct 12;734(2):257–266. [PubMed]
  • Drenthe EH, Klompmakers AA, Bonting SL, Daemen FJ. Transbilayer distribution of phospholipids in photoreceptor membrane studied with trinitrobenzenesulfonate alone and in combination with phospholipase D. Biochim Biophys Acta. 1980 Dec 2;603(1):130–141. [PubMed]
  • Drust DS, Creutz CE. Aggregation of chromaffin granules by calpactin at micromolar levels of calcium. Nature. 1988 Jan 7;331(6151):88–91. [PubMed]
  • Eastman SJ, Hope MJ, Cullis PR. Transbilayer transport of phosphatidic acid in response to transmembrane pH gradients. Biochemistry. 1991 Feb 19;30(7):1740–1745. [PubMed]
  • el Hage Chahine JM, Cribier S, Devaux PF. Phospholipid transmembrane domains and lateral diffusion in fibroblasts. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):447–451. [PMC free article] [PubMed]
  • Ellens H, Bentz J, Szoka FC. Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transition. Biochemistry. 1986 Jul 15;25(14):4141–4147. [PubMed]
  • Ellens H, Siegel DP, Alford D, Yeagle PL, Boni L, Lis LJ, Quinn PJ, Bentz J. Membrane fusion and inverted phases. Biochemistry. 1989 May 2;28(9):3692–3703. [PubMed]
  • Etemadi AH. Membrane asymmetry. A survey and critical appraisal of the methodology. II. Methods for assessing the unequal distribution of lipids. Biochim Biophys Acta. 1980 Dec 31;604(3):423–475. [PubMed]
  • Evans WH, Enrich C. Liver plasma membrane domains and endocytic trafficking. Biochem Soc Trans. 1989 Aug;17(4):619–622. [PubMed]
  • Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol. 1992 Apr 1;148(7):2207–2216. [PubMed]
  • Fisher KA. Analysis of membrane halves: cholesterol. Proc Natl Acad Sci U S A. 1976 Jan;73(1):173–177. [PMC free article] [PubMed]
  • Fontaine RN, Harris RA, Schroeder F. Aminophospholipid asymmetry in murine synaptosomal plasma membrane. J Neurochem. 1980 Feb;34(2):269–277. [PubMed]
  • Franck PF, Op den Kamp JA, Roelofsen B, van Deenen LL. Does diamide treatment of intact human erythrocytes cause a loss of phospholipid asymmetry? Biochim Biophys Acta. 1986 May 9;857(1):127–130. [PubMed]
  • Fujii T, Tamura A, Yamane T. Trans-bilayer movement of added phosphatidylcholine and lysophosphatidylcholine species with various acyl chain lengths in plasma membrane of intact human erythrocytes. J Biochem. 1985 Nov;98(5):1221–1227. [PubMed]
  • Ganong BR, Bell RM. Transmembrane movement of phosphatidylglycerol and diacylglycerol sulfhydryl analogues. Biochemistry. 1984 Oct 9;23(21):4977–4983. [PubMed]
  • Gascard P, Tran D, Sauvage M, Sulpice JC, Fukami K, Takenawa T, Claret M, Giraud F. Asymmetric distribution of phosphoinositides and phosphatidic acid in the human erythrocyte membrane. Biochim Biophys Acta. 1991 Oct 14;1069(1):27–36. [PubMed]
  • Gascard P, Sulpice JC, Tran D, Sauvage M, Claret M, Zachowski A, Devaux PF, Giraud F. Trans-bilayer distribution of phosphatidylinositol 4,5-bisphosphate and its role in the changes of lipid asymmetry in the human erythrocyte membrane. Biochem Soc Trans. 1993 May;21(2):253–257. [PubMed]
  • Geldwerth D, de Kermel A, Zachowski A, Guerbette F, Kader JC, Henry JP, Devaux PF. Use of spin-labeled and fluorescent lipids to study the activity of the phospholipid transfer protein from maize seedlings. Biochim Biophys Acta. 1991 Apr 3;1082(3):255–264. [PubMed]
  • Gilbert GE, Drinkwater D, Barter S, Clouse SB. Specificity of phosphatidylserine-containing membrane binding sites for factor VIII. Studies with model membranes supported by glass microspheres (lipospheres). J Biol Chem. 1992 Aug 5;267(22):15861–15868. [PubMed]
  • Gordesky SE, Marinetti GV, Segel GB. Differences in the reactivity of phospholipids with FDNB in normal RBC, sickle cells and RBC ghosts. Biochem Biophys Res Commun. 1972 Jun 9;47(5):1004–1009. [PubMed]
  • Gordesky SE, Marinetti GV, Love R. The reaction of chemical probes with the erythrocyte membrane. J Membr Biol. 1975;20(1-2):111–132. [PubMed]
  • Gudi SR, Kumar A, Bhakuni V, Gokhale SM, Gupta CM. Membrane skeleton-bilayer interaction is not the major determinant of membrane phospholipid asymmetry in human erythrocytes. Biochim Biophys Acta. 1990 Mar 30;1023(1):63–72. [PubMed]
  • Haest CW, Plasa G, Kamp D, Deuticke B. Spectrin as a stabilizer of the phospholipid asymmetry in the human erythrocyte membrane. Biochim Biophys Acta. 1978 May 4;509(1):21–32. [PubMed]
  • Hannun YA, Loomis CR, Bell RM. Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. J Biol Chem. 1986 Jun 5;261(16):7184–7190. [PubMed]
  • Harb JS, Comte J, Gautheron DC. Asymmetrical orientation of phospholipids and their interactions with marker enzymes in pig heart mitochondrial inner membrane. Arch Biochem Biophys. 1981 Apr 15;208(1):305–318. [PubMed]
  • Hebbel RP, Yamada O, Moldow CF, Jacob HS, White JG, Eaton JW. Abnormal adherence of sickle erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease. J Clin Invest. 1980 Jan;65(1):154–160. [PMC free article] [PubMed]
  • Herbette L, Blasie JK, Defoor P, Fleischer S, Bick RJ, Van Winkle WB, Tate CA, Entman ML. Phospholipid asymmetry in the isolated sarcoplasmic reticulum membrane. Arch Biochem Biophys. 1984 Oct;234(1):235–242. [PubMed]
  • Herrmann A, Devaux PF. Alteration of the aminophospholipid translocase activity during in vivo and artificial aging of human erythrocytes. Biochim Biophys Acta. 1990 Aug 10;1027(1):41–46. [PubMed]
  • Herrmann A, Zachowski A, Devaux PF. Protein-mediated phospholipid translocation in the endoplasmic reticulum with a low lipid specificity. Biochemistry. 1990 Feb 27;29(8):2023–2027. [PubMed]
  • Higgins JA, Evans WH. Transverse organization of phospholipids across the bilayer of plasma-membrane subfractions of rat hepatocytes. Biochem J. 1978 Aug 15;174(2):563–567. [PMC free article] [PubMed]
  • Hirata F, Axelrod J. Enzymatic synthesis and rapid translocation of phosphatidylcholine by two methyltransferases in erythrocyte membranes. Proc Natl Acad Sci U S A. 1978 May;75(5):2348–2352. [PMC free article] [PubMed]
  • Hoekstra D. Role of lipid phase separations and membrane hydration in phospholipid vesicle fusion. Biochemistry. 1982 Jun 8;21(12):2833–2840. [PubMed]
  • Hoekstra D. Topographical distribution of a membrane-inserted fluorescent phospholipid analogue during cell fusion. Exp Cell Res. 1983 Apr 1;144(2):482–488. [PubMed]
  • Hoover R, Rubin R, Wise G, Warren R. Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures. Blood. 1979 Oct;54(4):872–876. [PubMed]
  • Hope MJ, Cullis PR. Lipid asymmetry induced by transmembrane pH gradients in large unilamellar vesicles. J Biol Chem. 1987 Mar 25;262(9):4360–4366. [PubMed]
  • Hubbell WL. Transbilayer coupling mechanism for the formation of lipid asymmetry in biological membranes. Application to the photoreceptor disc membrane. Biophys J. 1990 Jan;57(1):99–108. [PMC free article] [PubMed]
  • Huber R, Römisch J, Paques EP. The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes. EMBO J. 1990 Dec;9(12):3867–3874. [PMC free article] [PubMed]
  • Hutson JL, Higgins JA. Asymmetric synthesis followed by transmembrane movement of phosphatidylethanolamine in rat liver endoplasmic reticulum. Biochim Biophys Acta. 1982 May 7;687(2):247–256. [PubMed]
  • Kawashima Y, Bell RM. Assembly of the endoplasmic reticulum phospholipid bilayer. Transporters for phosphatidylcholine and metabolites. J Biol Chem. 1987 Dec 5;262(34):16495–16502. [PubMed]
  • Killian JA, de Jong AM, Bijvelt J, Verkleij AJ, de Kruijff B. Induction of non-bilayer lipid structures by functional signal peptides. EMBO J. 1990 Mar;9(3):815–819. [PMC free article] [PubMed]
  • Kirby C, Green C. Transmembrane migration ('flip-flop') of cholesterol in erythrocyte membranes. Biochem J. 1977 Dec 15;168(3):575–577. [PMC free article] [PubMed]
  • Klee CB. Ca2+-dependent phospholipid- (and membrane-) binding proteins. Biochemistry. 1988 Sep 6;27(18):6645–6653. [PubMed]
  • Kornberg RD, McConnell HM. Inside-outside transitions of phospholipids in vesicle membranes. Biochemistry. 1971 Mar 30;10(7):1111–1120. [PubMed]
  • Krebs JJ, Hauser H, Carafoli E. Asymmetric distribution of phospholipids in the inner membrane of beef heart mitochondria. J Biol Chem. 1979 Jun 25;254(12):5308–5316. [PubMed]
  • Lange Y, Slayton JM. Interaction of cholesterol and lysophosphatidylcholine in determining red cell shape. J Lipid Res. 1982 Nov;23(8):1121–1127. [PubMed]
  • Lange Y, Dolde J, Steck TL. The rate of transmembrane movement of cholesterol in the human erythrocyte. J Biol Chem. 1981 Jun 10;256(11):5321–5323. [PubMed]
  • Lenard J, Rothman JE. Transbilayer distribution and movement of cholesterol and phospholipid in the membrane of influenza virus. Proc Natl Acad Sci U S A. 1976 Feb;73(2):391–395. [PMC free article] [PubMed]
  • LeNeveu DM, Rand RP. Measurement and modification of forces between lecithin bilayers. Biophys J. 1977 May;18(2):209–230. [PMC free article] [PubMed]
  • Lipka G, Op den Kamp JA, Hauser H. Lipid asymmetry in rabbit small intestinal brush border membrane as probed by an intrinsic phospholipid exchange protein. Biochemistry. 1991 Dec 24;30(51):11828–11836. [PubMed]
  • Lubin B, Chiu D, Bastacky J, Roelofsen B, Van Deenen LL. Abnormalities in membrane phospholipid organization in sickled erythrocytes. J Clin Invest. 1981 Jun;67(6):1643–1649. [PMC free article] [PubMed]
  • Maksymiw R, Sui SF, Gaub H, Sackmann E. Electrostatic coupling of spectrin dimers to phosphatidylserine containing lipid lamellae. Biochemistry. 1987 Jun 2;26(11):2983–2990. [PubMed]
  • Maneta-Peyret L, Freyburger G, Bessoule JJ, Cassagne C. Specific immunocytochemical visualization of phosphatidylserine. J Immunol Methods. 1989 Sep 1;122(2):155–159. [PubMed]
  • Marinetti GV, Senior AE, Love R, Broadhurst CI. Reaction of amino-phospholipids of the inner mitochondrial membrane with fluorodinitrobenzene and trinitrobenzenesulfonate. Chem Phys Lipids. 1976 Oct;17(2-3):353–362. [PubMed]
  • Martin OC, Pagano RE. Transbilayer movement of fluorescent analogs of phosphatidylserine and phosphatidylethanolamine at the plasma membrane of cultured cells. Evidence for a protein-mediated and ATP-dependent process(es). J Biol Chem. 1987 Apr 25;262(12):5890–5898. [PubMed]
  • McEvoy L, Williamson P, Schlegel RA. Membrane phospholipid asymmetry as a determinant of erythrocyte recognition by macrophages. Proc Natl Acad Sci U S A. 1986 May;83(10):3311–3315. [PMC free article] [PubMed]
  • Meers P, Daleke D, Hong K, Papahadjopoulos D. Interactions of annexins with membrane phospholipids. Biochemistry. 1991 Mar 19;30(11):2903–2908. [PubMed]
  • Middelkoop E, Lubin BH, Op den Kamp JA, Roelofsen B. Flip-flop rates of individual molecular species of phosphatidylcholine in the human red cell membrane. Biochim Biophys Acta. 1986 Mar 13;855(3):421–424. [PubMed]
  • Middelkoop E, Lubin BH, Bevers EM, Op den Kamp JA, Comfurius P, Chiu DT, Zwaal RF, van Deenen LL, Roelofsen B. Studies on sickled erythrocytes provide evidence that the asymmetric distribution of phosphatidylserine in the red cell membrane is maintained by both ATP-dependent translocation and interaction with membrane skeletal proteins. Biochim Biophys Acta. 1988 Jan 22;937(2):281–288. [PubMed]
  • Middelkoop E, Coppens A, Llanillo M, Van der Hoek EE, Slotboom AJ, Lubin BH, Op den Kamp JA, Van Deenen LL, Roelofsen B. Aminophospholipid translocase in the plasma membrane of Friend erythroleukemic cells can induce an asymmetric topology for phosphatidylserine but not for phosphatidylethanolamine. Biochim Biophys Acta. 1989 Jan 30;978(2):241–248. [PubMed]
  • Morris MB, Monteith G, Roufogalis BD. The inhibition of ATP-dependent shape change of human erythrocyte ghosts correlates with an inhibition of Mg(2+)-ATPase activity by fluoride and aluminofluoride complexes. J Cell Biochem. 1992 Apr;48(4):356–366. [PubMed]
  • Morrot G, Cribier S, Devaux PF, Geldwerth D, Davoust J, Bureau JF, Fellmann P, Herve P, Frilley B. Asymmetric lateral mobility of phospholipids in the human erythrocyte membrane. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6863–6867. [PMC free article] [PubMed]
  • Morrot G, Hervé P, Zachowski A, Fellmann P, Devaux PF. Aminophospholipid translocase of human erythrocytes: phospholipid substrate specificity and effect of cholesterol. Biochemistry. 1989 Apr 18;28(8):3456–3462. [PubMed]
  • Morrot G, Zachowski A, Devaux PF. Partial purification and characterization of the human erythrocyte Mg2(+)-ATPase. A candidate aminophospholipid translocase. FEBS Lett. 1990 Jun 18;266(1-2):29–32. [PubMed]
  • Myher JJ, Kuksis A, Pind S. Molecular species of glycerophospholipids and sphingomyelins of human erythrocytes: improved method of analysis. Lipids. 1989 May;24(5):396–407. [PubMed]
  • Newton AC, Koshland DE., Jr High cooperativity, specificity, and multiplicity in the protein kinase C-lipid interaction. J Biol Chem. 1989 Sep 5;264(25):14909–14915. [PubMed]
  • Newton AC, Koshland DE., Jr Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation. Biochemistry. 1990 Jul 17;29(28):6656–6661. [PubMed]
  • Nilsson OS, Dallner G. Transverse asymmetry of phospholipids in subcellular membranes of rat liver. Biochim Biophys Acta. 1977 Jan 21;464(2):453–458. [PubMed]
  • Nishizuka Y. Studies and perspectives of protein kinase C. Science. 1986 Jul 18;233(4761):305–312. [PubMed]
  • Olaisson H, Mårdh S, Arvidson G. Phospholipid organization in H,K-ATPase-containing membranes from pig gastric mucosa. J Biol Chem. 1985 Sep 15;260(20):11262–11267. [PubMed]
  • Op den Kamp JA. Lipid asymmetry in membranes. Annu Rev Biochem. 1979;48:47–71. [PubMed]
  • Orr JW, Newton AC. Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding. Biochemistry. 1992 May 19;31(19):4661–4667. [PubMed]
  • Orr JW, Newton AC. Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation. Biochemistry. 1992 May 19;31(19):4667–4673. [PubMed]
  • Pagano RE, Longmuir KJ. Phosphorylation, transbilayer movement, and facilitated intracellular transport of diacylglycerol are involved in the uptake of a fluorescent analog of phosphatidic acid by cultured fibroblasts. J Biol Chem. 1985 Feb 10;260(3):1909–1916. [PubMed]
  • Papahadjopoulos D, Vail WJ, Pangborn WA, Poste G. Studies on membrane fusion. II. Induction of fusion in pure phospholipid membranes by calcium ions and other divalent metals. Biochim Biophys Acta. 1976 Oct 5;448(2):265–283. [PubMed]
  • Papahadjopoulos D, Vail WJ, Newton C, Nir S, Jacobson K, Poste G, Lazo R. Studies on membrane fusion. III. The role of calcium-induced phase changes. Biochim Biophys Acta. 1977 Mar 17;465(3):579–598. [PubMed]
  • Patel VP, Fairbanks G. Relationship of major phosphorylation reactions and MgATPase activities to ATP-dependent shape change of human erythrocyte membranes. J Biol Chem. 1986 Mar 5;261(7):3170–3177. [PubMed]
  • Patzer EJ, Shaw JM, Moore NF, Thompson TE, Wagner RR. Transmembrane movement and distribution of cholesterol in the membrane of vesicular stomatitis virus. Biochemistry. 1978 Oct 3;17(20):4192–4200. [PubMed]
  • Pelletier X, Mersel M, Freysz L, Leray C. Topological distribution of aminophospholipid fatty acids in trout intestinal brush-border membrane. Biochim Biophys Acta. 1987 Aug 20;902(2):223–228. [PubMed]
  • Penniston JT. Endocytosis by erythrocyte ghosts; dependence upon ATP hydrolysis. Arch Biochem Biophys. 1972 Nov;153(1):410–412. [PubMed]
  • Penniston JT, Green DE. The conformational basis of energy transformations in membrane systems. IV. Energized states and pinocytosis in erythrocyte ghosts. Arch Biochem Biophys. 1968 Nov;128(2):339–350. [PubMed]
  • Perret B, Chap HJ, Douste-Blazy L. Asymmetric distribution of arachidonic acid in the plasma membrane of human platelets. A determination using purified phospholipases and a rapid method for membrane isolation. Biochim Biophys Acta. 1979 Oct 5;556(3):434–446. [PubMed]
  • Portis A, Newton C, Pangborn W, Papahadjopoulos D. Studies on the mechanism of membrane fusion: evidence for an intermembrane Ca2+-phospholipid complex, synergism with Mg2+, and inhibition by spectrin. Biochemistry. 1979 Mar 6;18(5):780–790. [PubMed]
  • Post JA, Langer GA, Op den Kamp JA, Verkleij AJ. Phospholipid asymmetry in cardiac sarcolemma. Analysis of intact cells and 'gas-dissected' membranes. Biochim Biophys Acta. 1988 Aug 18;943(2):256–266. [PubMed]
  • Poznansky M, Lange Y. Transbilayer movement of cholesterol in dipalmitoyllecithin-cholesterol vesicles. Nature. 1976 Feb 5;259(5542):420–421. [PubMed]
  • Raval PJ, Allan D. Phospholipid asymmetry in the membranes of intact human erythrocytes and in spectrin-free microvesicles derived from them. Biochim Biophys Acta. 1984 May 16;772(2):192–196. [PubMed]
  • Rawyler A, van der Schaft PH, Roelofsen B, Op den Kamp JA. Phospholipid localization in the plasma membrane of Friend erythroleukemic cells and mouse erythrocytes. Biochemistry. 1985 Mar 26;24(7):1777–1783. [PubMed]
  • Record M, El Tamer A, Chap H, Douste-Blazy L. Evidence for a highly asymmetric arrangement of ether- and diacyl-phospholipid subclasses in the plasma membrane of Krebs II ascites cells. Biochim Biophys Acta. 1984 Dec 19;778(3):449–456. [PubMed]
  • Redelmeier TE, Hope MJ, Cullis PR. On the mechanism of transbilayer transport of phosphatidylglycerol in response to transmembrane pH gradients. Biochemistry. 1990 Mar 27;29(12):3046–3053. [PubMed]
  • Renooij W, Van Golde LM, Zwaal RF, Van Deenen LL. Topological asymmetry of phospholipid metabolism in rat erythrocyte membranes. Evidence for flip-flop of lecithin. Eur J Biochem. 1976 Jan 2;61(1):53–58. [PubMed]
  • Rimon G, Meyerstein N, Henis YI. Lateral mobility of phospholipids in the external and internal leaflets of normal and hereditary spherocytic human erythrocytes. Biochim Biophys Acta. 1984 Sep 5;775(3):283–290. [PubMed]
  • Rosing J, Tans G, Govers-Riemslag JW, Zwaal RF, Hemker HC. The role of phospholipids and factor Va in the prothrombinase complex. J Biol Chem. 1980 Jan 10;255(1):274–283. [PubMed]
  • Rothman JE, Dawidowicz EA. Asymmetric exchange of vesicle phospholipids catalyzed by the phosphatidylcholine exhange protein. Measurement of inside--outside transitions. Biochemistry. 1975 Jul;14(13):2809–2816. [PubMed]
  • Rousselet A, Colbeau A, Vignais PM, Devaux PF. Study of the transverse diffusion of spin-labeled phospholipids in biological membranes. II. Inner mitochondrial membrane of rat liver: use of phosphatidylcholine exchange protein. Biochim Biophys Acta. 1976 Mar 19;426(3):372–384. [PubMed]
  • Rousselet A, Guthmann C, Matricon J, Bienvenue A, Devaux PF. Study of the transverse diffusion of spin labeled phospholipids in biological membranes. I. Human red bloods cells. Biochim Biophys Acta. 1976 Mar 19;426(3):357–371. [PubMed]
  • Sandra A, Pagano RE. Phospholipid asymmetry in LM cell plasma membrane derivatives: polar head group and acyl chain distributions. Biochemistry. 1978 Jan 24;17(2):332–338. [PubMed]
  • Schlegel RA, Prendergast TW, Williamson P. Membrane phospholipid asymmetry as a factor in erythrocyte-endothelial cell interactions. J Cell Physiol. 1985 May;123(2):215–218. [PubMed]
  • Schrier SL, Chiu DT, Yee M, Sizer K, Lubin B. Alteration of membrane phospholipid bilayer organization in human erythrocytes during drug-induced endocytosis. J Clin Invest. 1983 Nov;72(5):1698–1705. [PMC free article] [PubMed]
  • Schrier SL, Junga I, Ma L. Studies on the effect of vanadate on endocytosis and shape changes in human red blood cells and ghosts. Blood. 1986 Nov;68(5):1008–1014. [PubMed]
  • Schrier SL, Zachowski A, Devaux PF. Mechanisms of amphipath-induced stomatocytosis in human erythrocytes. Blood. 1992 Feb 1;79(3):782–786. [PubMed]
  • Schrier SL, Zachowski A, Hervé P, Kader JC, Devaux PF. Transmembrane redistribution of phospholipids of the human red cell membrane during hypotonic hemolysis. Biochim Biophys Acta. 1992 Mar 23;1105(1):170–176. [PubMed]
  • Schroeder F, Nemecz G, Wood WG, Joiner C, Morrot G, Ayraut-Jarrier M, Devaux PF. Transmembrane distribution of sterol in the human erythrocyte. Biochim Biophys Acta. 1991 Jul 22;1066(2):183–192. [PubMed]
  • Schroit AJ, Fidler IJ. Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide. Cancer Res. 1982 Jan;42(1):161–167. [PubMed]
  • Schroit AJ, Zwaal RF. Transbilayer movement of phospholipids in red cell and platelet membranes. Biochim Biophys Acta. 1991 Nov 13;1071(3):313–329. [PubMed]
  • Schroit AJ, Madsen JW, Tanaka Y. In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes. J Biol Chem. 1985 Apr 25;260(8):5131–5138. [PubMed]
  • Schroit AJ, Bloy C, Connor J, Cartron JP. Involvement of Rh blood group polypeptides in the maintenance of aminophospholipid asymmetry. Biochemistry. 1990 Nov 13;29(45):10303–10306. [PubMed]
  • Schwartz RS, Tanaka Y, Fidler IJ, Chiu DT, Lubin B, Schroit AJ. Increased adherence of sickled and phosphatidylserine-enriched human erythrocytes to cultured human peripheral blood monocytes. J Clin Invest. 1985 Jun;75(6):1965–1972. [PMC free article] [PubMed]
  • Seigneuret M, Devaux PF. ATP-dependent asymmetric distribution of spin-labeled phospholipids in the erythrocyte membrane: relation to shape changes. Proc Natl Acad Sci U S A. 1984 Jun;81(12):3751–3755. [PMC free article] [PubMed]
  • Seigneuret M, Zachowski A, Hermann A, Devaux PF. Asymmetric lipid fluidity in human erythrocyte membrane: new spin-label evidence. Biochemistry. 1984 Sep 11;23(19):4271–4275. [PubMed]
  • Sessions A, Horwitz AF. Differentiation-related differences in the plasma membrane phospholipid asymmetry of myogenic and fibrogenic cells. Biochim Biophys Acta. 1983 Feb 9;728(1):103–111. [PubMed]
  • Sheetz MP, Singer SJ. Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions. Proc Natl Acad Sci U S A. 1974 Nov;71(11):4457–4461. [PMC free article] [PubMed]
  • Shukla SD, Hanahan DJ. Membrane alterations in cellular aging: susceptibility of phospholipids in density (age)-separated human erythrocytes to phospholipase A2. Arch Biochem Biophys. 1982 Mar;214(1):335–341. [PubMed]
  • Shukla SD, Billah MM, Coleman R, Finean JB, Michell RH. Modulation of the organization of erythrocyte membrane phospholipids by cytoplasmic ATP. The susceptibility of isoionic human erythrocytes ghosts to attack by detergents and phospholipase C. Biochim Biophys Acta. 1978 May 4;509(1):48–57. [PubMed]
  • Siegel DP. Inverted micellar intermediates and the transitions between lamellar, cubic, and inverted hexagonal lipid phases. II. Implications for membrane-membrane interactions and membrane fusion. Biophys J. 1986 Jun;49(6):1171–1183. [PMC free article] [PubMed]
  • Siess W. Molecular mechanisms of platelet activation. Physiol Rev. 1989 Jan;69(1):58–178. [PubMed]
  • Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ. Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity. J Biol Chem. 1989 Oct 15;264(29):17049–17057. [PubMed]
  • Smith RJ, Green C. The rate of cholesterol 'flip-flop' in lipid bilayers and its relation to membrane sterol pools. FEBS Lett. 1974 May 15;42(1):108–111. [PubMed]
  • Sune A, Bette-Bobillo P, Bienvenüe A, Fellmann P, Devaux PF. Selective outside-inside translocation of aminophospholipids in human platelets. Biochemistry. 1987 Jun 2;26(11):2972–2978. [PubMed]
  • Sune A, Vidal M, Morin P, Sainte-Marie J, Bienvenue A. Evidence for bidirectional transverse diffusion of spin-labeled phospholipids in the plasma membrane of guinea pig blood cells. Biochim Biophys Acta. 1988 Dec 22;946(2):315–327. [PubMed]
  • Tanaka KI, Ohnishi S. Heterogeneity in the fluidity of intact erythrocyte membrane and its homogenization upon hemolysis. Biochim Biophys Acta. 1976 Mar 5;426(2):218–231. [PubMed]
  • Tanaka Y, Schroit AJ. Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells. Recognition by autologous macrophages. J Biol Chem. 1983 Sep 25;258(18):11335–11343. [PubMed]
  • Tilley L, Cribier S, Roelofsen B, Op den Kamp JA, van Deenen LL. ATP-dependent translocation of amino phospholipids across the human erythrocyte membrane. FEBS Lett. 1986 Jan 1;194(1):21–27. [PubMed]
  • Tilly RH, Senden JM, Comfurius P, Bevers EM, Zwaal RF. Increased aminophospholipid translocase activity in human platelets during secretion. Biochim Biophys Acta. 1990 Nov 2;1029(1):188–190. [PubMed]
  • Utsugi T, Schroit AJ, Connor J, Bucana CD, Fidler IJ. Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes. Cancer Res. 1991 Jun 1;51(11):3062–3066. [PubMed]
  • van Deenen LL. Topology and dynamics of phospholipids in membranes. FEBS Lett. 1981 Jan 12;123(1):3–15. [PubMed]
  • van den Besselaar AM, de Druijff B, van den Bosch H, van Deenen LL. Phosphatidylcholine mobility in liver microsomal membranes. Biochim Biophys Acta. 1978 Jul 4;510(2):242–255. [PubMed]
  • Van der Schaft PH, Beaumelle B, Vial H, Roelofsen B, Op den Kamp JA, Van Deenen LL. Phospholipid organization in monkey erythrocytes upon Plasmodium knowlesi infection. Biochim Biophys Acta. 1987 Jul 10;901(1):1–14. [PubMed]
  • van Dieijen G, Tans G, Rosing J, Hemker HC. The role of phospholipid and factor VIIIa in the activation of bovine factor X. J Biol Chem. 1981 Apr 10;256(7):3433–3442. [PubMed]
  • van Duijn G, Luiken J, Verkleij AJ, de Kruijff B. Relation between lipid polymorphism and transbilayer movement of lipids in rat liver microsomes. Biochim Biophys Acta. 1986 Dec 16;863(2):193–204. [PubMed]
  • van Meer G, Op den Kamp JA. Transbilayer movement of various phosphatidylcholine species in intact human erythrocytes. J Cell Biochem. 1982;19(2):193–204. [PubMed]
  • van Meer G, Gahmberg CG, Op den Kamp JA, van Deenen LL. Phospholipid distribution in human En(a-) red cell membranes which lack the major sialoglycoprotein, glycophorin A. FEBS Lett. 1981 Nov 30;135(1):53–55. [PubMed]
  • Venien C, Le Grimellec C. Phospholipid asymmetry in renal brush-border membranes. Biochim Biophys Acta. 1988 Jul 7;942(1):159–168. [PubMed]
  • Verhoven B, Schlegel RA, Williamson P. Rapid loss and restoration of lipid asymmetry by different pathways in resealed erythrocyte ghosts. Biochim Biophys Acta. 1992 Feb 17;1104(1):15–23. [PubMed]
  • Verkleij AJ, Zwaal RF, Roelofsen B, Comfurius P, Kastelijn D, van Deenen LL. The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy. Biochim Biophys Acta. 1973 Oct 11;323(2):178–193. [PubMed]
  • Williamson P, Mattocks K, Schlegel RA. Merocyanine 540, a fluorescent probe sensitive to lipid packing. Biochim Biophys Acta. 1983 Jul 27;732(2):387–393. [PubMed]
  • Williamson P, Algarin L, Bateman J, Choe HR, Schlegel RA. Phospholipid asymmetry in human erythrocyte ghosts. J Cell Physiol. 1985 May;123(2):209–214. [PubMed]
  • Williamson P, Kulick A, Zachowski A, Schlegel RA, Devaux PF. Ca2+ induces transbilayer redistribution of all major phospholipids in human erythrocytes. Biochemistry. 1992 Jul 14;31(27):6355–6360. [PubMed]
  • Yamada S, Ohnishi S. Erythrocyte membrane fluidity change induced by intracellular delivery of Ca2+. Nihon Ketsueki Gakkai Zasshi. 1983 Dec;46(7):1406–1413. [PubMed]
  • Zachowski A, Devaux PF. Transmembrane movements of lipids. Experientia. 1990 Jun 15;46(6):644–656. [PubMed]
  • Zachowski A, Gaudry-Talarmain YM. Phospholipid transverse diffusion in synaptosomes: evidence for the involvement of the aminophospholipid translocase. J Neurochem. 1990 Oct;55(4):1352–1356. [PubMed]
  • Zachowski A, Fellman P, Devaux PF. Absence of transbilayer diffusion of spin-labeled sphingomyelin on human erythrocytes. Comparison with the diffusion of several spin-labeled glycerophospholipids. Biochim Biophys Acta. 1985 May 28;815(3):510–514. [PubMed]
  • Zachowski A, Favre E, Cribier S, Hervé P, Devaux PF. Outside-inside translocation of aminophospholipids in the human erythrocyte membrane is mediated by a specific enzyme. Biochemistry. 1986 May 6;25(9):2585–2590. [PubMed]
  • Zachowski A, Herrmann A, Paraf A, Devaux PF. Phospholipid outside-inside translocation in lymphocyte plasma membranes is a protein-mediated phenomenon. Biochim Biophys Acta. 1987 Feb 12;897(1):197–200. [PubMed]
  • Zachowski A, Henry JP, Devaux PF. Control of transmembrane lipid asymmetry in chromaffin granules by an ATP-dependent protein. Nature. 1989 Jul 6;340(6228):75–76. [PubMed]
  • Zilversmit DB, Hughes ME. Extensive exchange of rat liver microsomal phospholipids. Biochim Biophys Acta. 1977 Aug 15;469(1):99–110. [PubMed]
  • Zwaal RF, Bevers EM, Comfurius P, Rosing J, Tilly RH, Verhallen PF. Loss of membrane phospholipid asymmetry during activation of blood platelets and sickled red cells; mechanisms and physiological significance. Mol Cell Biochem. 91(1-2):23–31. [PubMed]

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