• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of oenvmedOccupational and Environmental MedicineCurrent TOCInstructions for authors
Occup Environ Med. Sep 1994; 51(9): 589–592.
PMCID: PMC1128051

Work related symptoms, sensitisation, and estimated exposure in workers not previously exposed to laboratory rats.


Findings are presented from the initial cross sectional phase of a cohort study of employees exposed to laboratory rats. Of 366 eligible workers at four sites 323 (88%) were surveyed; symptoms assessed by self completed questionnaire and sensitisation measured by the response to skin prick tests were related to intensity of exposure both to total dust and to rat urinary aeroallergen. Among 238 workers, without previous occupational exposure to rats, work related symptoms, which started after first employment at the site were related to exposure intensity (expressed either in terms of dust or of aeroallergen) at the time of onset of symptoms. These relations were stronger in atopic subjects but were unrelated to smoking. Positive skin tests to rat urinary extract were also more frequent with increased exposure, a relation found in both atopic subjects and in smokers. There was a strong association between work related symptoms and specific sensitisation.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (795K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Meredith SK, Taylor VM, McDonald JC. Occupational respiratory disease in the United Kingdom 1989: a report to the British Thoracic Society and the Society of Occupational Medicine by the SWORD project group. Br J Ind Med. 1991 May;48(5):292–298. [PMC free article] [PubMed]
  • Kibby T, Powell G, Cromer J. Allergy to laboratory animals: a prospective and cross-sectional study. J Occup Med. 1989 Oct;31(10):842–846. [PubMed]
  • Venables KM, Tee RD, Hawkins ER, Gordon DJ, Wale CJ, Farrer NM, Lam TH, Baxter PJ, Newman Taylor AJ. Laboratory animal allergy in a pharmaceutical company. Br J Ind Med. 1988 Oct;45(10):660–666. [PMC free article] [PubMed]
  • Venables KM, Upton JL, Hawkins ER, Tee RD, Longbottom JL, Newman Taylor AJ. Smoking, atopy, and laboratory animal allergy. Br J Ind Med. 1988 Oct;45(10):667–671. [PMC free article] [PubMed]
  • Nieuwenhuijsen MJ, Gordon S, Tee RD, Venables KM, McDonald JC, Newman Taylor AJ. Exposure to dust and rat urinary aeroallergens in research establishments. Occup Environ Med. 1994 Sep;51(9):593–596. [PMC free article] [PubMed]
  • Gordon S, Tee RD, Lowson D, Wallace J, Newman Taylor AJ. Reduction of airborne allergenic urinary proteins from laboratory rats. Br J Ind Med. 1992 Jun;49(6):416–422. [PMC free article] [PubMed]
  • Slovak AJ, Hill RN. Laboratory animal allergy: a clinical survey of an exposed population. Br J Ind Med. 1981 Feb;38(1):38–41. [PMC free article] [PubMed]
  • Botham PA, Davies GE, Teasdale EL. Allergy to laboratory animals: a prospective study of its incidence and of the influence of atopy on its development. Br J Ind Med. 1987 Sep;44(9):627–632. [PMC free article] [PubMed]
  • Hunskaar S, Fosse RT. Allergy to laboratory mice and rats: a review of the pathophysiology, epidemiology and clinical aspects. Lab Anim. 1990 Oct;24(4):358–374. [PubMed]
  • Taylor AN, Longbottom JL, Pepys J. Respiratory allergy to urine proteins of rats and mice. Lancet. 1977 Oct 22;2(8043):847–849. [PubMed]
  • Bland SM, Levine MS, Wilson PD, Fox NL, Rivera JC. Occupational allergy to laboratory animals: an epidemiologic study. J Occup Med. 1986 Nov;28(11):1151–1157. [PubMed]

Articles from Occupational and Environmental Medicine are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Cited in Books
    Cited in Books
    PubMed Central articles cited in books
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...