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BMJ. 1999 October 23; 319(7217): 1110–1113.
PMCID: PMC1116903
Recent advances
Otolaryngology
Aurelia Richards, specialist registrar in otolaryngology and Michael Gleeson, professor of otolaryngology and skull base surgery
Department of Otolaryngology and Skull Base Surgery, Guy's Hospital, London SE1 9RT
Correspondence to: M Gleeson mgleeson/at/umds.ac.uk
Life is punctuated with problems arising from the ears, nose, and throat. Minor ailments like colds and pharyngitis incapacitate briefly but remind us how wonderful it is to be well. We take for granted the ability to hear, walk straight, smell, breathe freely, speak clearly, sing, and swallow our own saliva easily and without conscious effort. Life becomes exceptionally difficult when disease affects these basic functions. Recent advances in otolaryngology have gone some way to addressing a few of these problems, which affect thousands of patients every year and have the potential to destroy the quality of their lives for decades.
Methods
This review has been driven by changes in our clinical practice over the past five years. The chosen topics have been searched through Medline from January 1996 to March 1999 using the key words hearing loss, hearing aid, pharyngeal pouch, functional endoscopic sinus surgery, dacryocystorhinostomy, orbital decompression, and cerebrospinal fluid leak.
About 8.7 million people are deaf or hard of hearing in the United Kingdom. A third of the population has a significant hearing loss by the time they retire (fig (fig1).1Figure 1). Half of these people could be helped by a simple hearing aid, but despite free NHS aids less than a quarter possess them. More surprisingly, over 80% of octogenarians have conspicuous hearing losses yet only a quarter use hearing aids. Why should this be so? For some, the need to wear a visible appliance is unacceptable even in advanced age, while for others crudely amplified sound, the frustration of whistling from auditory feedback, and irritation caused by occlusion of the ear canal by a mould is more of a hindrance than a help.
Figure 1
Figure 1
Figure 1
Prevalence of hearing loss in United Kingdom, proportion of people with potentially treatable hearing loss, and percentage using hearing aids by age
For patients with moderate to severe sensorineural hearing loss a new implantable device became available in Britain last year.1,2 The Vibrant P (programmable) and HF (high frequency) Soundbridges (Symphonix)work by increasing the amplitude of natural ossicular vibration.3 They achieve this through a floating mass transducer attached to the long process of the incus (fig (fig2).2Figure 2). The transducer, a hermetically sealed titanium bobbin wrapped in gold wire, contains a magnet (the floating mass) that moves back and forth according to the frequency and amplitude of the sound signal. It is driven by an electronic processor unit, which is connected to it by a fine wire. The processor unit modulates an electrical signal delivered by a receiver implanted in the skull just behind the ear. The external component of the system is held on the side of the patient's head by a magnet and concealed behind the hairline. It contains a microphone, battery, and the electronics to convert sound energy into a signal that can be transmitted to the internal receiver. Because this device directly drives the ossicular chain, auditory feedback is eliminated. Furthermore, the ear canal is not occluded by a mould.
Recent advances
  • Despite free access to hearing aids in Britain, less than half of people who could benefit have them
  • New implantable hearing aids eliminate auditory feedback and give better performance at high frequencies
  • Endoscopic stapling diverticulotomy is a safe treatment for most symptomatic pharyngeal pouches and has reduced the length of hospital stay
  • Long term postoperative results for functional endoscopic sinus surgery show subjective improvement of symptoms in most patients
  • Endoscopes inserted through the nose have reduced morbidity and hospital stay for patients requiring orbital decompression, dacryocystorhinostomy, and closure of cerebrospinal fluid leaks
Figure 2
Figure 2
Figure 2
Vibrant Soundbridge. A floating mass transducer is attached to the long process of the incus and connected to an internal receiver implanted and recessed in the skull. The external audio processor is attached by a magnet to the overlying skin behind the (more ...)
Some patients are inherently unsuitable for such a device—for example, those with chronic middle ear disease. Early results with this new technology are encouraging but, like any other implanted device, several years must pass before a final verdict can be made on its robustness and long term effects on the middle and inner ear. Nevertheless, it is an exciting development for patients who are fit for surgery, conform to audiometric criteria, have realistic expectations of possible gain, and cannot use conventional aids. Totally implanted devices are being developed with microphones beneath the skin and transcutaneously rechargeable power sources.
New technology is also helping patients with neurofibromatosis type 2. This disease causes bilateral acoustic neuromas, which over time destroy hearing completely. Some neuromas remain small for many years; others grow inexorably and need to be removed. It is not uncommon for the only hearing ear to be the one with the larger tumour. Resection usually destroys hearing in that ear. Until recently, people deafened by neurofibromatosis type 2 had to rely on signing and vibrotactile aids for communication. However, a multichannel auditory brainstem implant has now been developed. The device is fitted at the time of tumour resection into the lateral recess of the fourth ventricle, where it stimulates the cochlear nucleus. The electrode array is connected to a receiver and stimulator unit, which is sited like a conventional cochlear implant in the temporoparietal region of the skull. A microphone, speech processor, and transmitter coil are worn externally.
Hearing results for the first 20 implanted patients were reported in March 1998.4 Most patients were able to use the temporal cues it provided to supplement and improve lip reading skills. Nearly all patients experienced non-auditory sensations, which could be reduced by adjustments to the pattern and geometry of electrode stimulation. Auditory perception was often accompanied by tingling in the ipsilateral head, torso, arm, or leg and sometimes by synchronous alteration of visual field stability. There were no serious or permanent complications, and most non-auditory symptoms diminished spontaneously over time. With training, the performance of some patients rivalled that of people with conventional cochlear implants, and a few were able to use a telephone.
Greater understanding of the mechanisms producing cochlear damage could make the workplace safer for 25-30 million Europeans exposed to potentially hazardous noise.5 Noise damages the organ of Corti by either mechanical disruption or metabolic overload. Although shattered hair cells are unlikely to return to normal function, pharmacological strategies are being devised that could counter or reverse some deleterious metabolic effects (box). Other promising avenues of research include sound conditioning6 and gene therapy to increase protective neurotropic factors and increase expression of heat shock proteins, which facilitate cellular repair.7
Mechanisms of metabolic overload causing cochlear damage
  • Excessive release of glutamate (the main excitatory neurotransmitter in the afferent cochlear pathway) damages primary auditory dendrites
  • Nitric oxide produced by excessive stimulation of N-methyl d-aspartate receptors (a subtype of glutamate receptors) in the spiral ganglion damages hair cells and supporting cells
  • Oxygen free radicals generated by hair cells become toxic to plasma membranes when converted to hydroxyl radicals in the stria vascularis
  • Low magnesium concentrations weaken hair cells by reducing intracellular calcium ion concentration
A pharyngeal pouch can cause progressive dysphagia, regurgitation of undigested food, weight loss, and nocturnal cough. Pouches tend to develop in later life, and many patients will have adapted their diet to cope with their disability. Some small but symptomatic pouches can be treated by cricopharyngeal myotomy. Until recently, most surgeons advocated resection of a large diverticulum together with cricopharyngeal myotomy. This is a difficult procedure. Leakage from the pharyngeal repair, fistula formation, spreading infection, recurrent laryngeal nerve palsy, late stenosis at the level of the pharyngeal closure, and recurrence have all been reported.8 Average length of hospital stay is 5-7 days.
Modifications to stapling guns have led to renewed interest in Dohlman's procedure. In this endoscopic technique, the bridge of tissue between the pouch and oesophagus was divided by diathermy or, more recently, a carbon dioxide laser. Despite encouraging results in published series,9 the technique has not gained popularity in the United Kingdom because of unacceptable rates of recurrence and postoperative neck infections. The introduction of linear cutting stapling guns that divide the partition between pouch and oesophagus while sealing the edges has overcome these problems.10
Experience with this method is now sufficient to suggest that it is safe. Patients can drink within six hours of surgery and take a light diet the following day.11 Nasogastric feeding is not required, and most patients can be discharged home on the second postoperative day with instructions to eat a soft diet for one week. In selected patients, this pro- cedure can be undertaken as a day case. Leaks are uncommon but will usually develop within 24 hours of surgery.
Over the past decade surgical management of rhinosinusitis has completely changed. Introduction of telescopes into routine outpatient practice and their use intraoperatively to guide and focus attention on the middle meatus and osteomeatal complex has caused a revolution in rhinology. The ability to see the site of disease within the nose and paranasal sinuses clearly has allowed surgeons to develop more meticulous and thorough techniques to remove diseased tissue and leave the nose functionally stable. In addition, these advances in optics have facilitated a more detailed assessment and understanding of postoperative results. In 1997 an international task force produced a series of guidelines to assist clinical management. From their deliberations, a uniform nomenclature and staging method was derived to provide the necessary foundation for research into treatment and patient outcomes.12
Enthusiasm for functional endoscopic sinus surgery, engendered by a plethora of reports of short term success, has been justified more recently by the publication of long term postoperative results which show a continued trend towards subjective improvement of symptoms in most patients.13 Although complications have been reported, they are no worse than with traditional techniques of sinus surgery.14 Detailed analysis of postoperative results has shown that scarring and adhesions in the region of the maxillary and frontal sinus ostia and middle turbinate are the main cause of symptomatic obstruction of the sinus outflow tract.1416 Strategies to minimise scarring and the formation of synechiae have been devised. These include meticulous surgical technique; partial resection of the middle turbinate; use of tissue glues, spacers, and stents for dressings; and regular postoperative endoscopic toilet. Without doubt, minimising trauma to tissues and preserving normal mucosa are of paramount importance. New instrumentation has been developed to achieve this. The microdebrider is an electrically powered endonasal suction tool which contains a small rotating blade capable of excising polyps, mucosa, and even bone. It has been shown to aid preservation of the mucosa and middle turbinate and decrease the incidence of synechiae.17
Two other complications experienced with functional endoscopic sinus surgery have spawned new management techniques. Firstly, cerebrospinal fluid leaks from defects in the anterior skull base have long been recognised as a possible complication of sinus surgery. They also complicate fractures of the cranial base and sometimes develop spontaneously. Leaks which failed to close spontaneously were managed by a craniotomy with intradural repair. Nowadays endonasal approaches are preferred.18,19 The defect in the cranial base is often identified by computed tomography. Exact localisation can be facilitated by injecting a small amount of fluorescein into the lumbar theca. This stains the cerebrospinal fluid a yellowish green, which can then be seen flowing from the site of the leak during surgical exploration. Pedicled or free mucosal grafts derived from the nasal cavity have been used to seal these defects, and closure is achieved in about 95%. More importantly, these results have been accomplished with minimal morbidity. Secondly, an endonasal approach has been developed using the holmium yttrium-aluminium-garnet laser as an alternative to dacryocystorhinostomy for the management of epiphora, mucocoeles, and acute dacryocystitis. The procedure can be performed under local anaesthesia as a day case.20 It avoids a facial scar, any disruption of the medial canthal ligament, and also hospital admission for general anaesthesia.
Finally, experience of endoscopic sinus surgery has increased the confidence of some surgeons to operate close to the optic nerve. They are now able to decompress the orbits and optic nerves for patients with severe exophthalmos secondary to Graves' disease.21 Decompression is achieved through a standard endoscopic sphenoethmoidectomy and generous middle meatal antrostomy. The technique avoids a facial scar and damage to the nasolacrimal system, infraorbital nerve, and frontonasal duct.
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