Risk of upper gastrointestinal bleeding among users of antidepressant compounds and the binding and selectivity characteristics of those compounds for the human serotonin transporter
 
DrugAdjusted Relative Risk* (95% CI)Geometric mean of equilibrium dissociation constant for serotonin transporter
KD ± SEM (nmol)
Selectivity for serotonin transporter over norepinephrine transporterSelectivity for serotonin transporter over dopamine transporter
Trazodone*8.6 (2.1 to 35.1)160 (20)5346
Paroxetine*4.3 (2.2 to 8.3)0.13 (0.01)3003700
Sertraline*3.9 (1.1 to 8.3)0.29 (0.01)140086
Fluoxetine*2.5 (1.4 to 4.7)0.81 (0.02)3004300
Clomipramine*2.1 (0.9 to 5.1)0.28 (0.01)1307800
Imipramine2.1 (0.7 to 6.2)1.40 (0.03)276100
Amitriptyline 1.9 (1.2 to 2.9)4.30 (0.12)8.1760
Lofepramine1.8 (0.8 to 4.0)70 (4)0.077260
Trimipramine1.2 (0.2 to 6.0)149 (6)1625
Mianserine1.1 (0.1 to 9.2)4000 (300)0.0180.24
Dothiepin1.0 (0.6 to 1.6)8.6 (0.4)5.3620
Nortriptyline0.3 (0.0 to 3.5)18 (1)0.2462
Fluvoxamine*Not available2.2 (0.2)5804100
VenlafaxineNot available8.9 (0.3)1201000
Chlorpheniramine†Not available15.2 (0.8)94.769.7
Diphenhydramine†Not available3800 (400)0.250.58

* Compounds classified as selective serotonin reuptake inhibitors by de Abajo et al.4
† H1 antihistamine compounds included for comparative purposes
  Equilibrium dissociation constants and selectivity data derived from those published by Tatsumi et al.7