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J Neurol Neurosurg Psychiatry. Jul 1995; 59(1): 71–76.
PMCID: PMC1073604

Multiple sclerosis in the north Cambridgeshire districts of East Anglia.


The Cambridgeshire multiple sclerosis register was established in 1989 and initially reported a prevalence of 130/10(5) population for south and east Cambridgeshire (south Cambs). This survey has now been extended to the northern county districts where there were 449 patients with multiple sclerosis in population of 378,959 on 1 July 1993 (118/10(5); 95% confidence interval (95% CI) 108-130). Four hundred and four had either definite or probable disease (107/10(5); 95% CI: 98-118). This matches the highest figures in the series of seven epidemiological surveys carried out in southern England over the past decade. Comparison with these and other studies indicates that no latitudinal gradient of disease is found in southern England despite spanning four degrees of latitude.

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  • Poskanzer DC, Prenney LB, Sheridan JL, Kondy JY. Multiple sclerosis in the Orkney and Shetland Islands. I: Epidemiology, clinical factors, and methodology. J Epidemiol Community Health. 1980 Dec;34(4):229–239. [PMC free article] [PubMed]
  • Shepherd DI, Downie AW. Prevalence of multiple sclerosis in north-east Scotland. Br Med J. 1978 Jul 29;2(6133):314–316. [PMC free article] [PubMed]
  • Shepherd DI, Downie AW. A further prevalence study of multiple sclerosis in north-east Scotland. J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):310–315. [PMC free article] [PubMed]
  • Downie AW, Phadke JG. The chief scientist reports ... multiple sclerosis in North East Scotland. Health Bull (Edinb) 1984 May;42(3):151–156. [PubMed]
  • Cook SD, Cromarty JI, Tapp W, Poskanzer D, Walker JD, Dowling PC. Declining incidence of multiple sclerosis in the Orkney Islands. Neurology. 1985 Apr;35(4):545–551. [PubMed]
  • Crawford PM, West CR, Chadwick DW, Shaw MD. Arteriovenous malformations of the brain: natural history in unoperated patients. J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):1–10. [PMC free article] [PubMed]
  • Robertson N, Compston A. Surveying multiple sclerosis in the United Kingdom. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):2–6. [PMC free article] [PubMed]
  • Lockyer MJ. Prevalence of multiple sclerosis in five rural Suffolk practices. BMJ. 1991 Aug 10;303(6798):347–348. [PMC free article] [PubMed]
  • Mumford CJ, Fraser MB, Wood NW, Compston DA. Multiple sclerosis in the Cambridge health district of east Anglia. J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):877–882. [PMC free article] [PubMed]
  • Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. [PubMed]
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444–1452. [PubMed]
  • Swingler RJ, Compston DA. The prevalence of multiple sclerosis in south east Wales. J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1520–1524. [PMC free article] [PubMed]
  • Huttunen J, Hömberg V. EMG responses in leg muscles to postural perturbations in Huntington's disease. J Neurol Neurosurg Psychiatry. 1990 Jan;53(1):55–62. [PMC free article] [PubMed]
  • Williams ES, McKeran RO. Prevalence of multiple sclerosis in a south London borough. Br Med J (Clin Res Ed) 1986 Jul 26;293(6541):237–239. [PMC free article] [PubMed]
  • Rice-Oxley M, Williams ES, Rees JE. A prevalence survey of multiple sclerosis in Sussex. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):27–30. [PMC free article] [PubMed]
  • Sharpe G, Price SE, Last A, Thompson RJ. Multiple sclerosis in island populations: prevalence in the Bailiwicks of Guernsey and Jersey. J Neurol Neurosurg Psychiatry. 1995 Jan;58(1):22–26. [PMC free article] [PubMed]
  • Confavreux C, Compston DA, Hommes OR, McDonald WI, Thompson AJ. EDMUS, a European database for multiple sclerosis. J Neurol Neurosurg Psychiatry. 1992 Aug;55(8):671–676. [PMC free article] [PubMed]
  • Elian M, Nightingale S, Dean G. Multiple sclerosis among United Kingdom-born children of immigrants from the Indian subcontinent, Africa and the West Indies. J Neurol Neurosurg Psychiatry. 1990 Oct;53(10):906–911. [PMC free article] [PubMed]
  • Patchell RA, White CL, 3rd, Clark AW, Beschorner WE, Santos GW. Neurologic complications of bone marrow transplantation. Neurology. 1985 Mar;35(3):300–306. [PubMed]
  • Elian M, Dean G. Multiple sclerosis among the United Kingdom-born children of immigrants from the West Indies. J Neurol Neurosurg Psychiatry. 1987 Mar;50(3):327–332. [PMC free article] [PubMed]
  • Dean G. Annual incidence, prevalence, and mortality of multiple sclerosis in white South-African-born and in white immigrants to South Africa. Br Med J. 1967 Jun 17;2(5554):724–730. [PMC free article] [PubMed]
  • Skegg DC, Corwin PA, Craven RS, Malloch JA, Pollock M. Occurrence of multiple sclerosis in the north and south of New Zealand. J Neurol Neurosurg Psychiatry. 1987 Feb;50(2):134–139. [PMC free article] [PubMed]
  • Phadke JG, Downie AW. Epidemiology of multiple sclerosis in the north-east (Grampian region) of Scotland--an update. J Epidemiol Community Health. 1987 Mar;41(1):5–13. [PMC free article] [PubMed]

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