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J Neurol Neurosurg Psychiatry. May 1995; 58(5): 577–581.
PMCID: PMC1073488

Prevalence of multiple sclerosis in the region of Osona, Catalonia, northern Spain.


To ascertain the prevalence of multiple sclerosis in the region of Osona in Catalonia, northern Spain, an intensive study was undertaken in a small population of 72,000 people over a period of five years, using many sources of information. Patients were classified according to the Poser criteria. Most of the patients presented with mild symptoms only and many had not seen a neurologist or attended a large hospital. The prevalence of definite and probable multiple sclerosis was 58 per 100,000. This is nine to 10 times higher than had been found previously in Catalonia and is a similar prevalence to that found in southern Spain, in Sicily, and in Greek speaking Cyprus.

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Selected References

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  • Miró J, Rebollo M, Combarros O, Polo JM, Leno C, Berciano J. Esclerosis múltiple en Cantabria. Estudio retrospectivo de 30 casos. Rev Clin Esp. 1984 Nov 15;175(3-4):153–156. [PubMed]
  • Sosa Enríguez M, Betancor León P, Rosas C, Navarro MC. La esclerosis múltiple en la provincia de Las Palmas. Arch Neurobiol (Madr) 1983 May-Jun;46(3):161–166. [PubMed]
  • Barduzal Angles S, Oliveros Juste A, Manubens Bertrán JM, Morales Asín F. Esclerosis múltiple: estudio epidemiológico retrospectivo en Aragón (1975-1985). Neurologia. 1987 May-Jun;2(3):97–100. [PubMed]
  • Fernández O, Izquierdo G, Campos VM, Pastor M. Epidemiología de la esclerosis múltiple en la provincia de Málaga (España). Un estudio de prevalencia. Neurologia. 1986 Jan-Feb;1(1):3–5. [PubMed]
  • García-Ruiz PJ, García-Urra D, Guerrero-Sola A, Varela de Seijas Slocker E. Triple asociación: polimiositis-artritis reumatoidea-neoplasia. Neurologia. 1988 Jan-Feb;3(1):35–36. [PubMed]
  • Matias-Guiu J, Bolumar F, Martin R, Insa R, Casquero P, Moltó JM, Calatayud E, Aranaz J. Multiple sclerosis in Spain: an epidemiological study of the Alcoy health region, Valencia. Acta Neurol Scand. 1990 Jun;81(6):479–483. [PubMed]
  • Antón Aranda E, Martínez-Lage JM, Maraví Petri E, Gállego Culleré J, de Castro P, Villanueva Eusa JA. Epidemiología y aspectos clinicoevolutivos de la esclerosis múltiple en Navarra. Neurologia. 1991 May;6(5):160–169. [PubMed]
  • Garcia JR, Rodriguez S, Sosa Henriquez M, Batista E, Corujo E, Font de Mora Turon A, Hernandez Hernandez D, Betancor Leon P. Prevalence of multiple sclerosis in Lanzarote (Canary Islands) Neurology. 1989 Feb;39(2 Pt 1):265–267. [PubMed]
  • Uría DF, Virgala P, Alonso P, Crespo JR, Calatayud T, Arribas JM. Epidemiología de la esclerosis múltiple en Asturias. Neurologia. 1991 Feb;6(2):41–45. [PubMed]
  • Navarro X. Geographical distribution of multiple sclerosis mortality in Spain. Acta Neurol Scand. 1987 Oct;76(4):306–309. [PubMed]
  • Dean G, Grimaldi G, Kelly R, Karhausen L. Multiple sclerosis in southern Europe. I: Prevalence in Sicily in 1975. J Epidemiol Community Health. 1979 Jun;33(2):107–110. [PMC free article] [PubMed]
  • Savettieri G, Daricello B, Giordano D, Karhausen L, Dean G. The prevalence of multiple sclerosis in Sicily. I: Monreale city. J Epidemiol Community Health. 1981 Jun;35(2):114–117. [PMC free article] [PubMed]
  • Savettieri G, Elian M, Giordano D, Grimaldi G, Ventura A, Dean G. A further study on the prevalence of multiple sclerosis in Sicily: Caltanissetta city. Acta Neurol Scand. 1986 Jan;73(1):71–75. [PubMed]
  • Morganti G, Naccarato S, Elian M, Ferrari P, Kelly R, Karhausen L, Dean G. Multiple sclerosis in the Republic of San Marino. J Epidemiol Community Health. 1984 Mar;38(1):23–28. [PMC free article] [PubMed]
  • Middleton LT, Dean G. Multiple sclerosis in Cyprus. J Neurol Sci. 1991 May;103(1):29–36. [PubMed]
  • Bertranpetit J, Cavalli-Sforza LL. A genetic reconstruction of the history of the population of the Iberian Peninsula. Ann Hum Genet. 1991 Jan;55(Pt 1):51–67. [PubMed]
  • Rosati G, Aiello I, Pirastru MI, Mannu L, Demontis G, Becciu S, Sau G, Zoccheddu A. Sardinia, a high-risk area for multiple sclerosis: a prevalence and incidence study in the district of Alghero. Ann Neurol. 1987 Feb;21(2):190–194. [PubMed]
  • Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. [PubMed]
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444–1452. [PubMed]
  • Fernández O, Luque G, San Román C, Bravo M, Dean G. The prevalence of multiple sclerosis in the Sanitary District of Vélez-Málaga, southern Spain. Neurology. 1994 Mar;44(3 Pt 1):425–429. [PubMed]
  • Elian M, Dean G. The changing mortality from motor neurone disease and multiple sclerosis in England and Wales and the Republic of Ireland. Neuroepidemiology. 1992;11(4-6):236–243. [PubMed]

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