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J Neurol Neurosurg Psychiatry. 1995 Jan; 58(1): 27–30.
PMCID: PMC1073264

A prevalence survey of multiple sclerosis in Sussex.


A first survey of the Brighton and Mid-Downs health districts in Sussex showed a prevalence of multiple sclerosis of 111 per 100,000 (95% confidence interval (95% CI) 103-120) in a population of 596,594 on prevalence day, 1 July 1991. Cases were notified by multiple sources and to maximise case notification patients were not contacted. Cases were classified by hospital and family practitioner notes. The Poser criteria were used for classification. These criteria are precise and exclude cases of isolated spinal cord syndrome. The Allison and Millar criteria used in the surveys in Scotland may lack specificity and it is concluded that the high prevalence of multiple sclerosis in Scotland needs to be reassessed with the more precise criteria. Until this is done, the latitude effect within the United Kingdom remains not proved.

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Selected References

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  • SUTHERLAND JM. Observations on the prevalence of multiple sclerosis in Northern Scotland. Brain. 1956 Dec;79(4):635–654. [PubMed]
  • Shepherd DI, Downie AW. Prevalence of multiple sclerosis in north-east Scotland. Br Med J. 1978 Jul 29;2(6133):314–316. [PMC free article] [PubMed]
  • Shepherd DI, Downie AW. A further prevalence study of multiple sclerosis in north-east Scotland. J Neurol Neurosurg Psychiatry. 1980 Apr;43(4):310–315. [PMC free article] [PubMed]
  • Downie AW, Phadke JG. The chief scientist reports ... multiple sclerosis in North East Scotland. Health Bull (Edinb) 1984 May;42(3):151–156. [PubMed]
  • Phadke JG, Downie AW. Epidemiology of multiple sclerosis in the north-east (Grampian region) of Scotland--an update. J Epidemiol Community Health. 1987 Mar;41(1):5–13. [PMC free article] [PubMed]
  • HARGREAVES ER. Epidemiological studies in Cornwall. Proc R Soc Med. 1961 Mar;54:209–216. [PMC free article] [PubMed]
  • Williams ES, McKeran RO. Prevalence of multiple sclerosis in a south London borough. Br Med J (Clin Res Ed) 1986 Jul 26;293(6541):237–239. [PMC free article] [PubMed]
  • Swingler RJ, Compston DA. The prevalence of multiple sclerosis in south east Wales. J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1520–1524. [PMC free article] [PubMed]
  • Roberts MH, Martin JP, McLellan DL, McIntosh-Michaelis SA, Spackman AJ. The prevalence of multiple sclerosis in the Southampton and South West Hampshire Health Authority. J Neurol Neurosurg Psychiatry. 1991 Jan;54(1):55–59. [PMC free article] [PubMed]
  • Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. [PubMed]
  • Mumford CJ, Fraser MB, Wood NW, Compston DA. Multiple sclerosis in the Cambridge health district of east Anglia. J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):877–882. [PMC free article] [PubMed]
  • Hennessy A, Swingler RJ, Compston DA. The incidence and mortality of multiple sclerosis in south east Wales. J Neurol Neurosurg Psychiatry. 1989 Sep;52(9):1085–1089. [PMC free article] [PubMed]
  • Fog M, Hyllested K. Prevalence of disseminated sclerosis in the Faroes, the Orkneys and Shetland. Acta Neurol Scand. 1966;42(Suppl):9–11. [PubMed]
  • Poskanzer DC, Prenney LB, Sheridan JL, Kondy JY. Multiple sclerosis in the Orkney and Shetland Islands. I: Epidemiology, clinical factors, and methodology. J Epidemiol Community Health. 1980 Dec;34(4):229–239. [PMC free article] [PubMed]
  • Francis DA, Batchelor JR, McDonald WI, Hing SN, Dodi IA, Fielder AH, Hern JE, Downie AW. Multiple sclerosis in north-east Scotland. An association with HLA-DQw1. Brain. 1987 Feb;110(Pt 1):181–196. [PubMed]

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