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J Neurol Neurosurg Psychiatry. Jan 1995; 58(1): 22–26.
PMCID: PMC1073263

Multiple sclerosis in island populations: prevalence in the Bailiwicks of Guernsey and Jersey.

Abstract

The aim of this study was to establish for the first time the prevalence of multiple sclerosis in the Bailiwicks of Guernsey and Jersey, as representing the most southerly part of the British Isles. All patients with multiple sclerosis in the Channel Islands resident on prevalence day were identified by contacting all medical practices, Multiple Sclerosis, and Action Research for Multiple Sclerosis societies by letter and visits. The crude overall prevalence rates were 113/100,000 (95% confidence interval (95% CI) 90.3-135.7) and 86.7/100,000 (95% CI 63.3-110.0) for the Bailiwicks of Jersey and Guernsey respectively. When standardised to the age and sex structure of a previously reported Northern Ireland population the standardised prevalence ratios were 120.2/100,000 (95% CI 96.0-144.3) for Jersey and 95.6/100,000 (95% CI 69.9-121.3) for the Bailiwick of Guernsey. When compared with recent studies in the northern United Kingdom the prevalence rates for multiple sclerosis in the Channel Islands lend some support to the proposed latitudinal gradient in the British Isles although the standardised prevalence ratio in the Bailiwick of Jersey is similar to those found in recent studies of southern Britain. The standardised prevalence rates of probable and definite multiple sclerosis for the male populations were 37.3/100,000 (95% CI 17.9-56.7) for the Bailiwick of Guernsey and 45.5/100,000 (95% CI 26.3-64.7) for the Bailiwick of Jersey whereas the standardised prevalence rates for the female populations were 97.5/100,000 (95% CI 73.9-143.5) and 139.5/100,000 (95% CI 112.6-181.2) respectively. Thus there is a striking and unexplained 43% higher prevalence of probable and definite multiple sclerosis in the female population of Jersey compared with that of the Bailiwick of Guernsey. This seems to be due to an unusually low prevalence of the disease among the female population of the Bailiwick of Guernsey compared with that of the United Kingdom mainland.

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Selected References

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  • Compston DA. The dissemination of multiple sclerosis. The Langdon-Brown lecture 1989. J R Coll Physicians Lond. 1990 Jul;24(3):207–218. [PubMed]
  • Poskanzer DC, Prenney LB, Sheridan JL, Kondy JY. Multiple sclerosis in the Orkney and Shetland Islands. I: Epidemiology, clinical factors, and methodology. J Epidemiol Community Health. 1980 Dec;34(4):229–239. [PMC free article] [PubMed]
  • Rosati G, Aiello I, Pirastru MI, Mannu L, Demontis G, Becciu S, Sau G, Zoccheddu A. Sardinia, a high-risk area for multiple sclerosis: a prevalence and incidence study in the district of Alghero. Ann Neurol. 1987 Feb;21(2):190–194. [PubMed]
  • Dean G, Grimaldi G, Kelly R, Karhausen L. Multiple sclerosis in southern Europe. I: Prevalence in Sicily in 1975. J Epidemiol Community Health. 1979 Jun;33(2):107–110. [PMC free article] [PubMed]
  • Poskanzer DC, Walker AM, Prenney LB, Sheridan JL. The etiology of multiple sclerosis: temporal-spatial clustering indicating two environmental exposures before onset. Neurology. 1981 Jun;31(6):708–713. [PubMed]
  • Sheremata WA, Poskanzer DC, Withum DG, MacLeod CL, Whiteside ME. Unusual occurrence on a tropical island of multiple sclerosis. Lancet. 1985 Sep 14;2(8455):618–618. [PubMed]
  • Kurtzke JF, Hyllested K. Multiple sclerosis in the Faroe Islands. III. An alternative assessment of the three epidemics. Acta Neurol Scand. 1987 Nov;76(5):317–339. [PubMed]
  • Martin JR. Troop-related multiple sclerosis outbreak in the Orkneys? J Epidemiol Community Health. 1987 Jun;41(2):183–184. [PMC free article] [PubMed]
  • Kurtzke JF, Gudmundsson KR, Bergmann S. Multiple sclerosis in Iceland: 1. Evidence of a postwar epidemic. Neurology. 1982 Feb;32(2):143–150. [PubMed]
  • Williams ES, McKeran RO. Prevalence of multiple sclerosis in a south London borough. Br Med J (Clin Res Ed) 1986 Jul 26;293(6541):237–239. [PMC free article] [PubMed]
  • Lockyer MJ. Prevalence of multiple sclerosis in five rural Suffolk practices. BMJ. 1991 Aug 10;303(6798):347–348. [PMC free article] [PubMed]
  • Roberts MH, Martin JP, McLellan DL, McIntosh-Michaelis SA, Spackman AJ. The prevalence of multiple sclerosis in the Southampton and South West Hampshire Health Authority. J Neurol Neurosurg Psychiatry. 1991 Jan;54(1):55–59. [PMC free article] [PubMed]
  • Swingler RJ, Compston DA. The prevalence of multiple sclerosis in south east Wales. J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1520–1524. [PMC free article] [PubMed]
  • Mumford CJ, Fraser MB, Wood NW, Compston DA. Multiple sclerosis in the Cambridge health district of east Anglia. J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):877–882. [PMC free article] [PubMed]
  • Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. [PubMed]
  • Phadke JG, Downie AW. Epidemiology of multiple sclerosis in the north-east (Grampian region) of Scotland--an update. J Epidemiol Community Health. 1987 Mar;41(1):5–13. [PMC free article] [PubMed]

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