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J Clin Invest. Sep 1958; 37(9): 1236–1256.
PMCID: PMC1062793

Interrelations Between Serum Sodium Concentration, Serum Osmolarity and Total Exchangeable Sodium, Total Exchangeable Potassium and Total Body Water1

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Selected References

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  • MOORE FD, EDELMAN IS, OLNEY JM, JAMES AH, BROOKS L, WILSON GM. Body sodium and potassium. III. Interrelated trends in alimentary, renal and cardiovascular disease; lack of correlation between body stores and plasma concentration. Metabolism. 1954 Jul;3(4):334–350. [PubMed]
  • WARNER GF, SWEET NJ, DOBSON EL. Sodium space and body sodium content, exchangeable with sodium24, in normal individuals and patients with ascites. Circ Res. 1953 Nov;1(6):486–490. [PubMed]
  • WELT LG. Edema and hyponatremia. AMA Arch Intern Med. 1952 Jun;89(6):931–942. [PubMed]
  • WILSON GM, EDELMAN IS, BROOKS L, MYRDEN JA, HARKEN DE, MOORE FD. Metabolic changes associated with mitral valvuloplasty. Circulation. 1954 Feb;9(2):199–219. [PubMed]
  • PETERS JP, WELT LG, SIMS EAH, ORLOFF J, NEEDHAM J. A salt-wasting syndrome associated with cerebral disease. Trans Assoc Am Physicians. 1950;63:57–64. [PubMed]
  • NICHOLS G, Jr, NICHOLS N. Changes in tissue composition during acute sodium depletion. Am J Physiol. 1956 Sep;186(3):383–392. [PubMed]
  • EDELMAN IS. The pathogenesis of hyponatremia: physiologic and therapeutic implications. Metabolism. 1956 Jul;5(4):500–507. [PubMed]
  • WOLF AV, McDOWELL ME. Apparent and osmotic volumes of distribution of sodium, chloride, sulfate and urea. Am J Physiol. 1954 Feb;176(2):207–212. [PubMed]
  • GABUZDA GJ, Jr, TRAEGER HS, DAVIDSON CS. Hepatic cirrhosis: effect of sodium chloride administration and restriction and of abdominal paracentesis on electrolyte and water balance. J Clin Invest. 1954 May;33(5):780–789. [PMC free article] [PubMed]
  • DEMING Q, GERBODE F. Observations on sodium balance in patients undergoing mitral valvotomy. Surg Forum. 1953 Oct;4:18–22. [PubMed]
  • LARAGH JH. The effect of potassium chloride on hyponatremia. J Clin Invest. 1954 May;33(5):807–818. [PMC free article] [PubMed]
  • STOCK RJ, MUDGE GH, NURNBERG MJ. Congestive heart failure; variations in electrolyte metabolism with salt restriction and mercurial diuretics. Circulation. 1951 Jul;4(1):54–60. [PubMed]
  • SQUIRES RD, SINGER RB, MOFFITT GR, Jr, ELKINTON JR. The distribution of body fluids in congestive heart failure. II. Abnormalities in serum electrolyte concentration and in acid-base equilibrium. Circulation. 1951 Nov;4(5):697–705. [PubMed]
  • EDELMAN IS, JAMES AH, BADEN H, MOORE FD. Electrolyte composition of bone and the penetration of radiosodium and deuterium oxide into dog and human bone. J Clin Invest. 1954 Feb;33(2):122–131. [PMC free article] [PubMed]
  • EDELMAN IS, SWEET NJ. Gastrointestinal water and electrolytes. I. The equilibration of radiosodium in gastrointestinal contents and the proportion of exchangeable sodium (Nae) in the gastrointestinal tract. J Clin Invest. 1956 May;35(5):502–511. [PMC free article] [PubMed]
  • BERGSTROM WH, WALLACE WM. Bone as a sodium and potassium reservoir. J Clin Invest. 1954 Jun;33(6):867–873. [PMC free article] [PubMed]
  • BIRKENFELD LW, LEIBMAN J, O'MEARA MP, EDELMAN IS. Total exchangeable sodium, total exchangeable potassium, and total body water in edematous patients with cirrhosis of the liver and congestive heart failure. J Clin Invest. 1958 May;37(5):687–698. [PMC free article] [PubMed]
  • O'MEARA MP, BIRKENFELD LW, GOTCH FA, EDELMAN IS. The equilibration of radiosodium (Na24), radiopotassium (K42), and deuterium oxide (D2O) in hydropic human subjects. J Clin Invest. 1957 Jun;36(6 Pt 1):784–792. [PMC free article] [PubMed]
  • SANDERSON PH. Potentiometric determination of chloride in biological fluids. Biochem J. 1952 Nov;52(3):502–505. [PMC free article] [PubMed]
  • CORSA L, Jr, OLNEY JM, Jr, STEENBURG RW, BALL MR, MOORE FD. The measurement of exchangeable potassium in man by isotope dilution. J Clin Invest. 1950 Oct;29(10):1280–1295. [PMC free article] [PubMed]
  • EDELMAN IS, JAMES AH, BROOKS L, MOORE FD. Body sodium and potassium. IV. The normal total exchangeable sodium; its measurement and magnitude. Metabolism. 1954 Nov;3(6):530–538. [PubMed]
  • SCHLOERB PR, FRIIS-HANSEN BJ, EDELMAN IS, SOLOMON AK, MOORE FD. The measurement of total body water in the human subject by deuterium oxide dilution; with a consideration of the dynamics of deuterium distribution. J Clin Invest. 1950 Oct;29(10):1296–1310. [PMC free article] [PubMed]
  • ALBRINK MJ, HALD PM, MAN EB, PETERS JP. The displacement of serum water by the lipids of hyperlipemic serum; a new method for the rapid determination of serum water. J Clin Invest. 1955 Oct;34(10):1483–1488. [PMC free article] [PubMed]
  • SCHLOERB PR, FRIIS-HANSEN BJ, EDELMAN IS, SHELDON DB, MOORE FD. The measurement of deuterium oxide in body fluids by the falling drop method. J Lab Clin Med. 1951 Apr;37(4):653–662. [PubMed]
  • JAMES AH, BROOKS L, EDELMAN IS, OLNEY JM, MOORE FD. Body sodium and potassium. I. Simultaneous measurement of exchangeable sodium and potassium in man by isotope dilution. Metabolism. 1954 Jul;3(4):313–323. [PubMed]
  • TALSO PJ, SPAFFORD N, FERENZI G, JACKSON HO. Paradoxical hyponatremia associated with congestive heart failure and with cirrhosis of the liver. Metabolism. 1956 Jan;5(1):58–69. [PubMed]
  • LEAF A, CHATILLON JY, WRONG O, TUTTLE EP., Jr The mechanism of the osmotic adjustment of body cells as determined in vivo by the volume of distribution of a large water load. J Clin Invest. 1954 Sep;33(9):1261–1268. [PMC free article] [PubMed]
  • WYNN V. The osmotic behaviour of the body cells in man; significance of changes of plasma-electrolyte levels in body-fluid disorders. Lancet. 1957 Dec 14;273(7007):1212–1218. [PubMed]
  • WOLF AV, McDOWELL ME. Sodium concentration deficit; nomogram for replacement. J Appl Physiol. 1953 Dec;6(6):355–357. [PubMed]
  • WOLF AV. Relative tonicity of cellular and extracellular fluid in vivo. J Appl Physiol. 1956 May;8(6):674–676. [PubMed]
  • BERGSTROM WH. The participation of bone in total body sodium metabolism in the rat. J Clin Invest. 1955 Jul;34(7 Pt 1):997–1004. [PMC free article] [PubMed]
  • McDOWELL ME, WOLF AV, STEER A. Osmotic volumes of distribution; idiogenic changes in osmotic pressure associated with administration of hypertonic solutions. Am J Physiol. 1955 Mar;180(3):545–558. [PubMed]
  • DEYRUP I. A study of the fluid uptake of rat kidney slices in vitro. J Gen Physiol. 1953 Jul;36(6):739–749. [PMC free article] [PubMed]
  • CONWAY EJ, MCCORMACK JI. The total intracellular concentration of mammalian tissues compared with that of the extra-cellular fluid. J Physiol. 1953 Apr 28;120(1-2):1–14. [PMC free article] [PubMed]
  • NADELL J, SWEET NJ, EDELMAN IS. Gastrointestinal water and electrolytes. II. The equilibration of radiopotassium in gastrointestinal contents and the proportion of exchangeable potassium (Ke) in the gastrointestinal tract. J Clin Invest. 1956 May;35(5):512–521. [PMC free article] [PubMed]
  • GOTCH F, NADELL J, EDELMAN IS. Gastrointestinal water and electroyltes. IV. The equilibration of deuterium oxide (D2O) in gastrointestinal contents and the proportion of total body water (T.B.W.) in the gastrointestinal tract. J Clin Invest. 1957 Feb;36(2):289–296. [PMC free article] [PubMed]

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