|
|
Arch Dis Child Fetal Neonatal Ed. 1994 May; 70(3): F192–F194. | PMCID: PMC1061039 |
Umbilical cord blood erythroblast count as an index of intrauterine hypoxia. B Thilaganathan, S Athanasiou, S Ozmen, S Creighton, N R Watson, and K H Nicolaides Harris Birthright Research Centre for Fetal Medicine, King's College School of Medicine, London. Abstract The relation of umbilical cord blood arterial pH, Apgar score, leucocyte count, and erythroblast count at delivery with the diagnosis of fetal distress in labour was studied prospectively in three groups of singleton pregnancies delivering at term vaginally (55 infants), by elective caesarean section (39 infants), or by emergency caesarean section for abnormal intrapartum fetal heart rate patterns (55 infants). In the emergency caesarean section group the umbilical cord blood arterial pH was significantly lower and the leucocyte and erythroblast counts were higher than in the elective caesarean section group. Comparison of the emergency caesarean section and spontaneous vaginal delivery groups showed significant differences for pH and erythroblast count, but not for leucocyte count. In the spontaneous vaginal delivery group erythroblastosis was associated with umbilical cord blood pH, whereas leucocytosis was associated with the length of labour. The five minute Apgar score was > or = 7 in all infants. This study suggests that leucocytosis is a non-specific response of the fetus to labour, whereas erythroblastosis reflects fetal tissue hypoxia. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (435K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Herson VC, Block C, Eisenfeld LI, Maderazo E, Krause PJ. Effect of labor and delivery on neonatal polymorphonuclear leukocyte number and function. Am J Perinatol. 1992 Jul;9(4):285–288. [PubMed]
- Thilaganathan B, Nicolaides KH. Erythroblastosis in birth asphyxia. Ultrasound Obstet Gynecol. 1992 Jan 1;2(1):15–17. [PubMed]
- Nicolaides KH, Thilaganathan B, Rodeck CH, Mibashan RS. Erythroblastosis and reticulocytosis in anemic fetuses. Am J Obstet Gynecol. 1988 Nov;159(5):1063–1065. [PubMed]
- Thilaganathan B, Salvesen DR, Abbas A, Ireland RM, Nicolaides KH. Fetal plasma erythropoietin concentration in red blood cell-isoimmunized pregnancies. Am J Obstet Gynecol. 1992 Nov;167(5):1292–1297. [PubMed]
- Snijders RJ, Abbas A, Melby O, Ireland RM, Nicolaides KH. Fetal plasma erythropoietin concentration in severe growth retardation. Am J Obstet Gynecol. 1993 Feb;168(2):615–619. [PubMed]
- Davies N, Snijders R, Nicolaides KH. Intra-uterine starvation and fetal leucocyte count. Fetal Diagn Ther. 1991;6(3-4):107–112. [PubMed]
- Davies NP, Buggins AG, Snijders RJ, Noble PN, Layton DM, Nicolaides KH. Fetal leucocyte count in rhesus disease. Arch Dis Child. 1992 Apr;67(4 Spec No):404–406. [PubMed]
- Low JA. The role of blood gas and acid-base assessment in the diagnosis of intrapartum fetal asphyxia. Am J Obstet Gynecol. 1988 Nov;159(5):1235–1240. [PubMed]
- Dennis J, Johnson A, Mutch L, Yudkin P, Johnson P. Acid-base status at birth and neurodevelopmental outcome at four and one-half years. Am J Obstet Gynecol. 1989 Jul;161(1):213–220. [PubMed]
- Fisher JW. Control of erythropoietin production. Proc Soc Exp Biol Med. 1983 Jul;173(3):289–305. [PubMed]
- Krantz SB. Erythropoietin. Blood. 1991 Feb 1;77(3):419–434. [PubMed]
- Philip AG, Tito AM. Increased nucleated red blood cell counts in small for gestational age infants with very low birth weight. Am J Dis Child. 1989 Feb;143(2):164–169. [PubMed]
|
This article has been