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Logo of jepicomhInstructions for authorsCurrent TOCJournal of Epidemiology and Community Health
J Epidemiol Community Health. Apr 1993; 47(2): 109–115.
PMCID: PMC1059737

Cancer in young people in the north of England, 1968-85: analysis by census wards.


OBJECTIVE--To determine whether the seeming excess of childhood leukaemia and lymphoma identified in Seascale, Cumbria, UK, remains unusual when put into a wider context. DESIGN--Analysis of cancer incidence by geographical area. SETTING--The north of England including the Northern and North Western Regional Health Authority regions and the Southport and South Sefton districts of the Mersey Regional Health Authority. SUBJECTS--Altogether 6686 cases of malignant disease in people under 25 years old. MEASUREMENTS AND MAIN RESULTS--Cases of cancer diagnosed before their 25th birthday between January 1968 and December 1985 identified from three regional cancer registries were allocated to a census ward on the basis of 'usual place of residence'. Population data were derived from the 1971 and 1981 censuses, and the cancer incidence was calculated for each ward. Of the 6686 cases, there were 1035 cases of acute lymphoblastic leukaemia and 361 of non-Hodgkins lymphoma. Wards were ranked by cancer incidence and Poisson probability, using different population bases. Seascale ward is the most highly ranked ward for acute lymphoblastic leukaemia for the time periods 1968-85 or 1968-76. It is not the most highly ranked for non-Hodgkins lymphoma. However, combining acute lymphoblastic leukaemia and non-Hodgkins lymphoma incidence gives an even more extreme position for Seascale. The most extreme Poisson probability for any of the analyses was that for brain tumours in the electoral ward of Ashton St Michael, Tameside (p = 0.000009). CONCLUSION--The incidence of acute lymphoblastic leukaemia and non-Hodgkins lymphoma in the Seascale ward remains high when put into a wider context. For other cancers there are wards with even more extreme Poisson probability values.

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Selected References

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  • Gardner MJ, Hall AJ, Downes S, Terrell JD. Follow up study of children born to mothers resident in Seascale, West Cumbria (birth cohort). Br Med J (Clin Res Ed) 1987 Oct 3;295(6602):822–827. [PMC free article] [PubMed]
  • Gardner MJ, Hall AJ, Downes S, Terrell JD. Follow up study of children born elsewhere but attending schools in Seascale, West Cumbria (schools cohort). Br Med J (Clin Res Ed) 1987 Oct 3;295(6602):819–822. [PMC free article] [PubMed]
  • Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD. Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ. 1990 Feb 17;300(6722):423–429. [PMC free article] [PubMed]
  • Craft AW, Amineddine HA, Scott JE, Wagget J. The Northern region Children's malignant disease registry 1968-82: incidence and survival. Br J Cancer. 1987 Dec;56(6):853–858. [PMC free article] [PubMed]
  • Birch JM, Marsden HB, Jones PH, Pearson D, Blair V. Improvements in survival from childhood cancer: results of a population based survey over 30 years. Br Med J (Clin Res Ed) 1988 May 14;296(6633):1372–1376. [PMC free article] [PubMed]
  • Nwene U, Smith A. Assessing completeness of cancer registration in the north-western region of England by a method of independent comparison. Br J Cancer. 1982 Oct;46(4):635–639. [PMC free article] [PubMed]
  • Greaves MF. Speculations on the cause of childhood acute lymphoblastic leukemia. Leukemia. 1988 Feb;2(2):120–125. [PubMed]
  • Openshaw S, Craft AW, Charlton M, Birch JM. Investigation of leukaemia clusters by use of a Geographical Analysis Machine. Lancet. 1988 Feb 6;1(8580):272–273. [PubMed]
  • Stone RA. Investigations of excess environmental risks around putative sources: statistical problems and a proposed test. Stat Med. 1988 Jun;7(6):649–660. [PubMed]

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