• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jmedgeneJournal of Medical GeneticsVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Med Genet. Mar 1996; 33(3): 212–215.
PMCID: PMC1051869

Genetic referrals of Middle Eastern origin in a western city: inbreeding and disease profile.

Abstract

Inbreeding or consanguineous marriage is a common traditional practice in Middle Eastern cultures. Studies from various countries and communities of this region showed that the frequencies range from 20% to greater than 70%. Inbreeding is known to have adverse effects on morbidity and mortality, in particular with respect to autosomal recessive disorders. This study examined 200 couples representing all referrals of Middle Eastern origin seen at a large Clinical Genetics Unit in Montreal. They were compared with a similar sized group of different cultural backgrounds from among the same referrals. The rate of intercultural marriages and inbreeding was found to be 24% and 23.5% respectively in the Middle Eastern group, while they were 22.5% and 5% in the comparison group. Excluding the referrals for consanguinity only, the rate of inbreeding among the study group was 16.4%. Within the Middle Eastern group, autosomal recessive disorders were more than twice as common in the inbred than in the non-inbred families, the pattern of which is consistent with previous observations.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (630K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bittles AH, Mason WM, Greene J, Rao NA. Reproductive behavior and health in consanguineous marriages. Science. 1991 May 10;252(5007):789–794. [PubMed]
  • Khlat M, Khoury M. Inbreeding and diseases: demographic, genetic, and epidemiologic perspectives. Epidemiol Rev. 1991;13:28–41. [PubMed]
  • Khlat M. Social correlates of consanguineous marriages in Beirut: a population-based study. Hum Biol. 1988 Aug;60(4):541–548. [PubMed]
  • Khlat M. Consanguineous marriage and reproduction in Beirut, Lebanon. Am J Hum Genet. 1988 Aug;43(2):188–196. [PMC free article] [PubMed]
  • Al-Awadi SA, Naguib KK, Moussa MA, Farag TI, Teebi AS, el-Khalifa MY. The effect of consanguineous marriages on reproductive wastage. Clin Genet. 1986 May;29(5):384–388. [PubMed]
  • Benallègue A, Kedji F. Consanguinité et santé publique. Etude algérienne. Arch Fr Pediatr. 1984 Jun-Jul;41(6):435–440. [PubMed]
  • Hafez M, El-Tahan H, Awadalla M, El-Khayat H, Abdel-Gafar A, Ghoneim M. Consanguineous matings in the Egyptian population. J Med Genet. 1983 Feb;20(1):58–60. [PMC free article] [PubMed]
  • Naderi S. Congenital abnormalities in newborns of consanguineous and nonconsanguineous parents. Obstet Gynecol. 1979 Feb;53(2):195–199. [PubMed]
  • Khoury SA, Massad D. Consanguineous marriage in Jordan. Am J Med Genet. 1992 Jul 15;43(5):769–775. [PubMed]
  • Al-Awadi SA, Moussa MA, Naguib KK, Farag TI, Teebi AS, el-Khalifa M, el-Dossary L. Consanguinity among the Kuwaiti population. Clin Genet. 1985 May;27(5):483–486. [PubMed]
  • Khlat M. Consanguineous marriages in Beirut: time trends, spatial distribution. Soc Biol. 1988 Fall-Winter;35(3-4):324–330. [PubMed]
  • Jaber L, Merlob P, Bu X, Rotter JI, Shohat M. Marked parental consanguinity as a cause for increased major malformations in an Israeli Arab community. Am J Med Genet. 1992 Sep 1;44(1):1–6. [PubMed]
  • Freundlich E, Hino N. Consanguineous marriage among rural Arabs in Israel. Isr J Med Sci. 1984 Nov;20(11):1035–1038. [PubMed]
  • el-Hazmi MA, al-Swailem AR, Warsy AS, al-Swailem AM, Sulaimani R, al-Meshari AA. Consanguinity among the Saudi Arabian population. J Med Genet. 1995 Aug;32(8):623–626. [PMC free article] [PubMed]
  • Wong SS, Anokute CC. The effect of consanguinity on pregnancy outcome in Saudi Arabia. J R Soc Health. 1990 Aug;110(4):146–147. [PubMed]
  • Başaran N, Sayli BS, Başaran A, Solak M, Artan S, Stevenson JD. Consanguineous marriages in the Turkish population. Clin Genet. 1988 Nov;34(5):339–341. [PubMed]
  • Teebi AS. Autosomal recessive disorders among Arabs: an overview from Kuwait. J Med Genet. 1994 Mar;31(3):224–233. [PMC free article] [PubMed]

Articles from Journal of Medical Genetics are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...