• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of brjopthalBritish Journal of OphthalmologyCurrent TOCInstructions for authors
Br J Ophthalmol. Feb 1988; 72(2): 83–87.
PMCID: PMC1041377

Activated T lymphocytes in uveitis.


Two colour flow cytometry techniques were used to assess the activation stages of peripheral and intraocular T lymphocytes in uveitis. Increased numbers of T lymphocytes bearing the interleukin-2 (IL-2) receptors were found in intraocular fluids or peripheral blood or both of 35/51 patients with uveitis. This increased expression of IL-2 receptors on lymphocytes correlated with increased expression of other early T lymphocyte activation markers, HLA-DR and L-35. Both T helper cells (Leu-3A+) and suppressor cells (Leu 2A+) were activated in vivo. A positive correlation was seen between lymphocyte activation and clinical uveitis activity. In idiopathic uveitis activation of Leu-3A lymphocytes (helper/inducer) was significantly increased, and intraocular activation of the Leu-2A lymphocytes (cytotoxic/suppressor) was significantly decreased. These data show that some patients with idiopathic uveitis have a perturbation of T helper cells. Twenty-two of 31 patients with idiopathic uveitis, not associated with systemic disease, had increased peripheral T lymphocyte activation. This finding indicates that in some inflammations believed to be restricted to the eye an abnormal systemic immune activation exists.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (667K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kaplan HJ, Waldrep JC, Nicholson JK, Gordon D. Immunologic analysis of intraocular mononuclear cell infiltrates in uveitis. Arch Ophthalmol. 1984 Apr;102(4):572–575. [PubMed]
  • Freeman WR, Char DH, Garavoy MR, Lyon H. Microtechniques for flow cytometric analysis of aqueous humor lymphocytes. J Immunol Methods. 1984 Oct 26;73(2):447–455. [PubMed]
  • Deschênes J, Freeman WR, Char DH, Garovoy MR. Lymphocyte subpopulations in uveitis. Arch Ophthalmol. 1986 Feb;104(2):233–236. [PubMed]
  • Uchiyama T, Broder S, Waldmann TA. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J Immunol. 1981 Apr;126(4):1393–1397. [PubMed]
  • Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature. 1982 Nov 18;300(5889):267–269. [PubMed]
  • Miyawaki T, Yachie A, Uwadana N, Ohzeki S, Nagaoki T, Taniguchi N. Functional significance of Tac antigen expressed on activated human T lymphocytes: Tac antigen interacts with T cell growth factor in cellular proliferation. J Immunol. 1982 Dec;129(6):2474–2478. [PubMed]
  • Burmester GR, Jahn B, Gramatzki M, Zacher J, Kalden JR. Activated T cells in vivo and in vitro: divergence in expression of Tac and Ia antigens in the nonblastoid small T cells of inflammation and normal T cells activated in vitro. J Immunol. 1984 Sep;133(3):1230–1234. [PubMed]
  • Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL, Weiner HL. In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med. 1985 May 30;312(22):1405–1411. [PubMed]
  • HOGAN MJ, KIMURA SJ, THYGESON P. Signs and symptoms of uveitis. I. Anterior uveitis. Am J Ophthalmol. 1959 May;47(5 Pt 2):155–170. [PubMed]
  • KIMURA SJ, THYGESON P, HOGAN MJ. Signs and symptoms of uveitis. II. Classification of the posterior manifestations of uveitis. Am J Ophthalmol. 1959 May;47(5 Pt 2):171–176. [PubMed]
  • Kahn LS, Schlaegel TF, Jr, Weber JC, Biegel A. Serum immunoglobulins and uveitis. Arch Ophthalmol. 1983 Mar;101(3):458–459. [PubMed]
  • Char DH, Stein P, Masi R, Christensen M. Immune complexes in uveitis. Am J Ophthalmol. 1979 May;87(5):678–681. [PubMed]
  • Nussenblatt RB, Salinas-Carmona M, Leake W, Scher I. T lymphocyte subsets in uveitis. Am J Ophthalmol. 1983 May;95(5):614–621. [PubMed]
  • Murray PI, Rahi AH. New concepts in the control of ocular inflammation. Trans Ophthalmol Soc U K. 1985;104(Pt 2):152–158. [PubMed]
  • Caspi RR, Roberge FG, McAllister CG, el-Saied M, Kuwabara T, Gery I, Hanna E, Nussenblatt RB. T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J Immunol. 1986 Feb 1;136(3):928–933. [PubMed]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...