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Journal List > Br J Ophthalmol > v.66(6); Jun 1982

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Br J Ophthalmol. 1982 June; 66(6): 386–388.
PMCID: PMC1039805
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Oxytetracycline in the treatment of ocular rosacea: a double-blind trial.
R S Bartholomew, B J Reid, M J Cheesbrough, M Macdonald, and N R Galloway
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Abstract
Thirty-five patients with ocular rosacea were admitted to a trial of systemic oxytetracycline, 250 mg b.d. for 6 weeks. Oxytetracycline produced a significantly higher number of remissions than the placebo, 11/35. With repeated or continuous treatment 19/35 patients achieved a sustained remission for 8 months. There were no side effects. The nonspecific signs of ocular rosacea responded well to the treatment, but no permanent change in the conjunctival or corneal vascularisation occurred.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Sneddon IB. A clinical trial of tetracycline in rosacea. Br J Dermatol. 1966 Dec;78(12):649–652. [PubMed]
  • Marks R, Ellis J. Comparative effectiveness of tetracycline and ampicillin in rosacea. A controlled trial. Lancet. 1971 Nov 13;2(7733):1049–1052. [PubMed]
  • Osment LS, Hammack WJ. The long-term use of tetracycline in acne vulgaris: effect on blood elements. South Med J. 1970 Oct;63(10):1156–1158. [PubMed]
  • Gilgor RS. Complications of tetracycline therapy for acne. N C Med J. 1972 Apr;33(4):331–333. [PubMed]
  • Delaney TJ, Leppard BJ, MacDonald DM. Effects of long term treatment with tetracycline. Acta Derm Venereol. 1974;54(6):487–489. [PubMed]
  • Roper-Hall MJ. The ocular aspects of rosacea. Trans Ophthalmol Soc U K. 1966;86:727–732. [PubMed]
  • Marmion VJ. Tetracyclines in the treatment of ocular rosacea. Proc R Soc Med. 1969 Jan;62(1):11–12. [PubMed]
  • Brown SI, Shahinian L., Jr Diagnosis and treatment of ocular rosacea. Ophthalmology. 1978 Aug;85(8):779–786. [PubMed]
  • Jenkins MS, Brown SI, Lempert SL, Weinberg RJ. Ocular rosacea. Am J Ophthalmol. 1979 Sep;88(3 Pt 2):618–622. [PubMed]
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