• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Neurol Neurosurg Psychiatry. Nov 1986; 49(11): 1280–1287.
PMCID: PMC1029077

Visual evoked cortical potentials and pattern electroretinograms in Parkinson's disease and control subjects.

Abstract

Parkinson's disease patients have been shown to have abnormal visually evoked cortical potentials (VEPs) to pattern stimulation. Whereas dopamine is not an important neurotransmitter in the central visual pathways, the retina is rich in dopamine and, together with previous animal and human studies, this suggests that the abnormal VEPs in Parkinson's disease patients may be due to a biochemical and electrophysiological disorder in the retina. This hypothesis has been examined by studying the VEPs and pattern electroretinogram (PERG) of Parkinson's disease patients and matched control subjects. The amplitudes of the cortical and retinal evoked potentials were significantly reduced in Parkinson's disease patients compared with the control subjects and this could not be attributed to any particular feature of the disease or its treatment. There was a significant relationship between the VEP P100 latency and the PERG amplitude. Moreover for those subjects in whom there was an interocular difference in both cortical and retinal evoked potentials, the abnormality was more commonly found in the potentials from the same eye. These findings suggest that the abnormality of the VEP in Parkinson's disease patients is, at least in part, secondary to an abnormality of the retina itself.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bodis-Wollner I, Onofrj M. System diseases and visual evoked potential diagnosis in neurology: changes due to synaptic malfunction. Ann N Y Acad Sci. 1982;388:327–348. [PubMed]
  • Bodis-Wollner I, Yahr MD. Measurements of visual evoked potentials in Parkinson's disease. Brain. 1978 Dec;101(4):661–671. [PubMed]
  • Kupersmith MJ, Shakin E, Siegel IM, Lieberman A. Visual system abnormalities in patients with Parkinson's disease. Arch Neurol. 1982 May;39(5):284–286. [PubMed]
  • Tartaglione A, Pizio N, Bino G, Spadavecchia L, Favale E. VEP changes in Parkinson's disease are stimulus dependent. J Neurol Neurosurg Psychiatry. 1984 Mar;47(3):305–307. [PMC free article] [PubMed]
  • Hakim AM, Mathieson G. Dementia in Parkinson disease: a neuropathologic study. Neurology. 1979 Sep;29(9 Pt 1):1209–1214. [PubMed]
  • Dyer RS, Howell WE, MacPhail RC. Dopamine depletion slows retinal transmission. Exp Neurol. 1981 Feb;71(2):326–340. [PubMed]
  • Onofrj M, Bodis-Wollner I. Dopaminergic deficiency causes delayed visual evoked potentials in rats. Ann Neurol. 1982 May;11(5):484–490. [PubMed]
  • Iuvone PM, Galli CL, Garrison-Gund CK, Neff NH. Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurons. Science. 1978 Nov 24;202(4370):901–902. [PubMed]
  • Kramer SG. Dopamine: A retinal neurotransmitter. I. Retinal uptake, storage, and light-stimulated release of H3-dopamine in vivo. Invest Ophthalmol. 1971 Jun;10(6):438–452. [PubMed]
  • Kramer SG, Potts AM, Mangnall Y. Dopamine: a retinal neurotransmitter. II. Autoradiographic localization of H3-dopamine in the retina. Invest Ophthalmol. 1971 Aug;10(8):617–624. [PubMed]
  • Economou SG, Stefanis CN. Changes of electrooculogram (EOG) in Parkinson's disease. Acta Neurol Scand. 1978 Jul;58(1):44–52. [PubMed]
  • Cavallacci G, Perossini M. Intérêt clinique du test électrorétinographique dans la maladie de Parkinson. J Fr Ophtalmol. 1979 Dec;2(12):705–708. [PubMed]
  • Lawwill T. The bar-pattern electroretinogram for clinical evaluation of the central retina. Am J Ophthalmol. 1974 Jul;78(1):121–126. [PubMed]
  • Arden GB, Vaegan, Hogg CR. Clinical and experimental evidence that the pattern electroretinogram (PERG) is generated in more proximal retinal layers than the focal electroretinogram (FERG). Ann N Y Acad Sci. 1982;388:580–607. [PubMed]
  • Mafei L, Fiorentini A. Electroretinographic responses to alternating gratings before and after section of the optic nerve. Science. 1981 Feb 27;211(4485):953–955. [PubMed]
  • Arden GB, Vaegan, Hogg CR, Powell DJ, Carter RM. Pattern ERGs are abnormal in many amblyopes. Trans Ophthalmol Soc U K. 1980;100(4):453–460. [PubMed]
  • Fiorentini A, Maffei L, Pirchio M, Spinelli D, Porciatti V. The ERG in response to alternating gratings in patients with diseases of the peripheral visual pathway. Invest Ophthalmol Vis Sci. 1981 Sep;21(3):490–493. [PubMed]
  • Persson HE, Wanger P. Pattern-reversal electroretinograms in squint amblyopia, artificial anisometropia and simulated eccentric fixation. Acta Ophthalmol (Copenh) 1982 Feb;60(1):123–132. [PubMed]
  • Sherman J. Simultaneous pattern-reversal electroretinograms and visual evoked potentials in diseases of the macula and optic nerve. Ann N Y Acad Sci. 1982;388:214–226. [PubMed]
  • Sokol S, Nadler D. Simultaneous electroretinograms and visually evoked potentials from adult amblyopes in response to a pattern stimulus. Invest Ophthalmol Vis Sci. 1979 Aug;18(8):848–855. [PubMed]
  • Armington JC. Simultaneous electroretinograms and evoked potentials. Ann N Y Acad Sci. 1982;388:572–579. [PubMed]
  • Sokol S, Jones K, Nadler D. Comparison of the spatial response properties of the human retina and cortex as measured by simultaneously recorded pattern ERGs and VEPs. Vision Res. 1983;23(7):723–727. [PubMed]
  • Dinner DS, Lüders H, Hanson M, Lesser RP, Klem G. Pattern evoked potentials (PEPs) in Parkinson's disease. Neurology. 1985 Apr;35(4):610–613. [PubMed]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...