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Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryCurrent TOCInstructions for authors
J Neurol Neurosurg Psychiatry. Nov 1986; 49(11): 1221–1226.
PMCID: PMC1029068

Cerebral amyloid angiopathy in dementia and old age.

Abstract

A necropsy study of 159 elderly patients drawn mainly from a prospectively assessed geriatric hospital population was carried out to investigate the relationship of cerebral amyloid angiopathy to Alzheimer's disease, other CNS disease and ageing. About half the patients were demented and the majority of these had Alzheimer's disease. In Alzheimer's disease there was an incidence of cerebral amyloid angiopathy of 82%. Among the other groups of patients, both demented and non-demented, the incidence of cerebral amyloid angiopathy was a little over 30%, and remained constant between 60 and 102 years of age.

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Selected References

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  • Gudmundsson G, Hallgrímsson J, Jónasson TA, Bjarnason O. Hereditary cerebral haemorrhage with amyloidosis. Brain. 1972;95(2):387–404. [PubMed]
  • Griffiths RA, Mortimer TF, Oppenheimer DR, Spalding JM. Congophilic angiopathy of the brain: a clinical and pathological report on two siblings. J Neurol Neurosurg Psychiatry. 1982 May;45(5):396–408. [PMC free article] [PubMed]
  • Jellinger K. Cerebrovascular amyloidosis with cerebral hemorrhage. J Neurol. 1977 Feb 17;214(3):195–206. [PubMed]
  • Lee SS, Stemmermann GN. Congophilic angiopathy and cerebral hemorrhage. Arch Pathol Lab Med. 1978 Jun;102(6):317–321. [PubMed]
  • Mandybur TI, Bates SR. Fatal massive intracerebral hemorrhage complicating cerebral amyloid angiopathy. Arch Neurol. 1978 Apr;35(4):246–248. [PubMed]
  • Okazaki H, Reagan TJ, Campbell RJ. Clinicopathologic studies of primary cerebral amyloid angiopathy. Mayo Clin Proc. 1979 Jan;54(1):22–31. [PubMed]
  • Gilbert JJ, Vinters HV. Cerebral amyloid angiopathy: incidence and complications in the aging brain. I. Cerebral hemorrhage. Stroke. 1983 Nov-Dec;14(6):915–923. [PubMed]
  • Kalyan-Raman UP, Kalyan-Raman K. Cerebral amyloid angiopathy causing intracranial hemorrhage. Ann Neurol. 1984 Sep;16(3):321–329. [PubMed]
  • Ishii N, Nishihara Y, Horie A. Amyloid angiopathy and lobar cerebral haemorrhage. J Neurol Neurosurg Psychiatry. 1984 Nov;47(11):1203–1210. [PMC free article] [PubMed]
  • Cosgrove GR, Leblanc R, Meagher-Villemure K, Ethier R. Cerebral amyloid angiopathy. Neurology. 1985 May;35(5):625–631. [PubMed]
  • Wilcock GK, Esiri MM. Plaques, tangles and dementia. A quantitative study. J Neurol Sci. 1982 Nov;56(2-3):343–356. [PubMed]
  • Wilcock GK, Esiri MM, Bowen DM, Smith CC. The nucleus basalis in Alzheimer's disease: cell counts and cortical biochemistry. Neuropathol Appl Neurobiol. 1983 May-Jun;9(3):175–179. [PubMed]
  • Chapel HM, Esiri MM, Wilcock GK. Immunoglobulin and other proteins in the cerebrospinal fluid of patients with Alzheimer's disease. J Clin Pathol. 1984 Jun;37(6):697–699. [PMC free article] [PubMed]
  • Hare M. Clinical check list for diagnosis of dementia. Br Med J. 1978 Jul 22;2(6132):266–267. [PMC free article] [PubMed]
  • Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing. 1972 Nov;1(4):233–238. [PubMed]
  • Cross RB. Demonstration of neurofibrillary tangles in paraffin sections: a quick and simple method using a modification of Palmgren's method. Med Lab Sci. 1982 Jan;39(1):67–69. [PubMed]
  • Mandybur TI. The incidence of cerebral amyloid angiopathy in Alzheimer's disease. Neurology. 1975 Feb;25(2):120–126. [PubMed]
  • Mountjoy CQ, Tomlinson BE, Gibson PH. Amyloid and senile plaques and cerebral blood vessels. A semi-quantitative investigation of a possible relationship. J Neurol Sci. 1982 Nov-Dec;57(1):89–103. [PubMed]
  • Torack RM. Congophilic angiopathy complicated by surgery and massive hemorrhage. A light and electron microscopic study. Am J Pathol. 1975 Nov;81(2):349–366. [PMC free article] [PubMed]
  • Morimatsu M, Hirai S, Muramatsu A, Yoshikawa M. Senile degenerative brain lesions and dementia. J Am Geriatr Soc. 1975 Sep;23(9):390–406. [PubMed]
  • Vinters HV, Gilbert JJ. Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes. Stroke. 1983 Nov-Dec;14(6):924–928. [PubMed]
  • Powers JM, Schlaepfer WW, Willingham MC, Hall BJ. An immunoperoxidase study of senile cerebral amyloidosis with pathogenetic considerations. J Neuropathol Exp Neurol. 1981 Nov;40(6):592–612. [PubMed]
  • Cohen DH, Feiner H, Jensson O, Frangione B. Amyloid fibril in hereditary cerebral hemorrhage with amyloidosis (HCHWA) is related to the gastroentero-pancreatic neuroendocrine protein, gamma trace. J Exp Med. 1983 Aug 1;158(2):623–628. [PMC free article] [PubMed]
  • Grubb A, Jensson O, Gudmundsson G, Arnason A, Löfberg H, Malm J. Abnormal metabolism of gamma-trace alkaline microprotein. The basic defect in hereditary cerebral hemorrhage with amyloidosis. N Engl J Med. 1984 Dec 13;311(24):1547–1549. [PubMed]

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