• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jnnpsycJournal of Neurology, Neurosurgery and PsychiatryCurrent TOCInstructions for authors
J Neurol Neurosurg Psychiatry. Dec 1985; 48(12): 1213–1219.
PMCID: PMC1028604

A potential application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas.

Abstract

After intravenous injection of therapeutic doses of bleomycin only small amounts could be measured in glioma tissue obtained at operation in patients with malignant gliomas and the drug was rapidly cleared from the blood (T1/2 = 2 hrs). Negatively charged liposomes injected through Ommaya reservoirs into the glioma tumour bed were tolerated without observable side effect. The appearance of bleomycin in the blood and urinary clearance after intracerebral injection of bleomycin entrapped within negatively charged liposomes through an Ommaya reservoir in patients with malignant gliomas was decreased as compared with levels when free bleomycin was injected. These preliminary observations suggest a role of drugs entrapped within liposomes as a depot preparation in the treatment of human cerebral gliomas.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (804K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Takeuchi K. A clinical trial of intravenous bleomycin in the treatment of brain tumors. Int J Clin Pharmacol Biopharm. 1975 Dec;12(4):419–426. [PubMed]
  • Firth G, Oliver AS, McKeran RO. Studies on the use of antimitotic drugs entrapped within liposomes and of their action on a human glioma cell line. J Neurol Sci. 1984 Feb;63(2):153–165. [PubMed]
  • Firth G, Oliver AS, McKeran RO. Studies on the intracerebral injection of bleomycin free and entrapped within liposomes in the rat. J Neurol Neurosurg Psychiatry. 1984 Jun;47(6):585–589. [PMC free article] [PubMed]
  • Oliver AS, Firth G, McKeran RO. Studies on the intracerebral injection of vincristine free and entrapped within liposomes in the rat. J Neurol Sci. 1985 Apr;68(1):25–30. [PubMed]
  • Luqman WA, Matej LA, Smith ML. Comparison of prolactin levels in human semen and seminal plasma. J Endocrinol. 1979 Apr;81(1):131–133. [PubMed]
  • Szoka F, Jr, Papahadjopoulos D. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4194–4198. [PMC free article] [PubMed]
  • Pittillo RF, Woolley C, Rice LS. Bleomycin, and antitumor antibiotic: improved microbiological assay and tissue distribution studies in normal mice. Appl Microbiol. 1971 Oct;22(4):564–566. [PMC free article] [PubMed]
  • Adams DH, Joyce G, Richardson VJ, Ryman BE, Wiśniewski HM. Liposome toxicity in the mouse central nervous system. J Neurol Sci. 1977 Mar;31(2):173–179. [PubMed]
  • Leserman LD, Machy P, Barbet J. Cell-specific drug transfer from liposomes bearing monoclonal antibodies. Nature. 1981 Sep 17;293(5829):226–228. [PubMed]
  • Umezawa H, Maeda K, Takeuchi T, Okami Y. New antibiotics, bleomycin A and B. J Antibiot (Tokyo) 1966 Sep;19(5):200–209. [PubMed]
  • Hayakawa T, Ushio Y, Mogami H, Horibata K. The uptake, distribution and anti-tumor activity of bleomycin in gliomas in the mouse. Eur J Cancer. 1974 Mar;10(3):137–142. [PubMed]
  • Hayakawa T, Ushio Y, Morimoto K, Hasegawa H, Mogami H. Uptake of bleomycin by human brain tumours. J Neurol Neurosurg Psychiatry. 1976 Apr;39(4):341–349. [PMC free article] [PubMed]

Articles from Journal of Neurology, Neurosurgery, and Psychiatry are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...