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J Neurol Neurosurg Psychiatry. Nov 1984; 47(11): 1182–1191.
PMCID: PMC1028084

Studies on regional cerebral oxygen utilisation and cognitive function in multiple sclerosis.


Regional cerebral oxygen utilisation (rCMRO2), oxygen extraction (rOER), blood flow (rCBF), and blood volume (rCBV) have been determined for fifteen patients with multiple sclerosis in remission using positron emission tomography (PET). Cerebral oxygen utilisation and blood flow were significantly reduced in both white matter and peripheral cortical grey matter in the multiple sclerosis patients compared to a group of normal controls. No evidence of regional cerebral ischaemia in the multiple sclerosis group was found. Lowest levels of cerebral oxygen utilisation were found in patients with cerebral atrophy, and in patients in whom a significant fall in present full-scale IQ from estimated pre-morbid levels had occurred. No correlation was found between rCMRO2 values and severity of locomotor dysfunction or clinical disease duration.

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Selected References

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  • BROWNELL B, HUGHES JT. The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1962 Nov;25:315–320. [PMC free article] [PubMed]
  • Gyldensted C. Computer tomography of the cerebrum in multiple sclerosis. Neuroradiology. 1976 Oct 27;12(1):33–42. [PubMed]
  • Young IR, Hall AS, Pallis CA, Legg NJ, Bydder GM, Steiner RE. Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet. 1981 Nov 14;2(8255):1063–1066. [PubMed]
  • Lukes SA, Crooks LE, Aminoff MJ, Kaufman L, Panitch HS, Mills C, Norman D. Nuclear magnetic resonance imaging in multiple sclerosis. Ann Neurol. 1983 Jun;13(6):592–601. [PubMed]
  • Peyser JM, Edwards KR, Poser CM, Filskov SB. Cognitive function in patients with multiple sclerosis. Arch Neurol. 1980 Sep;37(9):577–579. [PubMed]
  • Marsh GG. Disability and intellectual function in multiple sclerosis patients. J Nerv Ment Dis. 1980 Dec;168(12):758–762. [PubMed]
  • Reitan RM, Reed JC, Dyken ML. Cognitive, psychomotor, and motor correlates of multiple sclerosis. J Nerv Ment Dis. 1971 Sep;153(3):218–224. [PubMed]
  • Jambor KL. Cognitive functioning in multiple sclerosis. Br J Psychiatry. 1969 Jul;115(524):765–775. [PubMed]
  • Neubauer RA. Exposure of multiple sclerosis patients to hyperbaric oxygen at 1.5--2 ATA. A preliminary report. J Fla Med Assoc. 1980 May;67(5):498–504. [PubMed]
  • Fischer BH, Marks M, Reich T. Hyperbaric-oxygen treatment of multiple sclerosis. A randomized, placebo-controlled, double-blind study. N Engl J Med. 1983 Jan 27;308(4):181–186. [PubMed]
  • Hansbrough JF, Piacentine JG, Eiseman B. Immunosuppression by hyperbaric oxygen. Surgery. 1980 Jun;87(6):662–667. [PubMed]
  • Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. [PubMed]
  • Nelson HE, O'Connell A. Dementia: the estimation of premorbid intelligence levels using the New Adult Reading Test. Cortex. 1978 Jun;14(2):234–244. [PubMed]
  • McKenna P, Pratt RT. The effect of unilateral non-dominant ECT on memory and perceptual functions. Br J Psychiatry. 1983 Mar;142:276–279. [PubMed]
  • Frackowiak RS, Lenzi GL, Jones T, Heather JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr. 1980 Dec;4(6):727–736. [PubMed]
  • Phelps ME, Huang SC, Hoffman EJ, Kuhl DE. Validation of tomographic measurement of cerebral blood volume with C-11-labeled carboxyhemoglobin. J Nucl Med. 1979 Apr;20(4):328–334. [PubMed]
  • Lammertsma AA, Jones T. Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metab. 1983 Dec;3(4):416–424. [PubMed]
  • Wise RJ, Bernardi S, Frackowiak RS, Legg NJ, Jones T. Serial observations on the pathophysiology of acute stroke. The transition from ischaemia to infarction as reflected in regional oxygen extraction. Brain. 1983 Mar;106(Pt 1):197–222. [PubMed]
  • Frackowiak RS, Pozzilli C, Legg NJ, Du Boulay GH, Marshall J, Lenzi GL, Jones T. Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain. 1981 Dec;104(Pt 4):753–778. [PubMed]
  • Hoffman EJ, Huang SC, Phelps ME. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr. 1979 Jun;3(3):299–308. [PubMed]
  • Lammertsma AA, Jones T, Frackowiak RS, Lenzi GL. A theoretical study of the steady-state model for measuring regional cerebral blood flow and oxygen utilisation using oxygen-15. J Comput Assist Tomogr. 1981 Aug;5(4):544–550. [PubMed]

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