• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of brjindmedLink to Publisher's site
Br J Ind Med. Apr 1989; 46(4): 271–276.
PMCID: PMC1009766

Inflammation generating potential of long and short fibre amosite asbestos samples.

Abstract

Previous studies have shown that long thin asbestos fibres are more pathogenic in in vivo and more active in in vitro assays than short fibre samples. In the present study a long fibre amosite asbestos sample and a short fibre sample prepared from it were tested for ability to cause inflammation in the peritoneal cavity of the mouse; a UICC sample intermediate in fibre size and an inert compact dust, TiO2, were also tested. The ability of the dust samples to cause inflammation, as judged by macrophage and neutrophil recruitment, was ranked in the order long fibre greater than UICC greater than short fibre greater than TiO2. Ability of amosite samples to cause inflammation was therefore related to the proportion of long fibres. The enhanced ability of long fibres to cause inflammation and cause macrophage activation is probably a key factor in the ability of long fibres to cause pulmonary fibrosis and may also be important in fibre carcinogenesis.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (830K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Davis JM, Addison J, Bolton RE, Donaldson K, Jones AD, Smith T. The pathogenicity of long versus short fibre samples of amosite asbestos administered to rats by inhalation and intraperitoneal injection. Br J Exp Pathol. 1986 Jun;67(3):415–430. [PMC free article] [PubMed]
  • Brown GM, Cowie H, Davis JM, Donaldson K. In vitro assays for detecting carcinogenic mineral fibres: a comparison of two assays and the role of fibre size. Carcinogenesis. 1986 Dec;7(12):1971–1974. [PubMed]
  • Keogh BA, Crystal RG. Alveolitis: the key to the interstitial lung disorders. Thorax. 1982 Jan;37(1):1–10. [PMC free article] [PubMed]
  • Janoff A, White R, Carp H, Harel S, Dearing R, Lee D. Lung injury induced by leukocytic proteases. Am J Pathol. 1979 Oct;97(1):111–136. [PMC free article] [PubMed]
  • Bégin R, Rola-Pleszczynski M, Massé S, Nadeau D, Drapeau G. Assessment of progression of asbestosis in the sheep model by bronchoalveolar lavage and pulmonary function tests. Thorax. 1983 Jun;38(6):449–457. [PMC free article] [PubMed]
  • Davis JM, Beckett ST, Bolton RE, Collings P, Middleton AP. Mass and number of fibres in the pathogenesis of asbestos-related lung disease in rats. Br J Cancer. 1978 May;37(5):673–688. [PMC free article] [PubMed]
  • Donaldson K, Bolton RE, Brown D, Douglas A. An improved macrophage spreading assay--a simple and effective measure of activation. Immunol Commun. 1984;13(3):229–244. [PubMed]
  • Davis JM. The use of animal models for studies on asbestos bioeffects. Ann N Y Acad Sci. 1979;330:795–798. [PubMed]
  • Lemaire I, Beaudoin H, Dubois C. Cytokine regulation of lung fibroblast proliferation. Pulmonary and systemic changes in asbestos-induced pulmonary fibrosis. Am Rev Respir Dis. 1986 Oct;134(4):653–658. [PubMed]
  • Gellert AR, Langford JA, Winter RJ, Uthayakumar S, Sinha G, Rudd RM. Asbestosis: assessment by bronchoalveolar lavage and measurement of pulmonary epithelial permeability. Thorax. 1985 Jul;40(7):508–514. [PMC free article] [PubMed]
  • Martin TR, Chi EY, Covert DS, Hodson WA, Kessler DE, Moore WE, Altman LC, Butler J. Comparative effects of inhaled volcanic ash and quartz in rats. Am Rev Respir Dis. 1983 Jul;128(1):144–152. [PubMed]
  • Martin BM, Gimbrone MA, Jr, Unanue ER, Cotran RS. Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor. J Immunol. 1981 Apr;126(4):1510–1515. [PubMed]
  • Mossman BT, Craighead JE. Mechanisms of asbestos carcinogenesis. Environ Res. 1981 Aug;25(2):269–280. [PubMed]
  • Sporn MB, Roberts AB. Peptide growth factors and inflammation, tissue repair, and cancer. J Clin Invest. 1986 Aug;78(2):329–332. [PMC free article] [PubMed]
  • Soter NA, Wasserman SI, Austen KF. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. N Engl J Med. 1976 Mar 25;294(13):687–690. [PubMed]

Articles from British Journal of Industrial Medicine are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links