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Br J Ind Med. Sep 1987; 44(9): 627–632.
PMCID: PMC1007888

Allergy to laboratory animals: a prospective study of its incidence and of the influence of atopy on its development.


The pattern of incidence of allergy to laboratory animals (ALA) has been studied prospectively in 383 individuals occupationally exposed to rodents and to rabbits. The incidence of the disease after one year of exposure to animals fell from 37% in 1980 and 1981 to 20% in 1982, 10% in 1983, and 12% in 1984. A similar reduction was noted after two and three years of exposure in the 1982 and 1983 cohorts. The reduction in incidence coincided with the introduction of a site order and code of practice for working with animals and an education programme designed to focus awareness on the problem. Although rats were believed to be the major cause of the disease, objective measurements of IgE antibody against rat urine allergen were positive in only half the symptomatic individuals. Antibodies to different animal derived allergens were, however, found in several other personnel. Symptoms were generally of mild or moderate intensity and affected mainly the nose, eyes, and skin; chest symptoms were found in only 1.6% of the exposed population. A study of the influence of atopy on the development of ALA showed that after one year of exposure to animals a significantly greater proportion of atopic individuals became symptomatic (19-43% compared with 3-6%). After two and three years of exposure, however, this discrepancy was not maintained, with more non-atopic individuals developing the disease.

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Selected References

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  • Lincoln TA, Bolton NE, Garrett AS., Jr Occupational allergy to animal dander and sera. J Occup Med. 1974 Jul;16(7):465–469. [PubMed]
  • Lutsky II, Neuman I. Laboratory animal dander allergy: I. An occupational disease. Ann Allergy. 1975 Oct;35(4):201–205. [PubMed]
  • Lutsky I, Toshner D. A review of allergic respiratory disease in laboratory animal workers. Lab Anim Sci. 1978 Dec;28(6):751–756. [PubMed]
  • Gross NJ. Allergy to laboratory animals: epidemiologic, clinical, and physiologic aspects, and a trial of cromolyn in its management. J Allergy Clin Immunol. 1980 Aug;66(2):158–165. [PubMed]
  • Cockcroft A, Edwards J, McCarthy P, Andersson N. Allergy in laboratory animal workers. Lancet. 1981 Apr 11;1(8224):827–830. [PubMed]
  • Davies GE, McArdle LA. Allergy to laboratory animals: a survey by questionnaire. Int Arch Allergy Appl Immunol. 1981;64(3):302–307. [PubMed]
  • Dewdney Janet M. Allergy induced by exposure to animals. J R Soc Med. 1981 Dec;74(12):928–932. [PMC free article]
  • Lutsky II, Kalbfleisch JH, Fink JN. Occupational allergy to laboratory animals: employer practices. J Occup Med. 1983 May;25(5):372–376. [PubMed]
  • Davies GE, Thompson AV, Niewola Z, Burrows GE, Teasdale EL, Bird DJ, Phillips DA. Allergy to laboratory animals: a retrospective and a prospective study. Br J Ind Med. 1983 Nov;40(4):442–449. [PMC free article] [PubMed]
  • Agrup G, Belin L, Sjöstedt L, Skerfving S. Allergy to laboratory animals in laboratory technicians and animal keepers. Br J Ind Med. 1986 Mar;43(3):192–198. [PMC free article] [PubMed]
  • Allgrove J, Chayen J, O'Riordan JL. The cytochemical bioassay of parathyroid hormone: further experience. J Immunoassay. 1983;4(1):1–19. [PubMed]
  • Ceska M, Eriksson R, Varga JM. Radioimmunosorbent assay of allergens. J Allergy Clin Immunol. 1972 Jan;49(1):1–9. [PubMed]
  • Soter NA, Wasserman SI, Austen KF. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. N Engl J Med. 1976 Mar 25;294(13):687–690. [PubMed]

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