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Journal List > Ann Rheum Dis > v.36(3); Jun 1977

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Ann Rheum Dis. 1977 June; 36(3): 244–248.
PMCID: PMC1006673
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Penetration of naproxen and salicylate into inflammatory exudates in the rat.
N S Doherty, M Anttila, and P B Dean
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Abstract
Acute inflammation was induced in rats by subcutaneous implantation of plastic sponges, and the penetration of salicylate and naproxen into the inflammatory exudate was studied after oral dosing with these compounds. The penetration of intravenously administered 22Na and 125I-albumin was also studied. It was found that salicylate and 22Na penetrated very rapidly, reaching maximum concentration in the exudate within 3 hours of administration. In contrast, naproxen and 125I-albumin penetrated much more slowly, maximum concentrations in the exudates not being reached until 5 hours after administration. The significance of these results and the role of protein binding is discussed.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Emori HW, Champion GD, Bluestone R, Paulus HE. Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid. Ann Rheum Dis. 1973 Sep;32(5):433–435. [PubMed]
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  • Oie S, Frislid K. A fluorometric method for direct determination of total salicylate in plasma. Pharm Acta Helv. 1971 Oct–Nov;46(10):632–636. [PubMed]
  • ROSENTHAL RK, BAYLES TB, FREMONT-SMITH K. SIMULTANEOUS SALICYLATE CONCENTRATIONS IN SYNOVIAL FLUID AND PLASMA IN RHEUMATOID ARTHRITIS. Arthritis Rheum. 1964 Apr;7:103–109. [PubMed]
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