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Journal List > Ann Rheum Dis > v.51(5); May 1992

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Ann Rheum Dis. 1992 May; 51(5): 683–685.
PMCID: PMC1005709
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Evaluation of serum ferritin as a marker for adult Still's disease activity.
M Schwarz-Eywill, B Heilig, H Bauer, A Breitbart, and A Pezzutto
Department of Internal Medicine, Med Poliklink V, University of Heidelberg, Germany.
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Abstract
Extremely high serum ferritin values (greater than 10,000 micrograms/l) were detected in two patients with adult Still's disease. The ferritin concentrations decreased to normal after adequate treatment. During a one year follow up ferritin concentration was helpful in monitoring disease activity and guiding decisions about treatment. Raised concentrations of soluble interleukin 2 receptors (sCD25) were also found. Detection of ferritin values above 3000 micrograms/l should lead to the consideration of Still's disease when there is an acute febrile illness without evidence for bacterial or viral infections, serum ferritin being suitable for monitoring treatment.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Bywaters EG. Still's disease in the adult. Ann Rheum Dis. 1971 Mar;30(2):121–133. [PubMed]
  • Ohta A, Yamaguchi M, Kaneoka H, Nagayoshi T, Hiida M. Adult Still's disease: review of 228 cases from the literature. J Rheumatol. 1987 Dec;14(6):1139–1146. [PubMed]
  • Pelkonen P, Swanljung K, Siimes MA. Ferritinemia as an indicator of systemic disease activity in children with systemic juvenile rheumatoid arthritis. Acta Paediatr Scand. 1986 Jan;75(1):64–68. [PubMed]
  • Gonzalez-Hernandez T, Martin-Mola E, Fernandez-Zamorano A, Balsa-Criado A, de Miguel-Mendieta E. Serum ferritin can be useful for diagnosis in adult onset Still's disease. J Rheumatol. 1989 Mar;16(3):412–413. [PubMed]
  • Mirahmadi KS, Paul WL, Winer RL, Dabir-Vaziri N, Byer B, Gorman JT, Rosen SM. Serum ferritin level. Determinant of iron requirement in hemodialysis patients. JAMA. 1977 Aug 15;238(7):601–603. [PubMed]
  • Worwood M. Serum ferritin. Clin Sci (Lond). 1986 Mar;70(3):215–220. [PubMed]
  • Rogers JT, Bridges KR, Durmowicz GP, Glass J, Auron PE, Munro HN. Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1. J Biol Chem. 1990 Aug 25;265(24):14572–14578. [PubMed]
  • Atkinson BG, Blaker TW, Tomlinson J, Dean RL. Ferritin is a translationally regulated heat shock protein of avian reticulocytes. J Biol Chem. 1990 Aug 25;265(24):14156–14162. [PubMed]
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