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Ann Rheum Dis. Jan 1993; 52(1): 67–73.
PMCID: PMC1004961

Iron in joint inflammation.

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  • Morris CJ, Wainwright AC, Steven MM, Blake DR. The nature of iron deposits in haemophilic synovitis. An immunohistochemical, ultrastructural and X-ray microanalytical study. Virchows Arch A Pathol Anat Histopathol. 1984;404(1):75–85. [PubMed]
  • Bentley DP, Williams P. Serum ferritin concentration as an index of storage iron in rheumatoid arthritis. J Clin Pathol. 1974 Oct;27(10):786–788. [PMC free article] [PubMed]
  • Hansen TM, Hansen NE, Birgens HS, Hølund B, Lorenzen I. Serum ferritin and the assessment of iron deficiency in rheumatoid arthritis. Scand J Rheumatol. 1983;12(4):353–359. [PubMed]
  • Cartwright GE, Lee GR. The anaemia of chronic disorders. Br J Haematol. 1971 Aug;21(2):147–152. [PubMed]
  • Deiss A. Iron metabolism in reticuloendothelial cells. Semin Hematol. 1983 Apr;20(2):81–90. [PubMed]
  • Fillet G, Cook JD, Finch CA. Storage iron kinetics. VII. A biologic model for reticuloendothelial iron transport. J Clin Invest. 1974 Jun;53(6):1527–1533. [PMC free article] [PubMed]
  • Konijn AM, Hershko C. Ferritin synthesis in inflammation. I. Pathogenesis of impaired iron release. Br J Haematol. 1977 Sep;37(1):7–16. [PubMed]
  • Fillet G, Beguin Y, Baldelli L. Model of reticuloendothelial iron metabolism in humans: abnormal behavior in idiopathic hemochromatosis and in inflammation. Blood. 1989 Aug 1;74(2):844–851. [PubMed]
  • Houssiau FA, Devogelaer JP, Van Damme J, de Deuxchaisnes CN, Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988 Jun;31(6):784–788. [PubMed]
  • Darlington GJ, Wilson DR, Lachman LB. Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro. J Cell Biol. 1986 Sep;103(3):787–793. [PMC free article] [PubMed]
  • Andus T, Geiger T, Hirano T, Kishimoto T, Heinrich PC. Action of recombinant human interleukin 6, interleukin 1 beta and tumor necrosis factor alpha on the mRNA induction of acute-phase proteins. Eur J Immunol. 1988 May;18(5):739–746. [PubMed]
  • Brailsford S, Lunec J, Winyard P, Blake DR. A possible role for ferritin during inflammation. Free Radic Res Commun. 1985;1(2):101–109. [PubMed]
  • Smith RJ, Speziale SC, Bowman BJ. Properties of interleukin-1 as a complete secretagogue for human neutrophils. Biochem Biophys Res Commun. 1985 Aug 15;130(3):1233–1240. [PubMed]
  • Van Snick JL, Masson PL, Heremans JF. The involvement of lactoferrin in the hyposideremia of acute inflammation. J Exp Med. 1974 Oct 1;140(4):1068–1084. [PMC free article] [PubMed]
  • Brock JH, Esparza I. Failure of reticulocytes to take up iron from lactoferrin saturated by various methods. Br J Haematol. 1979 Jul;42(3):481–483. [PubMed]
  • Brock JH, Alvarez-Hernandez X. Modulation of macrophage iron metabolism by tumour necrosis factor and interleukin 1. FEMS Microbiol Immunol. 1989 Apr;1(5):309–309. [PubMed]
  • Muirden KD. Ferritin in synovial cells in patients with rheumatoid arthritis. Ann Rheum Dis. 1966 Sep;25(5):387–401. [PMC free article] [PubMed]
  • Muirden KD, Fraser JR, Clarris B. Ferritin formation by synovial cells exposed to haemoglobin in vitro. Ann Rheum Dis. 1967 May;26(3):251–259. [PMC free article] [PubMed]
  • Muirden KD, Senator GB. Iron in the synovial membrane in rheumatoid arthritis and other joint diseases. Ann Rheum Dis. 1968 Jan;27(1):38–48. [PMC free article] [PubMed]
  • Muirden KD. The anaemia of rheumatoid arthritis: the significance of iron deposits in the synovial membrane. Australas Ann Med. 1970 May;19(2):97–104. [PubMed]
  • Bennett RM, Williams ED, Lewis SM, Holt PJ. Synovial iron deposition in rheumatoid arthritis. Arthritis Rheum. 1973 May-Jun;16(3):298–304. [PubMed]
  • Yoshino S, Blake DR, Hewitt S, Morris C, Bacon PA. Effect of blood on the activity and persistence of antigen induced inflammation in the rat air pouch. Ann Rheum Dis. 1985 Jul;44(7):485–490. [PMC free article] [PubMed]
  • Lin JJ, Daniels-McQueen S, Patino MM, Gaffield L, Walden WE, Thach RE. Derepression of ferritin messenger RNA translation by hemin in vitro. Science. 1990 Jan 5;247(4938):74–77. [PubMed]
  • Morris CJ, Blake DR, Hewitt SD, Lunec J. Macrophage ferritin and iron deposition in the rat air pouch model of inflammatory synovitis. Ann Rheum Dis. 1987 Apr;46(4):334–338. [PMC free article] [PubMed]
  • Blake DR, Gallagher PJ, Potter AR, Bell MJ, Bacon PA. The effect of synovial iron on the progression of rheumatoid disease. A histologic assessment of patients with early rheumatoid synovitis. Arthritis Rheum. 1984 May;27(5):495–501. [PubMed]
  • Blake DR, Hall ND, Bacon PA, Dieppe PA, Halliwell B, Gutteridge JM. The importance of iron in rheumatoid disease. Lancet. 1981 Nov 21;2(8256):1142–1144. [PubMed]
  • Morris CJ, Blake DR, Wainwright AC, Steven MM. Relationship between iron deposits and tissue damage in the synovium: an ultrastructural study. Ann Rheum Dis. 1986 Jan;45(1):21–26. [PMC free article] [PubMed]
  • Rogers KR, Morris CJ, Blake DR. Cytoskeletal rearrangement by oxidative stress. Int J Tissue React. 1989;11(6):309–314. [PubMed]
  • Rowley D, Gutteridge JM, Blake D, Farr M, Halliwell B. Lipid peroxidation in rheumatoid arthritis: thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients. Clin Sci (Lond) 1984 Jun;66(6):691–695. [PubMed]
  • Gutteridge JM, Rowley DA, Halliwell B. Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Detection of 'free' iron in biological systems by using bleomycin-dependent degradation of DNA. Biochem J. 1981 Oct 1;199(1):263–265. [PMC free article] [PubMed]
  • Blake DR, Bacon PA, Eastham EJ, Brigham K. Synovial fluid ferritin in rheumatoid arthritis. Br Med J. 1980 Sep 13;281(6242):715–716. [PMC free article] [PubMed]
  • Biemond P, van Eijk HG, Swaak AJ, Koster JF. Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases. J Clin Invest. 1984 Jun;73(6):1576–1579. [PMC free article] [PubMed]
  • Blake DR, Bacon PA. Synovial fluid ferritin in rheumatoid arthritis: an index or cause of inflammation? Br Med J (Clin Res Ed) 1981 Jan 17;282(6259):189–189. [PMC free article] [PubMed]
  • Ahmadzadeh N, Shingu M, Nobunaga M. Iron-binding proteins and free iron in synovial fluids of rheumatoid arthritis patients. Clin Rheumatol. 1989 Sep;8(3):345–351. [PubMed]
  • Blake D, Bacon PA. Iron and rheumatoid disease. Lancet. 1982 Mar 13;1(8272):623–623. [PubMed]
  • Hansen TM, Hansen NE. Serum ferritin as indicator of iron responsive anaemia in patients with rheumatoid arthritis. Ann Rheum Dis. 1986 Jul;45(7):596–602. [PMC free article] [PubMed]
  • Reddy PS, Lewis M. The adverse effect of intravenous iron-dextran in rheumatoid arthritis. Arthritis Rheum. 1969 Aug;12(4):454–457. [PubMed]
  • Dabbagh AJ, Blake DR, Morris CJ. Effect of iron complexes on adjuvant arthritis in rats. Ann Rheum Dis. 1992 Apr;51(4):516–521. [PMC free article] [PubMed]
  • Lloyd KN, Williams P. Reactions to total dose infusion of iron dextran in rheumatoid arthritis. Br Med J. 1970 May 9;2(5705):323–325. [PMC free article] [PubMed]
  • Blake DR, Lunec J, Ahern M, Ring EF, Bradfield J, Gutteridge JM. Effect of intravenous iron dextran on rheumatoid synovitis. Ann Rheum Dis. 1985 Mar;44(3):183–188. [PMC free article] [PubMed]
  • Winyard PG, Blake DR, Chirico S, Gutteridge JM, Lunec J. Mechanism of exacerbation of rheumatoid synovitis by total-dose iron-dextran infusion: in-vivo demonstration of iron-promoted oxidant stress. Lancet. 1987 Jan 10;1(8524):69–72. [PubMed]
  • Andrews FJ, Morris CJ, Kondratowicz G, Blake DR. Effect of iron chelation on inflammatory joint disease. Ann Rheum Dis. 1987 Apr;46(4):327–333. [PMC free article] [PubMed]
  • Atmaca LS, Arcasoy A, Cavdar AO, Ozmert E. Levels of zinc in plasma, erythrocytes, and hair, and levels of serum copper in patients with retinitis pigmentosa in Turkey. Br J Ophthalmol. 1989 Jan;73(1):29–31. [PMC free article] [PubMed]
  • Hewitt SD, Hider RC, Sarpong P, Morris CJ, Blake DR. Investigation of the anti-inflammatory properties of hydroxypyridinones. Ann Rheum Dis. 1989 May;48(5):382–388. [PMC free article] [PubMed]
  • Schumacher HR, Kitridou RC. Synovitis of recent onset. A clinicopathologic study during the first month of disease. Arthritis Rheum. 1972 Sep-Oct;15(5):465–485. [PubMed]
  • Vogt A, Mishell RI, Dutton RW. Stimulation of DNA synthesis in cultures of mouse spleen cell suspensions by bovine transferrin. Exp Cell Res. 1969 Feb;54(2):195–200. [PubMed]
  • Tormey DC, Imrie RC, Mueller GC. Identification of transferrin as a lymphocyte growth promoter in human serum. Exp Cell Res. 1972 Sep;74(1):163–169. [PubMed]
  • Phillips JL, Azari P. Effect of iron transferrin on nucleic acid synthesis in phytohemagglutinin-stimulated human lymphocytes. Cell Immunol. 1975 Jan;15(1):94–99. [PubMed]
  • Brock JH, Rankin MC. Transferrin binding and iron uptake by mouse lymph node cells during transformation in response to concanavalin A. Immunology. 1981 Jun;43(2):393–398. [PMC free article] [PubMed]
  • Kay JE, Benzie CR. The role of the transferrin receptor in lymphocyte activation. Immunol Lett. 1986 Jan;12(1):55–58. [PubMed]
  • Nishiya K, Chiao JW, De Sousa M. Iron binding proteins in selected human peripheral blood cell sets: immunofluorescence. Br J Haematol. 1980 Oct;46(2):235–245. [PubMed]
  • Bryan CF, Leech SH, Bozelka B. The immunoregulatory nature of iron. II. Lymphocyte surface marker expression. J Leukoc Biol. 1986 Nov;40(5):589–600. [PubMed]
  • Good MF, Chapman DE, Powell LW, Halliday JW. The effect of iron (Fe3+) on the cloning efficiency of human memory T4+ lymphocytes. Clin Exp Immunol. 1986 Nov;66(2):340–347. [PMC free article] [PubMed]
  • Keown P, Descamps B. Suppression de la réaction lymphocytaire mixte par des globules rouges autologues et leurs constituants : une hypothèse nouvelle sur l'effet apparement tolérogène des transfusions sanguines en transplantation. C R Acad Sci Hebd Seances Acad Sci D. 1978 Oct 2;287(7):749–752. [PubMed]
  • Keown P, Descamps-Latscha B. In vitro suppression of cell-mediated immunity by ferroproteins and ferric salts. Cell Immunol. 1983 Sep;80(2):257–266. [PubMed]
  • de Sousa M, Dynesius-Trentham R, Mota-Garcia F, da Silva MT, Trentham DE. Activation of rat synovium by iron. Arthritis Rheum. 1988 May;31(5):653–661. [PubMed]
  • Roberts D, Davies J. Exacerbation of rheumatoid synovitis by iron-dextran infusion. Lancet. 1987 Feb 14;1(8529):391–391. [PubMed]
  • Weinberg ED. Iron withholding: a defense against infection and neoplasia. Physiol Rev. 1984 Jan;64(1):65–102. [PubMed]
  • van Asbeck BS, Marx JJ, Struyvenberg A, Verhoef J. Functional defects in phagocytic cells from patients with iron overload. J Infect. 1984 May;8(3):232–240. [PubMed]
  • Flament J, Goldman M, Waterlot Y, Dupont E, Wybran J, Vanherweghem JL. Impairment of phagocyte oxidative metabolism in hemodialyzed patients with iron overload. Clin Nephrol. 1986 May;25(5):227–230. [PubMed]
  • Ballart IJ, Estevez ME, Sen L, Diez RA, Giuntoli J, de Miani SA, Peñalver J. Progressive dysfunction of monocytes associated with iron overload and age in patients with thalassemia major. Blood. 1986 Jan;67(1):105–109. [PubMed]
  • Ward PA, Goldschmidt P, Greene ND. Suppressive effects of metal salts on leukocyte and fibroblastic function. J Reticuloendothel Soc. 1975 Nov;18(5):313–321. [PubMed]
  • Becroft DM, Dix MR, Farmer K. Intramuscular iron-dextran and susceptibility of neonates to bacterial infections. In vitro studies. Arch Dis Child. 1977 Oct;52(10):778–781. [PMC free article] [PubMed]
  • Fondu P. Les rôles du fer dans la défense contre les infections, et plus particulièrement l'importance des anomalies de la phagocytose au cours des états de surcharge en fer. Bull Mem Acad R Med Belg. 1989;144(3-4):223–231. [PubMed]
  • Hoepelman IM, Jaarsma EY, Verhoef J, Marx JJ. Effect of iron on polymorphonuclear granulocyte phagocytic capacity: role of oxidation state and effect of ascorbic acid. Br J Haematol. 1988 Dec;70(4):495–500. [PubMed]

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