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Ann Rheum Dis. Aug 1992; 51(8): 932–937.
PMCID: PMC1004797

A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee.


The natural history and prognostic factors of cartilage loss in osteoarthritis of the knee were studied in subjects from a general population survey on rheumatic diseases in 1975-8. Baseline data were collected by questionnaire, physical examination, and weightbearing anteroposterior knee radiographs. Follow up of the subjects aged 46-68 years with radiological osteoarthritis grade 2-4 (Kellgren) took place in 1988-9. Cartilage loss was assessed by two observers who scored the change in joint space width between two radiographs. Thirty four per cent had cartilage loss. Prognostic factors and adjusted odds ratios (ORs) (95% confidence intervals) were: body mass index OR = 11.1 (3.3 to 37.3) fourth v first quartile; body weight OR = 7.9 (2.6 to 24.0) third v first tertile; age OR = 3.8 (1.1 to 13.4) > 60 v < or = 49 years; Heberden's nodes OR = 6.0 (1.5 to 23.1); clinical diagnosis of generalised osteoarthritis OR = 3.3 (1.3 to 8.3); and previous bow legs or knock knees OR = 5.1 (1.1 to 23.1). The relation of age with cartilage loss was also confounded by the presence of Heberden's nodes or a diagnosis of generalised osteoarthritis. There was no statistically significant relation for gender, meniscectomy, injury, uric acid concentration, chondrocalcinosis, smoking, and occupation related factors, except possibly standing.

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  • Dieppe P. Osteoarthritis: are we asking the wrong questions? Br J Rheumatol. 1984 Aug;23(3):161–163. [PubMed]
  • Felson DT. Epidemiology of hip and knee osteoarthritis. Epidemiol Rev. 1988;10:1–28. [PubMed]
  • Massardo L, Watt I, Cushnaghan J, Dieppe P. Osteoarthritis of the knee joint: an eight year prospective study. Ann Rheum Dis. 1989 Nov;48(11):893–897. [PMC free article] [PubMed]
  • Danielsson L, Hernborg J. Clinical and roentgenologic study of knee joints with osteophytes. Clin Orthop Relat Res. 1970 Mar-Apr;69:302–312. [PubMed]
  • Hernborg JS, Nilsson BE. The natural course of untreated osteoarthritis of the knee. Clin Orthop Relat Res. 1977 Mar-Apr;(123):130–137. [PubMed]
  • Miller R, Kettelkamp DB, Laubenthal KN, Karagiorgos A, Smidt GL. Quantitative correlations in degenerative arthritis of the knee. J Bone Joint Surg Am. 1973 Jul;55(5):956–962. [PubMed]
  • Altman RD, Fries JF, Bloch DA, Carstens J, Cooke TD, Genant H, Gofton P, Groth H, McShane DJ, Murphy WA, et al. Radiographic assessment of progression in osteoarthritis. Arthritis Rheum. 1987 Nov;30(11):1214–1225. [PubMed]
  • Resnick D, Niwayama G, Goergen TG, Utsinger PD, Shapiro RF, Haselwood DH, Wiesner KB. Clinical, radiographic and pathologic abnormalities in calcium pyrophosphate dihydrate deposition disease (CPPD): pseudogout. Radiology. 1977 Jan;122(1):1–15. [PubMed]
  • Gordon TP, Smith M, Ebert B, McCredie M, Brooks PM. Articular chondrocalcinosis in a hospital population: an Australian experience. Aust N Z J Med. 1984 Oct;14(5):655–659. [PubMed]
  • Felson DT, Anderson JJ, Naimark A, Kannel W, Meenan RF. The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham Study. J Rheumatol. 1989 Sep;16(9):1241–1245. [PubMed]
  • Palotie A, Väisänen P, Ott J, Ryhänen L, Elima K, Vikkula M, Cheah K, Vuorio E, Peltonen L. Predisposition to familial osteoarthrosis linked to type II collagen gene. Lancet. 1989 Apr 29;1(8644):924–927. [PubMed]
  • Knowlton RG, Katzenstein PL, Moskowitz RW, Weaver EJ, Malemud CJ, Pathria MN, Jimenez SA, Prockop DJ. Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia. N Engl J Med. 1990 Feb 22;322(8):526–530. [PubMed]
  • Ala-Kokko L, Baldwin CT, Moskowitz RW, Prockop DJ. Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6565–6568. [PMC free article] [PubMed]
  • Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986 Aug;29(8):1039–1049. [PubMed]
  • Fife RS, Brandt KD, Braunstein EM, Katz BP, Shelbourne KD, Kalasinski LA, Ryan S. Relationship between arthroscopic evidence of cartilage damage and radiographic evidence of joint space narrowing in early osteoarthritis of the knee. Arthritis Rheum. 1991 Apr;34(4):377–382. [PubMed]
  • Anderson JJ, Felson DT. Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am J Epidemiol. 1988 Jul;128(1):179–189. [PubMed]
  • O'Hara BP, Urban JP, Maroudas A. Influence of cyclic loading on the nutrition of articular cartilage. Ann Rheum Dis. 1990 Jul;49(7):536–539. [PMC free article] [PubMed]
  • James MJ, Cleland LG, Rofe AM, Leslie AL. Intraarticular pressure and the relationship between synovial perfusion and metabolic demand. J Rheumatol. 1990 Apr;17(4):521–527. [PubMed]
  • Treadwell BV, Mankin HJ. The synthetic processes of articular cartilage. Clin Orthop Relat Res. 1986 Dec;(213):50–61. [PubMed]
  • van Kampen GP, Veldhuijzen JP, Kuijer R, van de Stadt RJ, Schipper CA. Cartilage response to mechanical force in high-density chondrocyte cultures. Arthritis Rheum. 1985 Apr;28(4):419–424. [PubMed]
  • Palmoski M, Perricone E, Brandt KD. Development and reversal of a proteoglycan aggregation defect in normal canine knee cartilage after immobilization. Arthritis Rheum. 1979 May;22(5):508–517. [PubMed]
  • Wu DD, Burr DB, Boyd RD, Radin EL. Bone and cartilage changes following experimental varus or valgus tibial angulation. J Orthop Res. 1990 Jul;8(4):572–585. [PubMed]
  • Pujol JP, Loyau G. Interleukin-1 and osteoarthritis. Life Sci. 1987 Sep 7;41(10):1187–1198. [PubMed]
  • Doherty M, Watt I, Dieppe P. Influence of primary generalised osteoarthritis on development of secondary osteoarthritis. Lancet. 1983 Jul 2;2(8340):8–11. [PubMed]

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