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Ann Rheum Dis. 1992 Mar; 51(3): 375–377.
PMCID: PMC1004665

Genetic control of the renal clearance of urate: a study of twins.


Although a genetic predisposition to gout has been recognised for centuries, its mechanism has never been defined. This study was designed to determine whether this factor might be the renal clearance of urate, which is an important determinant of the concentration of urate in serum. In this study the renal clearance of urate was examined in 37 pairs of normouricaemic twins to determine whether this resemblance was genetically mediated. Monozygotic twins had more similar values of urate clearance and fractional excretion of urate than dizygotic twins. The heritability of the renal clearance of urate was estimated as about 60% (95% confidence limits 40 to 100%), whereas the heritability of the fractional excretion of urate was 87% (confidence limits 45 to 100%). This study supports the hypothesis that genetic factors exert an important control on the renal clearance of urate, which determines some of the familiarity of hyperuricaemia and gout.

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Selected References

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  • Smyth CJ, Cotterman CW, Freyberg RH. THE GENETICS OF GOUT AND HYPERURICEMIA-AN ANALYSIS OF NINETEEN FAMILIES. J Clin Invest. 1948 Nov;27(6):749–759. [PMC free article] [PubMed]
  • HAUGE M, HARVALD B. Heredity in gout and hyperuricemia. Acta Med Scand. 1955 Nov 10;152(4):247–257. [PubMed]
  • Boyle JA, Greig WR, Jasani MK, Duncan A, Diver M, Buchanan WW. Relative roles of genetic and environmental factors in the control of serum uric acid levels in normouricaemic subjects. Ann Rheum Dis. 1967 May;26(3):234–238. [PMC free article] [PubMed]
  • Rieselbach RE, Sorensen LB, Shelp WD, Steele TH. Diminished renal urate secretion per nephron as a basis for primary gout. Ann Intern Med. 1970 Sep;73(3):359–366. [PubMed]
  • Scott JT, Pollard AC. Uric acid excretion in the relatives of patients with gout. Ann Rheum Dis. 1970 Jul;29(4):397–400. [PMC free article] [PubMed]
  • Kasriel J, Eaves L. The zygosity of twins: further evidence on the agreement between diagnosis by blood groups and written questionnaires. J Biosoc Sci. 1976 Jul;8(3):263–266. [PubMed]
  • Richardson JA, Philbin PE. The one-hour creatinine clearance rate in healthy men. JAMA. 1971 May 10;216(6):987–990. [PubMed]
  • LIDDLE L, SEEGMILLER JE, LASTER L. The enzymatic spectrophotometric method for determination of uric acid. J Lab Clin Med. 1959 Dec;54:903–913. [PubMed]
  • McIntosh JF, Möller E, Van Slyke DD. STUDIES OF UREA EXCRETION. III: The Influence of Body Size on Urea Output. J Clin Invest. 1928 Dec;6(3):467–483. [PMC free article] [PubMed]
  • Heath AC, Neale MC, Hewitt JK, Eaves LJ, Fulker DW. Testing structural equation models for twin data using LISREL. Behav Genet. 1989 Jan;19(1):9–35. [PubMed]
  • Whitfield JB, Martin NG. Inheritance and alcohol as factors influencing plasma uric acid levels. Acta Genet Med Gemellol (Roma) 1983;32(2):117–126. [PubMed]

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