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Logo of annrheumdAnnals of the Rheumatic DiseasesCurrent TOCInstructions for authors
Ann Rheum Dis. Nov 1991; 50(11): 792–796.
PMCID: PMC1004560

Morphometric analysis of blood vessels in synovial membranes obtained from clinically affected and unaffected knee joints of patients with rheumatoid arthritis.


Synovial tissues from inflamed and noninflamed knee joints of 13 patients with untreated rheumatoid arthritis were examined for vascular proliferation and morphological alteration of endothelial cells. Perivascular mononuclear cell infiltration and increased thickness of the synovial lining layer were noted in tissues from inflamed and noninflamed joints of patients with rheumatoid arthritis; vascular proliferation and morphological alteration of endothelial cells to resemble high endothelial venules were seen only in tissues from inflamed joints of patients with rheumatoid arthritis. These observations suggest that the migration of mononuclear cells from the peripheral blood to the perivascular areas and lining layer occurs before vascular proliferation and morphological alteration of endothelial cells.

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Selected References

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  • Brown RA, Weiss JB, Tomlinson IW, Phillips P, Kumar S. Angiogenic factor from synovial fluid resembling that from tumours. Lancet. 1980 Mar 29;1(8170):682–685. [PubMed]
  • Vracko R. Basal lamina layering in diabetes mellitus. Evidence for accelerated rate of cell death and cell regeneration. Diabetes. 1974 Feb;23(2):94–104. [PubMed]
  • Ausprunk DH, Folkman J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis. Microvasc Res. 1977 Jul;14(1):53–65. [PubMed]
  • Freemont AJ, Jones CJ, Bromley M, Andrews P. Changes in vascular endothelium related to lymphocyte collections in diseased synovia. Arthritis Rheum. 1983 Dec;26(12):1427–1433. [PubMed]
  • Iguchi T, Ziff M. Electron microscopic study of rheumatoid synovial vasculature. Intimate relationship between tall endothelium and lymphoid aggregation. J Clin Invest. 1986 Feb;77(2):355–361. [PMC free article] [PubMed]
  • Matsubara T, Ziff M. Basement membrane thickening of postcapillary venules and capillaries in rheumatoid synovium. Immunoelectron microscopic and electron microscopic morphometric analysis. Arthritis Rheum. 1987 Jan;30(1):18–30. [PubMed]
  • Schoefl GI. The migration of lymphocytes across the vascular endothelium in lymphoid tissue. A reexamination. J Exp Med. 1972 Sep 1;136(3):568–588. [PMC free article] [PubMed]
  • Anderson AO, Anderson ND. Lymphocyte emigration from high endothelial venules in rat lymph nodes. Immunology. 1976 Nov;31(5):731–748. [PMC free article] [PubMed]
  • Nightingale G, Hurley JV. Relationship between lymphocyte emigration and vascular endothelium in chronic inflammation. Pathology. 1978 Jan;10(1):27–44. [PubMed]
  • Harlan JM. Leukocyte-endothelial interactions. Blood. 1985 Mar;65(3):513–525. [PubMed]
  • Parrott DV, De Sousa MA, East J. Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice. J Exp Med. 1966 Jan 1;123(1):191–204. [PMC free article] [PubMed]
  • Pober JS, Gimbrone MA, Jr, Cotran RS, Reiss CS, Burakoff SJ, Fiers W, Ault KA. Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. J Exp Med. 1983 Apr 1;157(4):1339–1353. [PMC free article] [PubMed]
  • FitzGerald OM, Hess EV, Chance A, Highsmith RF. Quantitative studies of human monokine-induced endothelial cell elongation. J Leukoc Biol. 1987 May;41(5):421–428. [PubMed]
  • Yu CL, Haskard DO, Cavender D, Johnson AR, Ziff M. Human gamma interferon increases the binding of T lymphocytes to endothelial cells. Clin Exp Immunol. 1985 Dec;62(3):554–560. [PMC free article] [PubMed]
  • Soden M, Rooney M, Cullen A, Whelan A, Feighery C, Bresnihan B. Immunohistological features in the synovium obtained from clinically uninvolved knee joints of patients with rheumatoid arthritis. Br J Rheumatol. 1989 Aug;28(4):287–292. [PubMed]
  • ROPES MW, BENNETT GA, COBB S, JACOX R, JESSAR RA. 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958 Dec;9(4):175–176. [PubMed]
  • Edwards JC. The origin of type A synovial lining cells. Immunobiology. 1982 Apr;161(3-4):227–231. [PubMed]
  • Henderson B, Pettipher ER. The synovial lining cell: biology and pathobiology. Semin Arthritis Rheum. 1985 Aug;15(1):1–32. [PubMed]
  • Lalor PA, Mapp PI, Hall PA, Revell PA. Proliferative activity of cells in the synovium as demonstrated by a monoclonal antibody, Ki67. Rheumatol Int. 1987;7(5):183–186. [PubMed]
  • Van Boxel JA, Paget SA. Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med. 1975 Sep 11;293(11):517–520. [PubMed]
  • Ishikawa H, Ziff M. Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membrane. Arthritis Rheum. 1976 Jan-Feb;19(1):1–14. [PubMed]
  • Meijer CJ, de Graaff-Reitsma CB, Lafeber GJ, Cats A. In situ localization of lymphocyte subsets in synovial membranes of patients with rheumatoid arthritis with monoclonal antibodies. J Rheumatol. 1982 May-Jun;9(3):359–365. [PubMed]
  • Klareskog L, Forsum U, Wigren A, Wigzell H. Relationship between HLA-DR-expressing cells and T lymphocytes of different subsets in rheumatoid synovial tissue. Scand J Immunol. 1981 May;15(5):501–507. [PubMed]
  • Young CL, Adamson TC, 3rd, Vaughan JH, Fox RI. Immunohistologic characterization of synovial membrane lymphocytes in rheumatoid arthritis. Arthritis Rheum. 1984 Jan;27(1):32–39. [PubMed]
  • Konttinen YT, Reitamo S, Ranki A, Häyry P, Kankaanapä U, Wegelius O. Characterization of the immunocompetent cells of rheumatoid synovium from tissue sections and eluates. Arthritis Rheum. 1981 Jan;24(1):71–79. [PubMed]
  • Førre O, Thoen J, Dobloug JH, Egeland T, Kvien TK, Mellbye OJ, Natvig JB. Detection of T-lymphocyte subpopulation in the peripheral blood and the synovium of patients with rheumatoid arthritis and juvenile rheumatoid arthritis using monoclonal antibodies. Scand J Immunol. 1982 Feb;15(2):221–226. [PubMed]
  • Kurosaka M, Ziff M. Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J Exp Med. 1983 Oct 1;158(4):1191–1210. [PMC free article] [PubMed]
  • Yu CL, Haskard D, Cavender D, Ziff M. Effects of bacterial lipopolysaccharide on the binding of lymphocytes to endothelial cell monolayers. J Immunol. 1986 Jan;136(2):569–573. [PubMed]
  • Haskard D, Cavender D, Ziff M. Phorbol ester-stimulated T lymphocytes show enhanced adhesion to human endothelial cell monolayers. J Immunol. 1986 Sep 1;137(5):1429–1434. [PubMed]
  • Oppenheimer-Marks N, Ziff M. Binding of normal human mononuclear cells to blood vessels in rheumatoid arthritis synovial membrane. Arthritis Rheum. 1986 Jun;29(6):789–792. [PubMed]
  • Ashida ER, Johnson AR, Lipsky PE. Human endothelial cell-lymphocyte interaction. Endothelial cells function as accessory cells necessary for mitogen-induced human T lymphocyte activation in vitro. J Clin Invest. 1981 May;67(5):1490–1499. [PMC free article] [PubMed]
  • Wagner CR, Vetto RM, Burger DR. Expression of I-region-associated antigen (Ia) and interleukin 1 by subcultured human endothelial cells. Cell Immunol. 1985 Jun;93(1):91–104. [PubMed]
  • Stern DM, Bank I, Nawroth PP, Cassimeris J, Kisiel W, Fenton JW, 2nd, Dinarello C, Chess L, Jaffe EA. Self-regulation of procoagulant events on the endothelial cell surface. J Exp Med. 1985 Oct 1;162(4):1223–1235. [PMC free article] [PubMed]
  • Hale LP, Martin ME, McCollum DE, Nunley JA, Springer TA, Singer KH, Haynes BF. Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. Arthritis Rheum. 1989 Jan;32(1):22–30. [PubMed]
  • Jalkanen S, Steere AC, Fox RI, Butcher EC. A distinct endothelial cell recognition system that controls lymphocyte traffic into inflamed synovium. Science. 1986 Aug 1;233(4763):556–558. [PubMed]
  • Dumonde DC, Pulley MS, Paradinas FJ, Southcott BM, O'Connell D, Robinson MR, den Hollander F, Schuurs AH. Histological features of skin reactions to human lymphoid cell line lymphokine in patients with advanced cancer. J Pathol. 1982 Dec;138(4):289–308. [PubMed]
  • Stolpen AH, Guinan EC, Fiers W, Pober JS. Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. Am J Pathol. 1986 Apr;123(1):16–24. [PMC free article] [PubMed]
  • Cush JJ, Lipsky PE. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum. 1988 Oct;31(10):1230–1238. [PubMed]

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