Logo of annrheumdAnnals of the Rheumatic DiseasesVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. Jun 1991; 50(6): 351–353.
PMCID: PMC1004434

Close association of HLA-B51 and B52 in Israeli patients with Behçet's syndrome.


Epidemiological data, family history, clinical data, and HLA typing were studied in three groups of patients with Behçet's syndrome: six Israeli Ashkenazi Jews, 29 non-Ashkenazi Jews, and three Israeli Arabs. HLA-B51 and B52 were present in 24/38 (63%) and 8/38 (21%), respectively, of the patients compared with 13/151 (9%) of the control group for both cases, a relative risk of 18.2 and 2.8 respectively. The syndrome was found in six of the 34 families. Ninety five per cent of the affected family members were either B51 or B52 positive. Eleven of the 14 families (79%) chosen for study contained a close relative of the proband who had recurrent oral ulcers. All the relatives with ulcers, except for one, were B51 or B52 carriers. Recurrent oral ulcers in the patients with Behçet's syndrome began a few years before other manifestations of the syndrome occurred. Our findings suggest that (a) HLA-B51 and HLA-B52 are primarily associated with Behçet's disease of Israeli patients; (b) the familial occurrence of this syndrome is high and occurs predominantly in the B5 positive group; (c) recurrent oral ulcers may be the first symptom of Behçet's syndrome, appearing early in life; HLA analysis can provide the clue for a correct diagnosis; (d) ulcer recurrence is common among members of a family containing a patient with Behçet's syndrome.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (446K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ohno S, Ohguchi M, Hirose S, Matsuda H, Wakisaka A, Aizawa M. Close association of HLA-Bw51 with Behçet's disease. Arch Ophthalmol. 1982 Sep;100(9):1455–1458. [PubMed]
  • Chamberlain MA. A family study of Behcet's syndrome. Ann Rheum Dis. 1978 Oct;37(5):459–465. [PMC free article] [PubMed]
  • Challacombe SJ, Batchelor JR, Kennedy LA, Lehner T. HLA antigens in recurrent oral ulceration. Arch Dermatol. 1977 Dec;113(12):1717–1719. [PubMed]
  • Gallina G, Cumbo V, Messina P, Caruso C. HLA-A, B, C, DR, MT, and MB antigens in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol. 1985 Apr;59(4):364–370. [PubMed]
  • Chajek-Shaul T, Pisanty S, Knobler H, Matzner Y, Glick M, Ron N, Rosenman E, Brautbar C. HLA-B51 may serve as an immunogenetic marker for a subgroup of patients with Behçet's syndrome. Am J Med. 1987 Oct;83(4):666–672. [PubMed]
  • Gazit E, Brautbar C, Mizrachi Y, Cohen R, Yehoshua H, Zamir R. HLA polymorphism in Israel. 7. The Babylonian Jews. Tissue Antigens. 1978 Mar;11(3):226–229. [PubMed]
  • Amar A, Zohar M, Tiwari J, Brautbar C. HLA and schizophrenia in Israel. Isr J Med Sci. 1988 Jan;24(1):28–31. [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...