Logo of annrheumdAnnals of the Rheumatic DiseasesVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. 1991 May; 50(5): 331–336.
PMCID: PMC1004423

Small intestinal mucosal protection mechanisms and their importance in rheumatology.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.2M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Gravallese EM, Kantrowitz FG. Arthritic manifestations of inflammatory bowel disease. Am J Gastroenterol. 1988 Jul;83(7):703–709. [PubMed]
  • Wands JR, LaMont JT, Mann E, Isselbacher KJ. Arthritis associated with intestinal-bypass procedure for morbid obesity. Complement activation and characterization of circulating cryoproteins. N Engl J Med. 1976 Jan 15;294(3):121–124. [PubMed]
  • Mielants H, Veys EM, Cuvelier C, de Vos M. Ileocolonoscopic findings in seronegative spondylarthropathies. Br J Rheumatol. 1988;27 (Suppl 2):95–105. [PubMed]
  • Ebringer A. The relationship between Klebsiella infection and ankylosing spondylitis. Baillieres Clin Rheumatol. 1989 Aug;3(2):321–338. [PubMed]
  • Katz KD, Hollander D. Intestinal mucosal permeability and rheumatological diseases. Baillieres Clin Rheumatol. 1989 Aug;3(2):271–284. [PubMed]
  • Bjarnason I, Williams P, So A, Zanelli GD, Levi AJ, Gumpel JM, Peters TJ, Ansell B. Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs. Lancet. 1984 Nov 24;2(8413):1171–1174. [PubMed]
  • Bjarnason I, Zanelli G, Smith T, Prouse P, Williams P, Smethurst P, Delacey G, Gumpel MJ, Levi AJ. Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans. Gastroenterology. 1987 Sep;93(3):480–489. [PubMed]
  • Brandtzaeg P, Baklien K. Immunohistochemical studies of the formation and epithelial transport of immunoglobulins in normal and diseased human intestinal mucosa. Scand J Gastroenterol Suppl. 1976;36:1–45. [PubMed]
  • Brandtzaeg P, Korsrud FR. Significance of different J chain profiles in human tissues: generation of IgA and IgM with binding site for secretory component is related to the J chain expressing capacity of the total local immunocyte population, including IgG and IgD producing cells, and depends on the clinical state of the tissue. Clin Exp Immunol. 1984 Dec;58(3):709–718. [PMC free article] [PubMed]
  • Mestecky J, McGhee JR. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol. 1987;40:153–245. [PubMed]
  • Brandtzaeg P. The secretory immune system of lactating human mammary glands compared with other exocrine organs. Ann N Y Acad Sci. 1983 Jun 30;409:353–382. [PubMed]
  • Freter R. Mechanism of Action of Intestinal Antibody in Experimental Cholera II. Antibody-Mediated Antibacterial Reaction at the Mucosal Surface. Infect Immun. 1970 Nov;2(5):556–562. [PMC free article] [PubMed]
  • Colten HR, Bienenstock J. Lack of C3 activation through classical or alternate pathways by human secretory IgA anti blood group A antibody. Adv Exp Med Biol. 1974;45(0):305–308. [PubMed]
  • Bjarnason I, Peters J. Helping the mucosa make sense of macromolecules. Gut. 1987 Sep;28(9):1057–1061. [PMC free article] [PubMed]
  • Mestecky J, McGhee JR, Arnold RR, Michalek SM, Prince SJ, Babb JL. Selective induction of an immune response in human external secretions by ingestion of bacterial antigen. J Clin Invest. 1978 Mar;61(3):731–737. [PMC free article] [PubMed]
  • Elson CO. Induction and control of the gastrointestinal immune system. Scand J Gastroenterol Suppl. 1985;114:1–15. [PubMed]
  • Mestecky J, McGhee JR, Michalek SM, Arnold RR, Crago SS, Babb JL. Concept of the local and common mucosal immune response. Adv Exp Med Biol. 1978;107:185–192. [PubMed]
  • Jertborn M, Svennerholm AM, Holmgren J. Saliva, breast milk, and serum antibody responses as indirect measures of intestinal immunity after oral cholera vaccination or natural disease. J Clin Microbiol. 1986 Aug;24(2):203–209. [PMC free article] [PubMed]
  • Sartor RB. Importance of intestinal mucosal immunity and luminal bacterial cell wall polymers in the aetiology of inflammatory joint diseases. Baillieres Clin Rheumatol. 1989 Aug;3(2):223–245. [PubMed]
  • Park H, Schumacher HR, Zeiger AR, Rosenbaum JT. Antibodies to peptidoglycan in patients with spondylarthritis: a clue to disease aetiology? Ann Rheum Dis. 1984 Oct;43(5):725–728. [PMC free article] [PubMed]
  • Brandtzaeg P, Baklien K. Immunoglobulin-producing cells in the intestine in health and disease. Clin Gastroenterol. 1976 May;5(2):251–269. [PubMed]
  • Stodell MA, Butler RC, Zemelman VA, Henry K, Brewerton DA. Increased numbers of IgG-containing cells in rectal lamina propria of patients with ankylosing spondylitis. Ann Rheum Dis. 1984 Apr;43(2):172–176. [PMC free article] [PubMed]
  • Segal AW, Isenberg DA, Hajirousou V, Tolfree S, Clark J, Snaith ML. Preliminary evidence for gut involvement in the pathogenesis of rheumatoid arthritis? Br J Rheumatol. 1986 May;25(2):162–166. [PubMed]
  • Rooney PJ, Jenkins RT, Smith KM, Coates G. 111Indium-labelled polymorphonuclear leucocyte scans in rheumatoid arthritis--an important clinical cause of false positive results. Br J Rheumatol. 1986 May;25(2):167–170. [PubMed]
  • Bjarnason I, Hopkinson N, Zanelli G, Prouse P, Smethurst P, Gumpel JM, Levi AJ. Treatment of non-steroidal anti-inflammatory drug induced enteropathy. Gut. 1990 Jul;31(7):777–780. [PMC free article] [PubMed]
  • Franssen MJ, van de Putte LB, Gribnau FW. IgA serum levels and disease activity in ankylosing spondylitis: a prospective study. Ann Rheum Dis. 1985 Nov;44(11):766–771. [PMC free article] [PubMed]
  • Sanders KM, Hertzman A, Escobar MR, Littman BH. Correlation of immunoglobulin and C reactive protein levels in ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis. 1987 Apr;46(4):273–276. [PMC free article] [PubMed]
  • Ebringer RW, Cawdell DR, Cowling P, Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis. 1978 Apr;37(2):146–151. [PMC free article] [PubMed]
  • Trull AK, Ebringer R, Panayi GS, Colthorpe D, James DC, Ebringer A. IgA antibodies to Klebsiella pneumoniae in ankylosing spondylitis. Scand J Rheumatol. 1983;12(3):249–253. [PubMed]
  • Trull A, Ebringer A, Panayi G, Ebringer R, James DC. HLA-B27 and the immune response to enterobacterial antigens in ankylosing spondylitis. Clin Exp Immunol. 1984 Jan;55(1):74–80. [PMC free article] [PubMed]
  • Pease CT, Fordham JN, Stubbs MM, Archer JR. IgA antibodies to gram-negative bacteria in the serum and saliva of patients with ankylosing spondylitis. Scand J Rheumatol. 1987;16(3):199–203. [PubMed]
  • Cooper R, Fraser SM, Sturrock RD, Gemmell CG. Raised titres of anti-klebsiella IgA in ankylosing spondylitis, rheumatoid arthritis, and inflammatory bowel disease. Br Med J (Clin Res Ed) 1988 May 21;296(6634):1432–1434. [PMC free article] [PubMed]
  • Westedt ML, Daha MR, Baldwin WM, 3rd, Stijnen T, Cats A. Serum immune complexes containing IgA appear to predict erosive arthritis in a longitudinal study in rheumatoid arthritis. Ann Rheum Dis. 1986 Oct;45(10):809–815. [PMC free article] [PubMed]
  • Inman RD, Johnston ME, Klein MH. Analysis of serum and synovial fluid IgA in Reiter's syndrome and reactive arthritis. Clin Immunol Immunopathol. 1987 May;43(2):195–203. [PubMed]
  • Granfors K, Toivanen A. IgA-anti-yersinia antibodies in yersinia triggered reactive arthritis. Ann Rheum Dis. 1986 Jul;45(7):561–565. [PMC free article] [PubMed]
  • Eastmond CJ. Gram-negative bacteria and B27 disease. Br J Rheumatol. 1983 Nov;22(4 Suppl 2):67–74. [PubMed]
  • Smith MD, Gibson RA, Brooks PM. Abnormal bowel permeability in ankylosing spondylitis and rheumatoid arthritis. J Rheumatol. 1985 Apr;12(2):299–305. [PubMed]
  • Ukabam SO, Clamp JR, Cooper BT. Abnormal small intestinal permeability to sugars in patients with Crohn's disease of the terminal ileum and colon. Digestion. 1983;27(2):70–74. [PubMed]
  • Hawkey CJ. Non-steroidal anti-inflammatory drugs and peptic ulcers. BMJ. 1990 Feb 3;300(6720):278–284. [PMC free article] [PubMed]
  • Kent TH, Cardelli RM, Stamler FW. Small intestinal ulcers and intestinal flora in rats given indomethacin. Am J Pathol. 1969 Feb;54(2):237–249. [PMC free article] [PubMed]
  • Madhok R, MacKenzie JA, Lee FD, Bruckner FE, Terry TR, Sturrock RD. Small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs for rheumatoid arthritis. Q J Med. 1986 Jan;58(225):53–58. [PubMed]
  • Langman MJ, Morgan L, Worrall A. Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and haemorrhage. Br Med J (Clin Res Ed) 1985 Feb 2;290(6465):347–349. [PMC free article] [PubMed]
  • Bjarnason I, Price AB, Zanelli G, Smethurst P, Burke M, Gumpel JM, Levi AJ. Clinicopathological features of nonsteroidal antiinflammatory drug-induced small intestinal strictures. Gastroenterology. 1988 Apr;94(4):1070–1074. [PubMed]
  • Kaufmann HJ, Taubin HL. Nonsteroidal anti-inflammatory drugs activate quiescent inflammatory bowel disease. Ann Intern Med. 1987 Oct;107(4):513–516. [PubMed]
  • Marks JS, Gleeson MH. Steatorrhoea complicating therapy with mefenamic acid. Br Med J. 1975 Nov 22;4(5994):442–442. [PMC free article] [PubMed]
  • Satoh H, Guth PH, Grossman MI. Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics. Gastroenterology. 1983 Mar;84(3):483–489. [PubMed]
  • Robert A. Cytoprotection by prostaglandins. Gastroenterology. 1979 Oct;77(4 Pt 1):761–767. [PubMed]
  • Bjarnason I, Williams P, Smethurst P, Peters TJ, Levi AJ. Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine. Gut. 1986 Nov;27(11):1292–1297. [PMC free article] [PubMed]
  • Bjarnason I, Smethurst P, Fenn CG, Lee CE, Menzies IS, Levi AJ. Misoprostol reduces indomethacin-induced changes in human small intestinal permeability. Dig Dis Sci. 1989 Mar;34(3):407–411. [PubMed]
  • Krugliak P, Hollander D, Le K, Ma T, Dadufalza VD, Katz KD. Regulation of polyethylene glycol 400 intestinal permeability by endogenous and exogenous prostanoids. Influence of non-steroidal anti-inflammatory drugs. Gut. 1990 Apr;31(4):417–421. [PMC free article] [PubMed]
  • Scott DL. Clinical measurements in rheumatology. Br J Rheumatol. 1987 Apr;26(2):81–83. [PubMed]
  • Saverymuttu SH, Peters AM, Lavender JP, Hodgson HJ, Chadwick VS. 111Indium autologous leucocytes in inflammatory bowel disease. Gut. 1983 Apr;24(4):293–299. [PMC free article] [PubMed]
  • Bjarnason I, Zanelli G, Prouse P, Smethurst P, Smith T, Levi S, Gumpel MJ, Levi AJ. Blood and protein loss via small-intestinal inflammation induced by non-steroidal anti-inflammatory drugs. Lancet. 1987 Sep 26;2(8561):711–714. [PubMed]
  • Bjarnason I, Peters TJ. Intestinal permeability, non-steroidal anti-inflammatory drug enteropathy and inflammatory bowel disease: an overview. Gut. 1989 Nov;30(Spec No):22–28. [PMC free article] [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group


Save items

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...