• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of annrheumdAnnals of the Rheumatic DiseasesVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. Oct 1990; 49(10): 753–756.
PMCID: PMC1004225

Smoking, lung function, and rheumatoid factors.

Abstract

Positive rheumatoid factor (RF) reactions commonly precede the onset of clinically manifest rheumatoid arthritis (RA). Thus if items associated with RF reactions were traced at the community level this might provide clues to the cause of RA. The relations between smoking and lung functions and the occurrence of RA and RFs in a population sample representative of the adult Finnish population were studied. Rheumatoid factor testing was performed for 7124 subjects (89% of the sample) by the sensitised sheep cell agglutination test. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were measured with spirometry. 'False positive' RF reactions occurred twice as often in current smokers and ex-smokers than in those who had never smoked. The prevalence of high titres was fourfold greater among current smokers than among those who had never smoked. These associations were statistically significant and independent of age, FVC, and FEV1 in both sexes. The women with airflow limitation (FEV1/FVC less than 70%) had a significantly increased occurrence of RFs which was independent of their smoking history, but no such relationship was found in men. The results suggest an impact of smoking on RF production; a follow up study may show whether the raised RF titers in smokers will be reflected as an increased incidence of RA.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (690K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Hunninghake GW, Fauci AS. Pulmonary involvement in the collagen vascular diseases. Am Rev Respir Dis. 1979 Mar;119(3):471–503. [PubMed]
  • TOMASI TB, Jr, FUDENBERG HH, FINBY N. Possible relationship of rheumatoid factors and pulmonary disease. Am J Med. 1962 Aug;33:243–248. [PubMed]
  • SIEVERS K, AHO K, HURRI L, PERTTALA Y. STUDIES OF RHEUMATOID PULMONARY DISEASE. A COMPARISON OF ROENTGENOLOGICAL FINDINGS AMONG PATIENTS WITH HIGH RHEUMATOID FACTOR TITERS AND WITH COMPLETELY NEGATIVE REACTIONS. Acta Tuberc Pneumol Scand. 1964;45:21–34. [PubMed]
  • Bégin R, Massé S, Cantin A, Ménard HA, Bureau MA. Airway disease in a subset of nonsmoking rheumatoid patients. Characterization of the disease and evidence for an autoimmune pathogenesis. Am J Med. 1982 May;72(5):743–750. [PubMed]
  • Hakala M, Ruuska P, Hämeenkorpi R, Tiilikainen A, Ilonen J, Mäkitalo R. Diffuse interstitial lung disease in rheumatoid arthritis. Views on immunological and HLA findings. Scand J Rheumatol. 1986;15(4):368–376. [PubMed]
  • Frank ST, Weg JG, Harkleroad LE, Fitch RF. Pulmonary dysfunction in rheumatoid disease. Chest. 1973 Jan;63(1):27–34. [PubMed]
  • Laitinen O, Nissilä M, Salorinne Y, Aalto P. Pulmonary involvement in patients with rheumatoid arthritis. Scand J Respir Dis. 1975;56(6):297–304. [PubMed]
  • Geddes DM, Corrin B, Brewerton DA, Davies RJ, Turner-Warwick M. Progressive airway obliteration in adults and its association with rheumatoid disease. Q J Med. 1977 Oct;46(184):427–444. [PubMed]
  • Hyland RH, Gordon DA, Broder I, Davies GM, Russell ML, Hutcheon MA, Reid GD, Cox DW, Corey PN, Mintz S. A systematic controlled study of pulmonary abnormalities in rheumatoid arthritis. J Rheumatol. 1983 Jun;10(3):395–405. [PubMed]
  • Sassoon CS, McAlpine SW, Tashkin DP, Baydur A, Quismorio FP, Mongan ES. Small airways function in nonsmokers with rheumatoid arthritis. Arthritis Rheum. 1984 Nov;27(11):1218–1226. [PubMed]
  • Davidson C, Brooks AG, Bacon PA. Lung function in rheumatoid arthritis. A clinic survey. Ann Rheum Dis. 1974 Jul;33(4):293–297. [PMC free article] [PubMed]
  • WARD R. Pleural effusion and rheumatoid disease. Lancet. 1961 Dec 16;2(7216):1336–1338. [PubMed]
  • Jurik AG, Graudal H. Pleurisy in rheumatoid arthritis. Scand J Rheumatol. 1983;12(2):75–80. [PubMed]
  • Aho K, Palosuo T, Raunio V, Puska P, Aromaa A, Salonen JT. When does rheumatoid disease start? Arthritis Rheum. 1985 May;28(5):485–489. [PubMed]
  • Aho K, Palosuo T, Niemelä N, Takala J. Rheumatoid factor seroconversions in relation to clinical rheumatoid arthritis. Ann Clin Res. 1985;17(1):15–18. [PubMed]
  • Walker DJ, Pound JD, Griffiths ID, Powell RJ. Rheumatoid factor tests in the diagnosis and prediction of rheumatoid arthritis. Ann Rheum Dis. 1986 Aug;45(8):684–690. [PMC free article] [PubMed]
  • del Puente A, Knowler WC, Pettitt DJ, Bennett PH. The incidence of rheumatoid arthritis is predicted by rheumatoid factor titer in a longitudinal population study. Arthritis Rheum. 1988 Oct;31(10):1239–1244. [PubMed]
  • Aho K, Heliövaara M, Sievers K, Maatela J, Isomäki H. Clinical arthritis associated with positive radiological and serological findings in Finnish adults. Rheumatol Int. 1989;9(1):7–11. [PubMed]
  • WILLIAMS RC, Jr, KUNKEL HG. Rheumatoid factor, complement, and conglutinin aberrations in patients with subacute bacterial endocarditis. J Clin Invest. 1962 Mar;41:666–675. [PMC free article] [PubMed]
  • AHO K, KONTTINEN A, RAJASALMI M, WAGER O. Transient appearance of the rheumatoid factor in connection with prophylactic vaccinations. Acta Pathol Microbiol Scand. 1962;56:478–479. [PubMed]
  • Palosuo T, Husman T, Koistinen J, Aho K. C-reactive protein in population samples. Acta Med Scand. 1986;220(2):175–179. [PubMed]
  • Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med. 1978 Apr 20;298(16):869–871. [PubMed]
  • Nepom GT, Byers P, Seyfried C, Healey LA, Wilske KR, Stage D, Nepom BS. HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes. Arthritis Rheum. 1989 Jan;32(1):15–21. [PubMed]
  • Engleman EG, Sponzilli EE, Batey ME, Ramcharan S, McDevitt HO. Mixed lymphocyte reaction in healthy women with rheumatoid factor. Lack of association with HLA-Dw4. Arthritis Rheum. 1978 Jul-Aug;21(6):690–693. [PubMed]
  • de Jongh BM, van Romunde LK, Valkenburg HA, de Lange GG, van Rood JJ. Epidemiological study of HLA and GM in rheumatoid arthritis and related symptoms in an open Dutch population. Ann Rheum Dis. 1984 Aug;43(4):613–619. [PMC free article] [PubMed]
  • Gran JT, Husby G, Thorsby E. The prevalence of HLA-DR4 and HLA-DR3 in healthy persons with rheumatoid factor. Scand J Rheumatol. 1985;14(1):79–82. [PubMed]
  • Lawrence JS, Locke GB, Ball J. Rheumatoid serum factor in populations in the U.K. I. Lung disease and rheumatoid serum factor. Clin Exp Immunol. 1971 May;8(5):723–729. [PMC free article] [PubMed]
  • Mathews JD, Whittingham S, Hooper BM, Mackay IR, Stenhouse NS. Association of autoantibodies with smoking, cardiovascular morbidity, and death in the Busselton population. Lancet. 1973 Oct 6;2(7832):754–758. [PubMed]
  • Vessey MP, Villard-Mackintosh L, Yeates D. Oral contraceptives, cigarette smoking and other factors in relation to arthritis. Contraception. 1987 May;35(5):457–464. [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...