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Ann Rheum Dis. 1990 Jan; 49(1): 37–39.
PMCID: PMC1003961

Comparison of labial and sublingual salivary gland biopsies in the diagnosis of Sjögren's syndrome.


This study was designed to compare labial and sublingual salivary gland biopsies in the diagnosis of Sjögren's syndrome (SS). Fourteen labial and 29 sublingual specimens were considered positive. There was a better correlation between infiltration of the ductal structure and the focus score in the sublingual salivary gland biopsy than in the labial salivary gland biopsy. Use of sublingual salivary gland biopsy as an additional diagnostic tool in SS is therefore suggested.

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Selected References

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  • Youinou P, Pennec Y. Immunopathological features of primary Sjögren's syndrome. Clin Exp Rheumatol. 1987 Apr-Jun;5(2):173–184. [PubMed]
  • Moutsopoulos HM, Chused TM, Mann DL, Klippel JH, Fauci AS, Frank MM, Lawley TJ, Hamburger MI. Sjögren's syndrome (Sicca syndrome): current issues. Ann Intern Med. 1980 Feb;92(2 Pt 1):212–226. [PubMed]
  • Mackie IA, Seal DV. The questionably dry eye. Br J Ophthalmol. 1981 Jan;65(1):2–9. [PMC free article] [PubMed]
  • Daniels TE, Silverman S, Jr, Michalski JP, Greenspan JS, Sylvester RA, Talal N. The oral component of Sjögren's syndrome. Oral Surg Oral Med Oral Pathol. 1975 Jun;39(6):875–885. [PubMed]
  • Cifarelli PS, Bennett MJ, Zaino EC. Sjogren's syndrome. A case report with an additional diagnostic aid. Arch Intern Med. 1966 Mar;117(3):429–431. [PubMed]
  • WATERHOUSE JP. FOCAL ADENITIS IN SALIVARY AND LACRIMAL GLANDS. Proc R Soc Med. 1963 Oct;56:911–918. [PMC free article] [PubMed]
  • Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol. 1968 Sep;21(5):656–660. [PMC free article] [PubMed]
  • Greenspan JS, Daniels TE, Talal N, Sylvester RA. The histopathology of Sjögren's syndrome in labial salivary gland biopsies. Oral Surg Oral Med Oral Pathol. 1974 Feb;37(2):217–229. [PubMed]
  • Tarpley TM, Jr, Anderson LG, White CL. Minor salivary gland involvement in Sjögren's syndrome. Oral Surg Oral Med Oral Pathol. 1974 Jan;37(1):64–74. [PubMed]
  • Daniels TE. Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. Arthritis Rheum. 1984 Feb;27(2):147–156. [PubMed]
  • Vitali C, Tavoni A, Simi U, Marchetti G, Vigorito P, d'Ascanio A, Neri R, Cristofani R, Bombardieri S. Parotid sialography and minor salivary gland biopsy in the diagnosis of Sjögren's syndrome. A comparative study of 84 patients. J Rheumatol. 1988 Feb;15(2):262–267. [PubMed]
  • Bertram U, Hjorting-Hansen E. Punch-biopsy of minor salivary glands in the diagnosis of Sjögren's syndrome. Scand J Dent Res. 1970;78(3):295–300. [PubMed]
  • Chisholm DM, Waterhouse JP, Mason DK. Lymphocytic sialadenitis in the major and minor glands: a correlation in postmortem subjects. J Clin Pathol. 1970 Nov;23(8):690–694. [PMC free article] [PubMed]
  • Marx RE, Hartman KS, Rethman KV. A prospective study comparing incisional labial to incisional parotid biopsies in the detection and confirmation of sarcoidosis, Sjögren's disease, sialosis and lymphoma. J Rheumatol. 1988 Apr;15(4):621–629. [PubMed]

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