Logo of annrheumdAnnals of the Rheumatic DiseasesVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. Jan 1988; 47(1): 65–68.
PMCID: PMC1003446

Low free testosterone levels in rheumatoid arthritis.


The androgen status of 25 male patients with rheumatoid arthritis (RA) was assessed and compared with that of age matched controls with osteoarthritis (OA). Significantly reduced levels of serum free testosterone were found in the RA group. Within that group free testosterone was unrelated to all indices of disease activity measured, though it was strongly related to latex positivity. These results support the hypothesis that male sex hormones may have a protective role in RA, though prospective studies would be necessary to determine whether the relation was one of cause or effect.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (522K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Lahita RG. Sex steroids and the rheumatic diseases. Arthritis Rheum. 1985 Feb;28(2):121–126. [PubMed]
  • Inman RD. Immunologic sex differences and the female predominance in systemic lupus erythematosus. Arthritis Rheum. 1978 Sep-Oct;21(7):849–852. [PubMed]
  • Linos A, Worthington JW, O'Fallon WM, Kurland LT. The epidemiology of rheumatoid arthritis in Rochester, Minnesota: a study of incidence, prevalence, and mortality. Am J Epidemiol. 1980 Jan;111(1):87–98. [PubMed]
  • Davidson JM, Chen JJ, Crapo L, Gray GD, Greenleaf WJ, Catania JA. Hormonal changes and sexual function in aging men. J Clin Endocrinol Metab. 1983 Jul;57(1):71–77. [PubMed]
  • Gordon D, Beastall GH, Thomson JA, Sturrock RD. Androgenic status and sexual function in males with rheumatoid arthritis and ankylosing spondylitis. Q J Med. 1986 Jul;60(231):671–679. [PubMed]
  • Masi AT, Josipović DB, Jefferson WE. Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion. Semin Arthritis Rheum. 1984 Aug;14(1):1–23. [PubMed]
  • Fehér KG, Fehér T. Plasma dehydroepiandrosterone, dehydroepiandrosterone sulphate and androsterone sulphate levels and their interaction with plasma proteins in rheumatoid arthritis. Exp Clin Endocrinol. 1984 Oct;84(2):197–202. [PubMed]
  • Dougados M, Nahoul K, Benhamou L, Amor B. Androgen plasma levels in female rheumatoid arthritis patients. Arthritis Rheum. 1983 Jul;26(7):935–936. [PubMed]
  • Cutolo M, Balleari E, Giusti M, Monachesi M, Accardo S. Sex hormone status in women suffering from rheumatoid arthritis. J Rheumatol. 1986 Dec;13(6):1019–1023. [PubMed]
  • Blalock JE, Smith EM, Meyer WJ., 3rd The pituitary-adrenocortical axis and the immune system. Clin Endocrinol Metab. 1985 Nov;14(4):1021–1038. [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • MedGen
    Related information in MedGen
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...