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Ann Rheum Dis. 1987 Nov; 46(11): 830–836.
PMCID: PMC1003401

Iliac crest trabecular bone mass and structure in patients with non-steroid treated rheumatoid arthritis.


Iliac crest trabecular bone volume and structure have been studied in bone biopsy specimens from 48 patients with classical or definite rheumatoid arthritis, none of whom had received steroids. Results were compared with those obtained from healthy controls matched for age and sex. The mean trabecular bone volume in female patients aged 34-50 years was significantly lower than in controls (p less than 0.01); in male patients aged 34-50 years values were also lower than those in controls (mean (SD) 17.8 (3.2) v 22.4 (5.6)% total medullary volume), though this difference was not statistically significant. Values in older patients were similar to those of controls. The mean trabecular plate thickness was significantly lower in female patients in all three age groups when compared with the controls (p less than 0.005, 0.05, and 0.005). Similar but non-significant changes were seen in male patients. The mean trabecular plate density, an index of trabecular number, and the mean trabecular plate separation showed no age related change in either male or female patients, in contrast with the female control group, in whom the mean trabecular plate density decreased and separation increased with age. These results suggest that non-steroid treated rheumatoid arthritis is associated with premature bone loss, the structural basis of which is trabecular thinning.

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  • Duncan H, Frost HM, Villanueva AR, Sigler JW. The osteoporosis of rheumatoid arthritis. Arthritis Rheum. 1965 Oct;8(5):943–954. [PubMed]
  • Saville PD, Kharmosh O. Osteoporosis of rheumatoid arthritis: influence of age, sex and corticosteroids. Arthritis Rheum. 1967 Oct;10(5):423–430. [PubMed]
  • Bjelle AO, Nilsson BE. Osteoporosis in rheumatoid arthritis. Calcif Tissue Res. 1970;5(4):327–332. [PubMed]
  • Mueller MN, Jurist JM. Skeletal status in rheumatoid arthritis. A preliminary report. Arthritis Rheum. 1973 Jan-Feb;16(1):66–70. [PubMed]
  • Als OS, Christiansen C, Hellesen C. Prevalence of decreased bone mass in rheumatoid arthritis. Relation to anti-inflammatory treatment. Clin Rheumatol. 1984 Jun;3(2):201–208. [PubMed]
  • Reid DM, Kennedy NS, Smith MA, Tothill P, Nuki G. Total body calcium in rheumatoid arthritis: effects of disease activity and corticosteroid treatment. Br Med J (Clin Res Ed) 1982 Jul 31;285(6338):330–332. [PMC free article] [PubMed]
  • Hancock DA, Asiedu-Offei S, Atkinson PJ, Reed GW, Wright V. Femoral bone mass in patients with rheumatoid arthritis and osteoarthrosis. Rheumatol Rehabil. 1978 May;17(2):65–71. [PubMed]
  • Hooyman JR, Melton LJ, 3rd, Nelson AM, O'Fallon WM, Riggs BL. Fractures after rheumatoid arthritis. A population-based study. Arthritis Rheum. 1984 Dec;27(12):1353–1361. [PubMed]
  • Verstraeten A, Dequeker J. Vertebral and peripheral bone mineral content and fracture incidence in postmenopausal patients with rheumatoid arthritis: effect of low dose corticosteroids. Ann Rheum Dis. 1986 Oct;45(10):852–857. [PMC free article] [PubMed]
  • Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest. 1983 Oct;72(4):1396–1409. [PMC free article] [PubMed]
  • BENNETT GA, COBB S, JACOX R, JESSAR RA, ROPES MW. Proposed diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1956 Dec;7(4):121–124. [PubMed]
  • Vedi S, Compston JE, Webb A, Tighe JR. Histomorphometric analysis of bone biopsies from the iliac crest of normal British subjects. Metab Bone Dis Relat Res. 1982;4(4):231–236. [PubMed]
  • Ng KC, Revell PA, Beer M, Boucher BJ, Cohen RD, Currey HL. Incidence of metabolic bone disease in rheumatoid arthritis and osteoarthritis. Ann Rheum Dis. 1984 Jun;43(3):370–377. [PMC free article] [PubMed]
  • Wordsworth BP, Vipond S, Woods CG, Mowat AG. Metabolic bone disease among in-patients with rheumatoid arthritis. Br J Rheumatol. 1984 Nov;23(4):251–257. [PubMed]
  • Wakamatsu E, Sissons HA. The cancellous bone of the iliac crest. Calcif Tissue Res. 1969;4(2):147–161. [PubMed]
  • Aaron JE, Makins NB, Sagreiya K. The microanatomy of trabecular bone loss in normal aging men and women. Clin Orthop Relat Res. 1987 Feb;(215):260–271. [PubMed]
  • Virtama P, Helelä T, Kalliomäki JL. Osteoporosis in rheumatoid arthritis. A follow-up study. Acta Rheumatol Scand. 1968;14(4):276–284. [PubMed]
  • Heaney RP, Walch JJ, Steffes P, Skillman TG. Periarticular bone remodeling in rheumatoid arthritis. Calcif Tissue Res. 1968;(Suppl):33–33b. [PubMed]
  • Sambrook PN, Ansell BM, Foster S, Gumpel JM, Hesp R, Reeve J, Zanelli JM. Bone turnover in early rheumatoid arthritis. 1. Biochemical and kinetic indexes. Ann Rheum Dis. 1985 Sep;44(9):575–579. [PMC free article] [PubMed]
  • Rosenspire KC, Kennedy AC, Steinbach J, Blau M, Green FA. Investigation of the metabolic acitivity of bone in rheumatoid arthritis. J Rheumatol. 1980 Jul-Aug;7(4):469–473. [PubMed]

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