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Ann Rheum Dis. May 1986; 45(5): 373–378.
PMCID: PMC1001894

Long term progression of joint damage in rheumatoid arthritis.

Abstract

Joint damage in rheumatoid arthritis is assessed radiologically. Previous studies have not examined in detail its long term progression. We evaluated the overall changes of peripheral joint damage radiologically in 50 rheumatoid patients followed up at one rheumatology centre for 10 years. All peripheral joints were scored in 12 groups with Larsen's standard films at 0 and 10 years. In 48 cases the total scored deteriorated (mean increase 13% maximum damage). There was no different pattern of progression in any of the patients, though seropositive patients had more initial damage and a greater rate of progress. The wrist and small joints of the feet were most affected initially. During the 10 years most progression occurred in the wrist, knee, and metacarpophalangeal joints. Progression occurred in both initially normal and abnormal joints. By 10 years only 16.5% joint groups showed no damage. Complete destruction was most common in the wrist, knee, and small joints of the feet. Damage to the hands and wrists have a god indication of overall changes at 0 and 10 years and also the increase in damage (correlation coefficients were from r = 0.74 to r = 0.85). These results show that specific joints are involved in different stages of the disease. Some joints are frequently involved and some less often. The hands and the wrists give a reasonable picture of the overall progression of damage.

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Selected References

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  • Jacoby RK, Jayson MI, Cosh JA. Onset, early stages, and prognosis of rheumatoid arthritis: a clinical study of 100 patients with 11-year follow-up. Br Med J. 1973 Apr 14;2(5858):96–100. [PMC free article] [PubMed]
  • Brook A, Fleming A, Corbett M. Relationship of radiological change to clinical outcome in rheumatoid arthritis. Ann Rheum Dis. 1977 Jun;36(3):274–275. [PMC free article] [PubMed]
  • Young A, Corbett M, Brook A. The clinical assessment of joint inflammatory activity in rheumatoid arthritis related to radiological progression. Rheumatol Rehabil. 1980 Feb;19(1):14–19. [PubMed]
  • Scott DL, Grindulis KA, Struthers GR, Coulton BL, Popert AJ, Bacon PA. Progression of radiological changes in rheumatoid arthritis. Ann Rheum Dis. 1984 Feb;43(1):8–17. [PMC free article] [PubMed]
  • Scott DL, Dawes PT, Fowler PD, Grindulis KA, Shadforth M, Bacon PA. Anti-rheumatic drugs and joint damage in rheumatoid arthritis. Q J Med. 1985 Jan;54(213):49–59. [PubMed]
  • Luukkainen R, Kaarela K, Isomäki H, Martio J, Kiviniemi P, Räsänen J, Sarna S. The prediction of radiological destruction during the early stage of rheumatoid arthritis. Clin Exp Rheumatol. 1983 Oct-Dec;1(4):295–298. [PubMed]
  • Ingeman-Nielsen M, Halskov O, Hansen TM, Halberg P, Stage P, Lorenzen I. Clinical synovitis and radiological lesions in rheumatoid arthritis. A prospective study of 25 patients during treatment with remission-inducing drugs. Scand J Rheumatol. 1983;12(3):237–240. [PubMed]
  • de Carvalho A, Graudal H. Radiographic progression of rheumatoid arthritis related to some clinical and laboratory parameters. Acta Radiol Diagn (Stockh) 1980;21(4):551–555. [PubMed]
  • Amos RS, Constable TJ, Crockson RA, Crockson AP, McConkey B. Rheumatoid arthritis: relation of serum C-reactive protein and erythrocyte sedimentation rates to radiographic changes. Br Med J. 1977 Jan 22;1(6055):195–197. [PMC free article] [PubMed]
  • Larsen A, Dale K, Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh) 1977 Jul;18(4):481–491. [PubMed]
  • Scott DL, Coulton BL, Chapman JH, Bacon PA, Popert AJ. The long-term effects of treating rheumatoid arthritis. J R Coll Physicians Lond. 1983 Jan;17(1):79–85. [PubMed]
  • Grindulis KA, Scott DL, Struthers GR. The assessment of radiological changes in the hands and wrists in rheumatoid arthritis. Rheumatol Int. 1983;3(1):39–42. [PubMed]
  • Swann DA, Bloch KJ, Swindell D, Shore E. The lubricating activity of human synovial fluids. Arthritis Rheum. 1984 May;27(5):552–556. [PubMed]
  • Owsianik WD, Kundi A, Whitehead JN, Kraag GR, Goldsmith C. Radiological articular involvement in the dominant hand in rheumatoid arthritis. Ann Rheum Dis. 1980 Oct;39(5):508–510. [PMC free article] [PubMed]
  • Larsen A. Radiological grading of rheumatoid arthritis. An interobserver study. Scand J Rheumatol. 1973;2(3):136–138. [PubMed]
  • Larsen A, Edgren J, Harju E, Laasonen L, Reitamo T. Interobserver variation in the evaluation of radiologic changes of rheumatoid arthritis. Scand J Rheumatol. 1979;8(2):109–112. [PubMed]
  • de Carvalho A, Graudal H, Jørgensen B. Radiologic evaluation of the progression of rheumatoid arthritis. Acta Radiol Diagn (Stockh) 1980;21(1):115–121. [PubMed]
  • de Carvalho A. Discriminative power of Larsen's grading system for assessing the course of rheumatoid arthritis. Acta Radiol Diagn (Stockh) 1981;22(1):77–80. [PubMed]
  • Luukkainen R, Kajander A, Isomäki H. Effect of gold on progression of erosions in rheumatoid arthritis. Better results with early treatment. Scand J Rheumatol. 1977;6(3):189–192. [PubMed]
  • Luukkainen R, Isomäki H, Kajander A. Effect of gold treatment on the progression of erosions in RA patients. Scand J Rheumatol. 1977;6(2):123–127. [PubMed]
  • Gofton JP. Problems associated with the measurement of radiologic progression of disease in rheumatoid arthritis. J Rheumatol. 1983 Apr;10(2):177–179. [PubMed]
  • Trentham DE, Masi AT. Carpo:metacarpal ratio. A new quantitative measure of radiologic progression of wrist involvement in rheumatioid arthritis. Arthritis Rheum. 1976 Sep-Oct;19(5):939–944. [PubMed]
  • Campion G, Dieppe P, Watt I. Heberden's nodes in osteoarthritis and rheumatoid arthritis. Br Med J (Clin Res Ed) 1983 Nov 19;287(6404):1512–1512. [PMC free article] [PubMed]
  • Iannuzzi L, Dawson N, Zein N, Kushner I. Does drug therapy slow radiographic deterioration in rheumatoid arthritis? N Engl J Med. 1983 Oct 27;309(17):1023–1028. [PubMed]
  • Luukkainen R, Isomäki H, Kajander A. Prognostic value of the type of onset of rheumatoid arthritis. Ann Rheum Dis. 1983 Jun;42(3):274–275. [PMC free article] [PubMed]
  • Burns TM, Calin A. The hand radiograph as a diagnostic discriminant between seropositive and seronegative 'rheumatoid arthritis': a controlled study. Ann Rheum Dis. 1983 Dec;42(6):605–612. [PMC free article] [PubMed]

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