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Logo of annrheumdAnnals of the Rheumatic DiseasesCurrent TOCInstructions for authors
Ann Rheum Dis. Dec 1983; 42(6): 677–679.
PMCID: PMC1001328

Leukotriene B4, a mediator of inflammation present in synovial fluid in rheumatoid arthritis.


Leukotriene B4 (LTB4), generated from arachidonic acid following lipoxygenase activity by a variety of inflammatory leucocytes, has been shown to be present in synovial fluid from patients with active rheumatoid arthritis. It does not persist as such, being converted to less active metabolites. The role of LTB4 as one of the natural mediators of inflammation is discussed.

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Selected References

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  • Bray MA, Ford-Hutchinson AW, Smith MJ. Leukotriene B4: an inflammatory mediator in vivo. Prostaglandins. 1981 Aug;22(2):213–222. [PubMed]
  • Powell WS. Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. Prostaglandins. 1980 Nov;20(5):947–957. [PubMed]
  • Borgeat P, Samuelsson B. Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187. Proc Natl Acad Sci U S A. 1979 May;76(5):2148–2152. [PMC free article] [PubMed]
  • Cunningham FM, Shipley ME, Smith MJ. Aggregation of rat polymorphonuclear leucocytes in vitro. J Pharm Pharmacol. 1980 May;32(5):377–380. [PubMed]
  • Ford-Hutchinson AW, Bray MA, Doig MV, Shipley ME, Smith MJ. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature. 1980 Jul 17;286(5770):264–265. [PubMed]
  • Hansson G, Lindgren JA, Dahlén SE, Hedqvist P, Samuelsson B. Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes. FEBS Lett. 1981 Jul 20;130(1):107–112. [PubMed]
  • Davidson EM, Rae SA, Smith MJ. Leukotriene B4 in synovial fluid. J Pharm Pharmacol. 1982 Jun;34(6):410–410. [PubMed]
  • Klickstein LB, Shapleigh C, Goetzl EJ. Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis. J Clin Invest. 1980 Nov;66(5):1166–1170. [PMC free article] [PubMed]

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