Logo of annrheumdAnnals of the Rheumatic DiseasesVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
Ann Rheum Dis. Feb 1984; 43(1): 76–79.
PMCID: PMC1001227

Mast cells at sites of cartilage erosion in the rheumatoid joint.


Cartilage-pannus junctions of the rheumatoid lesion have been examined by histochemical and ultrastructural techniques in an attempt to identify the cells responsible for cartilage degradation. Mast cells have been identified at sites of cartilage erosion in 3 specimens of rheumatoid joint. It is known that mast cells participate in immunological reactions, produce the vasoactive and proteinase-modulating agents histamine and heparin as well as their own degradative proteinases. The close association of mast cells with sites of cartilage erosion suggests they may play an important role in the pathophysiology of joint destruction in rheumatoid arthritis.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.3M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • CASTOR CW. The microscopic structure of normal human synovial tissue. Arthritis Rheum. 1960 Apr;3:140–151. [PubMed]
  • Wynne-Roberts CR, Anderson CH, Turano AM, Baron M. Light- and electron-microscopic findings of juvenile rheumatoid arthritis synovium: comparison with normal juvenile synovium. Semin Arthritis Rheum. 1978 May;7(4):287–302. [PubMed]
  • SMYTH CJ, GUM OB. Mast cells in connective tissue diseases. Arthritis Rheum. 1958 Apr;1(2):178–180. [PubMed]
  • Austen KF. Homeostasis of effector systems which can also be recruited for immunologic reactions. J Immunol. 1978 Sep;121(3):793–805. [PubMed]
  • Austen KF. Biologic implications of the structural and functional characteristics of the chemical mediators of immediate-type hypersensitivity. Harvey Lect. 1979;73:93–161. [PubMed]
  • Lewis RA, Austen KF. Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds. Nature. 1981 Sep 10;293(5828):103–108. [PubMed]
  • Yam LT, Li CY, Crosby WH. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. [PubMed]
  • Mohr W, Wessinghage D. The relationship between polymorphonuclear granulocytes and cartilage destruction in rheumatoid arthritis. Z Rheumatol. 1978 Mar-Apr;37(3-4):81–86. [PubMed]
  • Mohr W, Menninger H. Polymorphonuclear granulocytes at the pannus-cartilage junction in rheumatoid arthritis. Arthritis Rheum. 1980 Dec;23(12):1413–1414. [PubMed]
  • Li CY, Yam LT, Crosby WH. Histochemical characterization of cellular and structural elements of the human spleen. J Histochem Cytochem. 1972 Dec;20(12):1049–1058. [PubMed]
  • Kobayashi I, Ziff M. Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum. 1975 Sep-Oct;18(5):475–483. [PubMed]
  • Gryfe A, Sanders PM, Gardner DL. The mast cell in early rat adjuvant arthritis. Ann Rheum Dis. 1971 Jan;30(1):24–30. [PMC free article] [PubMed]
  • Taylor S, Folkman J. Protamine is an inhibitor of angiogenesis. Nature. 1982 May 27;297(5864):307–312. [PubMed]
  • Sakamoto S, Sakamoto M, Goldhaber P, Glimcher MJ. Studies on the interaction between heparin and mouse bone collagenase. Biochim Biophys Acta. 1975 Mar 14;385(1):41–50. [PubMed]
  • Lenaers-Claeys G, Vaes G. Collagenase, procollagenase and bone resorption. Effects of heparin, parathyroid hormone and calcitonin. Biochim Biophys Acta. 1979 May 16;584(3):375–388. [PubMed]
  • Woolley DE, Crossley MJ, Evanson JM. Collagenase at sites of cartilage erosion in the rheumatoid joint. Arthritis Rheum. 1977 Jul-Aug;20(6):1231–1239. [PubMed]
  • Menninger H, Putzier R, Mohr W, Wessinghage D, Tillmann K. Granulocyte elastase at the site of cartilage erosion by rheumatoid synovial tissue. Z Rheumatol. 1980 May-Jun;39(5-6):145–156. [PubMed]
  • Schwartz LB, Austen KF. Enzymes of the mast cell granule. J Invest Dermatol. 1980 May;74(5):349–353. [PubMed]
  • Permin H, Skov PS, Norn S, Geisler A, Klysner R, Andersen V, Wiik A, Manthorpe R, Nielsen H, Petersen J. Possible role of histamine in rheumatoid arthritis. Treatment with cimetidine and mepyramine. Allergy. 1981 Aug;36(6):435–436. [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...